未登录 Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis 鉴定JNJ-61803534，一种用于治疗银屑病的RORγt反向激动剂 Kinzel, Olaf; Goldberg, Steven D.; Cummings, Maxwell D.; Gege, Christian; Steeneck, Christoph; Xue, Xiaohua; Albers, Michael; Schluter, Thomas; Kleymann, Gerald; Scott, Brian; Sepassi, Kia; Schoetens, Freddy; Venkatesan, Hariharan; Tanis, Virginia M.; Coe, Kevin; Sales, Zachary S.; Spurlino, John; Milligan, Cynthia; Fourie, Anne M.; Edwards, James P.; Hoffmann, Thomas 分享 收藏
Towards a vacuum birefringence experiment at the Helmholtz International Beamline for Extreme Fields (Letter of Intent of the BIREF@HIBEF Collaboration) 关于在Helmholtz International Beamline for Extreme Fields进行真空双折射实验的提议（BIREF@HIBEF合作团队的意向书） Ahmadiniaz, N.; Baehtz, C.; Benediktovitch, A.; Boemer, C.; Bocklage, L.; Cowan, T. E.; Edwards, J.; Evans, S.; Vinas, S. Franchino; Gies, H.; Goede, S.; Goers, J.; Grenzer, J.; Hernandez Acosta, U.; Heinzl, T.; Hilz, P.; Hippler, W.; Huang, L. G.; Humphries, O.; Karbstein, F.; Khademi, P.; King, B.; Kluge, T.; Kohlfuerst, C.; Krebs, D.; Laso-Garcia, A.; Loetzsch, R.; Macleod, A. J.; Marx-Glowna, B.; Mosman, E. A.; Nakatsutsumi, M.; Paulus, G. G.; Rahul, S. V.; Randolph, L.; Roehlsberger, R.; Rohringer, N.; Saevert, A.; Sadashivaiah, S.; Sauerbrey, R.; Schlenviogt, H. -p.; Schmidt, S. M.; Schramm, U.; Schuetzhold, R.; Schwinkendorf, J. -p.; Seipt, D.; Smid, M.; Stoehlker, T.; Toncian, T.; Valialshchikov, M.; Wipf, A.; Zastrau, U.; Zepf, M. 分享 收藏
Toward Dose Prediction at Point of Design Van Rompaey, Dries; Chaudhuri, Siladitya Ray; Ahmad, Mazen; Cisar, Justin; van den Bergh, An; Ash, Jeremy; Wu, Zhe; Bryan, Marian C.; Edwards, James P.; Desjarlais, Renee; Wegner, Jorg Kurt; Ceulemans, Hugo; Mitra, Kaushik; Polidori, David 分享 收藏
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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML DeRatt, Lindsey G.; Zhang, Zhuming; Pietsch, Christine; Cisar, Justin S.; Zhang, Xiaochun; Wang, Weixue; Tanner, Alexandra; Matico, Rosalie; Shaffer, Paul; Jacoby, Edgar; Kazmi, Faraz; Shukla, Neetu; Bush, Tammy L.; Patrick, Aaron; Philippar, Ulrike; Attar, Ricardo; Edwards, James P.; Kuduk, Scott D. 分享 收藏
Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors DeRatt, Lindsey G.; Pietsch, E. Christine; Cisar, Justin S.; Jacoby, Edgar; Kazmi, Faraz; Matico, Rosalie; Shaffer, Paul; Tanner, Alexandra; Wang, Weixue; Attar, Ricardo; Edwards, James P.; Kuduk, Scott D. 分享 收藏
Identification of small-molecule protein-protein interaction inhibitors for NKG2D Thompson, Aaron A.; Harbut, Michael B.; Kung, Pei-Pei; Karpowich, Nathan K.; Branson, Jeffrey D.; Grant, Joanna C.; Hagan, Deborah; Pascual, Heather A.; Bai, Guoyun; Zavareh, Reza Beheshti; Coate, Heather R.; Collins, Bernard C.; Cote, Marjorie; Gelin, Christine F.; Damm-Ganamet, Kelly L.; Gholami, Hadi; Huff, Adam R.; Limon, Luis; Lum, Kevin J.; Mak, Puiying A.; Nakafuku, Kohki M.; V. Price, Edmund; Shih, Amy Y.; Tootoonchi, Mandana; Vellore, Nadeem A.; Wang, Jocelyn; Wei, Na; Ziff, Jeannie; Berger, Scott B.; Edwards, James P.; Gardet, Agnes; Sun, Siquan; Towne, Jennifer E.; Venable, Jennifer D.; Shi, Zhicai; Venkatesan, Hariharan; Rives, Marie-Laure; Sharma, Sujata; Shireman, Brock T.; Allen, Samantha J. 分享 收藏
Discovery of OICR12694: A Novel, Potent, Selective, and Orally Biovailable BCL6 BTB Inhibitor Mamai, Ahmed; Chau, Anh M.; Wilson, Brian J.; Watson, Iain D.; Joseph, Babu B.; Subramanian, Pandiaraju R.; Morshed, Monzur M.; Morin, Justin A.; Prakesh, Michael A.; Lu, Tianbao; Connolly, Pete; Kuntz, Douglas A.; Pomroy, Neil C.; Poda, Gennady; Nguyen, Kong; Marcellus, Richard; Strathdee, Graig; Theriault, Brigitte; Subramaniam, Ratheesh; Mohammed, Mohammed; Abibi, Ayome; Chan, Manuel; Winston, Jeffrey; Kiyota, Taira; Undzys, Elijus; Aman, Ahmed; Austin, Nigel; Du Jardin, Marc; Packman, Kathryn; Phillippar, Ulrike; Attar, Riccardo; Edwards, James; O'Meara, Jeff; Uehling, David E.; Al-awar, Rima; Prive, Gilbert G.; Isaac, Methvin B. 分享 收藏
Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase Tichenor, Mark S.; Wiener, John J. M.; Rao, Navin L.; Bacani, Genesis M.; Wei, Jianmei; Deckhut, Charlotte Pooley; Barbay, J. Kent; Kreutter, Kevin D.; Chang, Leon; Clancy, Kathleen W.; Murrey, Heather E.; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J.; Wu, Jiejun; Rui, Haopeng; Sepassi, Kia; Gaudiano, Marcello; Bekkers, Mariette; Cornelissen, Ivo; Packman, Kathryn; Seierstad, Mark; Xiouras, Christos; Bembenek, Scott D.; Alexander, Richard; Milligan, Cynthia; Balasubramanian, Sriram; Lebsack, Alec D.; Venable, Jennifer D.; Philippar, Ulrike; Edwards, James P.; Hirst, Gavin 分享 收藏
N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia Cisar, Justin S.; Pietsch, Christine; DeRatt, Lindsey G.; Jacoby, Edgar; Kazmi, Faraz; Keohane, Colleen; Legenski, Katie; Matico, Rosalie; Shaffer, Paul; Simonnet, Yvan; Tanner, Alexandra; Wang, Chao -Yuan; Wang, Weixue; Attar, Ricardo; Edwards, James P.; Kuduk, Scott D. 分享 收藏
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Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer Zhang, Zhuming; Ghosh, Avijit; Connolly, Peter J.; King, Peter; Wilde, Thomas; Wang, Jianyao; Dong, Yawei; Li, Xueliang; Liao, Daohong; Chen, Hao; Tian, Gaochao; Suarez, Javier; Bonnette, William G.; Pande, Vineet; Diloreto, Karen A.; Shi, Yifan; Patel, Shefali; Pietrak, Beth; Szewczuk, Lawrence; Sensenhauser, Carlo; Dallas, Shannon; Edwards, James P.; Bachman, Kurtis E.; Evans, David C. 分享 收藏
Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL Fu, Liqiang; Zhang, Jing; Shen, Bin; Kong, Linglong; Liu, Yingtao; Tu, Wangyang; Wang, Wenqian; Cai, Xin; Wang, Xiaotao; Cheng, Na; Xia, Mingxuan; Zhou, Tianyuan; Liu, Qian; Xu, Yanping; Yang, Jennifer; Gavine, Paul; Philippar, Ulrike; Attar, Ricardo; Edwards, James P.; Venable, Jennifer D.; Dai, Xuedong 分享 收藏
Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity Tichenor, Mark S.; Wiener, John J. M.; Rao, Navin L.; Deckhut, Charlotte Pooley; Barbay, J. Kent; Kreutter, Kevin D.; Bacani, Genesis M.; Wei, Jianmei; Chang, Leon; Murrey, Heather E.; Wang, Weixue; Ahn, Kay; Huber, Michael; Rex, Elizabeth; Coe, Kevin J.; Wu, JieJun; Seierstad, Mark; Bembenek, Scott D.; Leonard, Kristi A.; Lebsack, Alec D.; Venable, Jennifer D.; Edwards, James P. 分享 收藏
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation 通过IRAK4激酶抑制和蛋白质降解评估IRAK4在ABC DLBCL中的功能 Zhang, Jing; Fu, Liqiang; Shen, Bin; Liu, Yingtao; Wang, Wenqian; Cai, Xin; Kong, Linglong; Yan, Yilin; Meng, Ryan; Zhang, Zhuming; Chen, Ying-Nan P.; Liu, Qian; Wan, Zhao-Kui; Zhou, Tianyuan; Wang, Xiaotao; Gavine, Paul; Del Rosario, Amanda; Ahn, Kay; Philippar, Ulrike; Attar, Ricardo; Yang, Jennifer; Xu, Yanping; Edwards, James P.; Dai, Xuedong 分享 收藏
Discovery of JNJ-67856633: A novel, first-in-class MALT1 protease inhibitor for the treatment of B cell lymphomas Philippar, Ulrike; Lu, Tianbao; Vloemans, Nele; Bekkers, Mariette; Van Nuffel, Luc; Gaudiano, Marcello; Wnuk-Lipinska, Katarzyna; Van der Leede, Bas-jan; Amssoms, Katie; Kimpe, Kristof; Medaer, Bart; Greway, Tony; Abraham, Yann; Cummings, Max; Trella, Emanuele; Vanhoof, Greet; Sun, Weimei; Thuring, Jan Willem; Connolly, Peter; Linders, Jan; Rui, Haopeng; Balasubramanian, Sriram; Johnson, Amy; Gerecitano, John; Goldberg, Jenna; Edwards, James P.; Elsayed, Yusri; Smit, Jennifer; Bussolari, Jaqueline; Attar, Ricardo 分享 收藏
JNJ-'6196: A next generation STING agonist with potent preclinical activity by the IV route Chan, Szeman Ruby; Bignan, Gilles; Pierson, Emily; Mahady, Sally; Ta, Hayley; Schepens, Wim; Thuring, Jan Willem; Lim, Heng Keang; Otieno, Monicah; Wilde, Thomas; Singer, Monica; Bogdan, Nancy; Patel, Shefali; Luistro, Leo; Campion, Liam; Smith, Melissa; Wiley, Diana; Packman, Kathryn; Allegrezza, Michael; Morgan, Caitlin; Sendecki, Jocelyn; Van Aller, Glenn; Krosky, Daniel; Connolly, Peter; Edwards, James; Staquet, Kim; Emanuel, Stuart L. 分享 收藏
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