未登录ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression
Natarajan, Siva Kumar; Lum, Joanna; Skeans, James Haggerty; Nenwani, Minal; Eyunni, Sanjana; Mota, Mateus; Bayliss, Jill M.; Deogharkar, Akash; Hamanishi, Erin Taya; Pun, Matthew; Sweha, Stefan R.; Hoffman, Simon; Young, Eleanor; Zhang, Qiuyang; Mehta, Rijul; Animasahun, Olamide; Narayanan, Pranav; Sunil, Sushanth; Parolia, Abhijit; Sajjakulnukit, Peter; Panwalkar, Pooja; Doherty, Robert; Clausen, Madison; Dang, Derek; Hawes, Debra; Yang, Fusheng; Santi, Mariarita; Judkins, Alexander R.; Wilson, Yelena; Vigil, Thomas; Franson, Andrea; Mortensen, Richard M.; Ozawa, Tatsuya; Griesinger, Andrea; Holland, Eric C.; Foreman, Nicholas K.; Michealraj, Kulandaimanuvel Antony; Agnihotri, Sameer; Taylor, Michael; Gilbertson, Richard J.; Koschmann, Carl; Chinnaiyan, Arul M.; Lyssiotis, Costas A.; Nagrath, Deepak; Venneti, Sriram .png)
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收藏ZFTA-RELA ependymomas produce macrophage-associated itaconate as an oncometabolite to epigenetically sustain pathogenic fusion expressionZFTA-RELA室管膜瘤产生与巨噬细胞相关的衣康酸作为表观遗传学上维持致病融合表达的一种肿瘤代谢物。Natarajan, Siva Kumar; Lum, Joanna; Haggerty-Skeans, James; Nenwani, Minal; Eyunni, Sanjana; Mota, Mateus; Bayliss, Jill; Deogharkar, Akash; Hamanishi, Erin; Hoffman, Simon; Young, Eleanor; Zhang, Qiuyang; Mehta, Rijul; Parolia, Abhijit; Sajjakulnukit, Peter; Doherty, Robert; Koschmann, Carl; Chinnaiyan, Arul; Lyssiotis, Costas; Nagrath, Deepak; Venneti, Sriram 分享 收藏 分享 收藏 NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesisParolia, Abhijit; Eyunni, Sanjana; Verma, Brijesh Kumar; Young, Eleanor; Liu, Yihan; Liu, Lianchao; George, James; Aras, Shweta; Das, Chandan Kanta; Mannan, Rahul; Rasool, Reyaz Ur; Mitchell-Velasquez, Erick; Mahapatra, Somnath; Luo, Jie; Carson, Sandra E.; Xiao, Lanbo; Gajjala, Prathibha R.; Venkatesh, Sharan; Jaber, Mustapha; Wang, Xiaoju; He, Tongchen; Qiao, Yuanyuan; Pang, Matthew; Zhang, Yuping; Tien, Jean Ching-Yi; Louw, Micheala; Alhusayan, Mohammed; Cao, Xuhong; Su, Fengyun; Tavana, Omid; Hou, Caiyun; Wang, Zhen; Ding, Ke; Chinnaiyan, Arul M.; Asangani, Irfan A. 分享 收藏 FOXA1 alterations distinctively drive prostate tumorigenesis or therapy resistance in miceEyunni, Sanjana; Parolia, Abhijit; Young, Eleanor; George, James Matthew; Mannan, Rahul; Carson, Sandra E.; Zhang, Yuping; Tien, Jean; Jaber, Mustapha; Luo, Jie; Pang, Matthew; Mehra, Rohit; Cao, Xuhong; Su, Fengyun; Wang, Rui; Cieslik, Marcin; Lee, Dong Kee; Xu, Jianming; Chinnaiyan, Arul M. 分享 收藏 A long-read sequencing strategy with overlapping linkers on adjacent fragments (OLAF-Seq) for targeted resequencing and enrichmentUppuluri, Lahari; Shi, Christina Huan; Varapula, Dharma; Young, Eleanor; Ehrlich, Rachel L.; Wang, Yilin; Piazza, Danielle; Mell, Joshua Chang; Yip, Kevin Y.; Xiao, Ming 分享 收藏 The Pathfinder plasmid toolkit for genetically engineering newly isolated bacteria enables the study of Drosophila-colonizing Orbaceae (vol 3, 119 , 2023)Elston, Katherine M.; Phillips, Laila E.; Leonard, Sean P.; Young, Eleanor; Holley, Jo-anne C.; Ahsanullah, Tasneem; McReynolds, Braydin; Moran, Nancy A.; Barrick, Jeffrey E. 分享 收藏 AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesisEyunni, Sanjana; Parolia, Abhijit; Young, Eleanor; George, James; Jaber, Mustapha; Xiao, Lanbo; Su, Fengyun; Wang, Rui; Cao, Xuhong; Chinnaiyan, Arul 分享 收藏 NSD2 is a requisite and targetable subunit of the AR/FOXA1 neo-enhanceosome complex in prostate cancer cellsParolia, Abhijit; Verma, Brijesh K.; Eyunni, Sanjana; Aras, Sweta; Carson, Sandra E.; Young, Eleanor; Das, Chandan K.; George, James M.; Rasool, Reyaz ur; Gajjala, Prathibha; Alhusayan, Mohammed; Mitchell-Velasquez, Erick; Xiao, Lanbo; Luo, Jie; Jaber, Mustapha; Cao, Xuhong; Su, Fengyun; Wang, Rui; Liu, Lianchao; Wang, Zhen; Ding, Ke; Chinnaiyan, Arul M.; Asangani, Irfan 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Towards a reference genome that captures global genetic diversity迈向捕获全球遗传多样性的参考基因组Wong, Karen H. Y.; Ma, Walfred; Wei, Chun-Yu; Yeh, Erh-Chan; Lin, Wan-Jia; Wang, Elin H. F.; Su, Jen-Ping; Hsieh, Feng-Jen; Kao, Hsiao-Jung; Chen, Hsiao-Huei; Chow, Stephen K.; Young, Eleanor; Chu, Catherine; Poon, Annie; Yang, Chi-Fan; Lin, Dar-Shong; Hu, Yu-Feng; Wu, Jer-Yuarn; Lee, Ni-Chung; Hwu, Wuh-Liang; Boffelli, Dario; Martin, David; Xiao, Ming; Kwok, Pui-Yan 分享 收藏 Optical mapping of the 22q11.2DS region reveals complex repeat structures and preferred locations for non-allelic homologous recombination (NAHR)Pastor, Steven; Tran, Oanh; Jin, Andrea; Carrado, Danielle; Silva, Benjamin A.; Uppuluri, Lahari; Abid, Heba Z.; Young, Eleanor; Crowley, T. Blaine; Bailey, Alice G.; McGinn, Daniel E.; McDonald-McGinn, Donna M.; Zackai, Elaine H.; Xie, Michael; Taylor, Deanne; Morrow, Bernice E.; Xiao, Ming; Emanuel, Beverly S. 分享 收藏 分享 收藏 分享 收藏 Genome maps across 26 human populations reveal population-specific patterns of structural variationLevy-Sakin, Michal; Pastor, Steven; Mostovoy, Yulia; Li, Le; Leung, Alden K. Y.; McCaffrey, Jennifer; Young, Eleanor; Lam, Ernest T.; Hastie, Alex R.; Wong, Karen H. Y.; Chung, Claire Y. L.; Ma, Walfred; Sibert, Justin; Rajagopalan, Ramakrishnan; Jin, Nana; Chow, Eugene Y. C.; Chu, Catherine; Poon, Annie; Lin, Chin; Naguib, Ahmed; Wang, Wei-Ping; Cao, Han; Chan, Ting-Fung; Yip, Kevin Y.; Xiao, Ming; Kwok, Pui-Yan 分享 收藏 
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