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Filip Van Petegem

University of British Columbia

44H指数
313论文数
6.1K被引数
收录论文 128
发表时间
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The kinase homology and dimerization domains in retinal membrane guanylyl cyclase 1 form the binding interface for the calcium sensor GCAP1视网膜膜鸟苷酸环化酶1中的激酶同源性和二聚化结构域形成钙离子传感器GCAP1的结合界面
errJournal of Biological Chemistry
IF3.9
err2026-09-25
err0
errOAAI
errIgor V. Peshenko; Lyuqi Tan; Jai Mahto; Filip Van Petegem; Robert S. Molday; Alexander M. Dizhoor
err分享
err收藏
A neurocutaneous NaV1.8 channelopathy underlies a genetic subtype of primary idiopathic hyperhidrosis一种神经皮肤NaV1.8通道病构成了原发性特发性多汗症的一种遗传亚型
errScience Advances
IF12.5
err2026-07-17
err0
errOAAI
errSuguru Yamauchi; Jolien Vander Cruyssen; Michele Cervellera; Elizabeth Wohler; Jolien De Waele; Maxime Lammens; Corinne Boehm; Nara L Sobreira; Carley Blevins; Kaitlyn Ecoff; Yuping Mei; Margaux Theys; Ife Shoyombo; Maria Shishikura; Hongrui Yi; Kristen Rodgers; Beverly Lee; Hamza Khan; Andrei Gurau; Wasay Nizam; Shivani Shirodkar; Christine Kim; Joshua Choi; Daniel Coleman; Brooke Dorman; Takumi Iwasawa; Jin U Kang; Yves Heremans; Hajime Orita; Tetsu Fukunaga; Filip Van Petegem; Stephen B Baylin; Andreas S Barth; Tae Hwan Chung; Peter C Rowe; Glenn Treisman; Jinny Ha; Ruslan I Dmitriev; David Valle; Frank Bosmans; Malcolm V Brock
err分享
err收藏
Structural insights into insect-selective sodium channel toxins drive AI-enhanced biopesticide design对昆虫选择性钠通道毒素的结构见解推动了AI增强的生物农药设计
errNature Communications
IF15.7
err2026-03-06
err0
errOAAI
errHeng Jiang; Ruibo Gao; Huiqin Xu; Cheng Wang; Shuyue Ma; Yishu Gong; Lianyun Lin; Lina Yang; Xiang Li; Ye Liu; Rongcai Lu; Jun-An Ma; Jinbo Xu; Ke Dong; Filip Van Petegem; Zheng Liu; Shaoying Wu; Zhiguang Yuchi
err分享
err收藏
An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channelHCN2通道中环核苷酸的熵驱动和负协同结合需要亚基间路径
errCommunications Biology
IF5.1
err2026-02-04
err0
errOAAI
errFlavio Costa; Leo C. T. Ng; Sarah S. Chow; Filip Van Petegem; Eric A. Accili
err分享
err收藏
Identification of novel potentially causative RYR1 variants in individuals with Malignant Hyperthermia Susceptibility在恶性高热易感个体中发现新型潜在的致病性RYR1变异
errNeuromuscular Disorders
IF2.8
err2025-11-25
err0
PREAI
errDaniela Rossi; Carlotta Pranzo; Sara Roccabianca; Lucia Galli; Alfredo Orrico; Giovanna Sorbello; Vincenzo Tegazzin; Pasquale D’Onofrio; Armando Fucci; Salvatore Quarta; Stefano Perni; Egidio Maria Rubino; Matteo Serano; Gianna Berti; Diego Lopergolo; Alessandro Malandrini; Filip Van Petegem; Vincenzo Sorrentino
err分享
err收藏
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets冷冻电子显微镜揭示了Statins三聚体对Ryanodine受体的顺序结合与激活
errNature Communications
IF15.7
err2025-11-20
err0
errOAAI
errSteven Molinarolo; Carmen R. Valdivia; Héctor H. Valdivia; Filip Van Petegem
err分享
err收藏
Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor developmentryanodine受体晶体结构揭示了丹曲洛林和azumolene的相互作用，指导抑制剂开发
errNature Communications
IF15.7
err2025-11-18
err0
errOAAI
errHadiatullah Hadiatullah; Lianyun Lin; Zhiyan Wang; Rajamanikandan Sundarraj; Qing Wang; Xinru Lai; Nagomi Kurebayashi; Takuya Kobayashi; Toshiko Yamazawa; Yu Seby Chen; Wenlan Wang; Hongxia Zhao; Yiqing Yin; Takashi Murayama; Filip Van Petegem; Zhiguang Yuchi
err分享
err收藏
Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat strokeRYR1在Ser2902位点的磷酸化可降低骨骼肌中的Ca2+泄漏，并降低对恶性高热和热射病的易感性。
errScience Signaling
IF6.6
err2025-10-07
err0
PREAI
errRachel Sue Zhen Yee; Chang Seok Lee; Ting Chang; Sung Yun Jung; Omar Yousif; Courtney Cavazos; John Colyer; Filip Van Petegem; George G. Rodney; Susan L. Hamilton
err分享
err收藏
A physiologically-relevant intermediate state structure of a voltage-gated potassium channel电压门控钾通道的生理相关中间状态结构
errNature Communications
IF15.7
err2025-10-03
err0
errOAAI
errEfthimios Kyriakis; Daniel Sastre; Jodene Eldstrom; Agnese Roscioni; Sophia Russo; Fariba Ataei; Ying Dou; Magnus Chan; Steven Molinarolo; Luca Maragliano; Filip Van Petegem; David Fedida
err分享
err收藏
Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics靶向L型钙通道的新型肽类疗法通过降低线粒体能量代谢来预防肥厚型心肌病
errjacc basic to translational science
IF0
err2025-08-27
err0
errOAAI
errTeagan S. Er; Daniel Reinke; Alice J. Francis; Tanya M. Solomon; Helena M. Viola; Henrietta Cserne Szappanos; Caitlyn M. Richworth; Catherine Jenkins; Juan E. Camacho Londoño; Padmapriya Ponnuswamy; Ciaran McFarlane; Filip Van Petegem; Livia C. Hool
err分享
err收藏
Training/Practice: Contemporary Issues in Cardiology Practice Beyond NT-ProBNP: Circulating Protein Biomarkers for Atrial Fibrillation in Heart Failure and Cardiomyopathy
errCANADIAN JOURNAL OF CARDIOLOGY
IF5.3
err2025-01-01
err0
PREAI
errDababneh, Saif; Van Petegem, Filip; Laksman, Zachary
err分享
err收藏
Crystallographic, kinetic, and calorimetric investigation of PKA interactions with L-type calcium channels and Rad GTPase
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2025-01-01
err0
errOAAI
errYoo, Randy; Haji-Ghassemi, Omid; Bader, Marvin; Xu, Jiaming; Mcfarlane, Ciaran; Van Petegem, Filip
err分享
err收藏
The design of novel therapeutics that target the L-type calcium channel to prevent hypertrophic cardiomyopathy靶向L型钙通道以预防肥厚型心肌病的新型治疗药物设计
errCIRCULATION
IF38.6
err2024-11-12
err0
PREAI
errHool, Livia; Er, Teagan; Reinke, Daniel; Francis, Alice; Solomon, Tanya; Viola, Helena; Szappanos, Henrietta Cserne; Richworth, Caitlyn; Vu, Khanh; Jenkins, Cathy; Londono, Juan Camacho; Ponnuswamy, Padmapriya; McFarlane, Ciaran; Van Petegem, Filip
err分享
err收藏
Propofol binds and inhibits skeletal muscle ryanodine receptor 1
errBRITISH JOURNAL OF ANAESTHESIA
IF9.2
err2024-11-01
err0
errOAAI
errJoseph, Thomas T.; Bu, Weiming; Haji-Ghassemi, Omid; Chen, Yu S.; Woll, Kellie; Allen, Paul D.; Brannigan, Grace; van Petegem, Filip; Eckenhoff, Roderic G.
err分享
err收藏
Elemental mapping in single-particle reconstructions by reconstructed electron energy-loss analysis
errNATURE METHODS
IF32.1
err2024-10-24
err1
errOAAI
errPfeil-Gardiner, Olivia; Rosa, Higor Vinicius Dias; Riedel, Dietmar; Chen, Yu Seby; Loerks, Dominique; Kuekelhan, Pirmin; Linck, Martin; Mueller, Heiko; Van Petegem, Filip; Murphy, Bonnie J.
err分享
err收藏
Cryo-EM structures of ryanodine receptors and diamide insecticides reveal the mechanisms of selectivity and resistance
errNATURE COMMUNICATIONS
IF15.7
err2024-10-20
err0
errOAAI
errLin, Lianyun; Wang, Changshi; Wang, Wenlan; Jiang, Heng; Murayama, Takashi; Kobayashi, Takuya; Hadiatullah, Hadiatullah; Chen, Yu Seby; Wu, Shunfan; Wang, Yiwen; Korza, Henryk; Gu, Yucheng; Zhang, Yan; Du, Jiamu; Van Petegem, Filip; Yuchi, Zhiguang
err分享
err收藏
Structural and functional characterization of the nucleotide-binding domains of ABCA4 and their role in Stargardt disease
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-09-01
err0
errOAAI
errScortecci, Jessica Fernandes; Garces, Fabian A.; Mahto, Jai K.; Molday, Laurie L.; Van Petegem, Filip; Molday, Robert S.
err分享
err收藏
The molecular basis of cereal mixed-linkage β-glucan utilization by the human gut bacterium Segatella copri
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-09-01
err1
errOAAI
errGolisch, Benedikt; Cordeiro, Rosa Lorizolla; Fraser, Alexander S. C.; Briggs, Jonathon; Stewart, William A.; Van Petegem, Filip; Brumer, Harry
err分享
err收藏
Individuals and Families Affected by RYR1-Related Diseases: The Patient/Caregiver Perspective
errJOURNAL OF NEUROMUSCULAR DISEASES
IF3.4
err2024-08-14
err0
errOAAI
errvan de Camp, Sanne A. J. H.; Stinissen, Lizan; Huseth, Andrew; Simon, Brentney; Ryan, Jennifer; Sarkozy, Anna; Van Petegem, Filip; Goldberg, Michael F.; Jungbluth, Heinz; Bohm, Johann; Oortwijn, Wija; Dirksen, Robert T.; Voermans, Nicol C.
err分享
err收藏
ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents
errJOURNAL OF GENERAL PHYSIOLOGY
IF2.9
err2024-07-23
err1
PREAI
errCollaco, Rita de Cassia; Van Petegem, Filip; Bosmans, Frank
err分享
err收藏

研究方向

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合作学者
合作期刊
S
Stephen B. Baylin
H 指数: 182 · 论文数: 1.3K
M
Michael J. Ackerman
H 指数: 154 · 论文数: 1.4K
A
Arthur A.M. Wilde
H 指数: 149 · 论文数: 1.2K
D
Donald M. Bers
H 指数: 127 · 论文数: 840
H
Henry Houlden
H 指数: 120 · 论文数: 1.5K
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