Lim, Shuhui; Boyer, Nicolas; Boo, Nicole; Huang, Chunhui; Venkatachalam, Gireedhar; Juang, Yu-Chi Angela; Garrigou, Michael; Kaan, Kristal; Duggal, Ruchia; Peh, Khong Ming; Sadruddin, Ahmad; Gopal, Pooja; Yuen, Tsz Ying; Ng, Simon; Kannan, Srinivasaraghavan; Brown, Christopher J.; Verma, Chandra; Orth, Peter; Peier, Andrea; Ge, Lan; Yu, Xiang; Bhatt, Bhavana; Chen, Feifei; Wang, Erjia; Li, Nianyu Jason; Gonzales, Raymond J.; Stoeck, Alexander; Henry, Brian; Sawyer, Tomi K.; Lane, David; Johannes, Charles W.; Biswas, Kaustav; Partridge, Anthony W.

Engineering Nav1.7 Inhibitory JzTx-V Peptides with a Potency and Basicity Profile Suitable for Antibody Conjugation To Enhance Pharmacokinetics

ACS CHEMICAL BIOLOGY

IF3.8

2019-03-1515

PREAI

Murray, Justin K.; Wu, Bin; Tegley, Christopher M.; Nixey, Thomas E.; Falsey, James R.; Herberich, Brad; Yin, Li; Sham, Kelvin; Long, Jason; Aral, Jennifer; Cheng, Yuan; Netirojjanakul, Chawita; Doherty, Liz; Glaust, Charles; Ikotun, Tayo; Li, Hongyan; Linh Tran; Soto, Marcus; Salimi-Moosavi, Hossein; Ligutti, Joseph; Amagasu, Shanti; Andrews, Kristin L.; Be, Xuhai; Lin, Min-Hwa Jasmine; Foti, Robert S.; Ilch, Christopher P.; Youngblood, Beth; Kornecook, Thomas J.; Karow, Margaret; Walker, Kenneth W.; Moyer, Bryan D.; Biswas, Kaustav; Miranda, Les P.

Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1

ACS CHEMICAL BIOLOGY

IF3.8

2018-12-0313

PREAI

Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-10-2222

OAAI

Discovery of TRPM8 Antagonist (S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-08-2745

PREAI

Engineering Antibody Reactivity for Efficient Derivatization to Generate Nav1.7 Inhibitory GpTx-1 Peptide Antibody Conjugates

ACS CHEMICAL BIOLOGY

IF3.8

2017-08-2828

PREAI

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2016-03-1050

PREAI

Unfolded Protein Response in Cancer: IRE1a Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2014-09-2995

OAAI

Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-08-0437

PREAI

Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-09-2627

PREAI

Potent nonpeptide antagonists of the bradykinin B1 receptor: Structure-activity relationship studies with novel diaminochroman carboxamides

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2007-04-0523

PREAI

Biswas, Kaustav; Li, Aiwen; Chen, Jian Jeffrey; D'Amico, Derin C.; Fotsch, Christopher; Han, Nianhe; Human, Jason; Liu, Qingyian; Norman, Mark H.; Riahi, Bobby; Yuan, Chester; Suzuki, Hideo; Mareska, David A.; Zhan, James; Clarke, David E.; Toro, Andras; Groneberg, Robert D.; Burgess, Laurence E.; Lester-Zeiner, Dianna; Biddlecome, Gloria; Manning, Barton H.; Arik, Leyla; Dong, Hong; Huang, Ming; Kamassah, Augustus; Loeloff, Richard; Sun, Hong; Hsieh, Feng-Yin; Kumar, Gondi; Ng, Gordon Y.; Hungate, Randall W.; Askew, Benny C.; Johnson, Eileen

Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2007-01-2323

PREAI

D'Amico, Derin C.; Aya, Toshi; Human, Jason; Fotsch, Christopher; Chen, Jian Jeffrey; Biswas, Kaustav; Riahi, Bobby; Norman, Mark H.; Willoughby, Christopher A.; Hungate, Randall; Reider, Paul J.; Biddlecome, Gloria; Lester-Zeiner, Dianna; Van Staden, Carlo; Johnson, Eileen; Kamassah, Augustus; Arik, Leyla; Wang, Judy; Viswanadhan, Vellarkad N.; Groneberg, Robert D.; Zhan, James; Suzuki, Hideo; Toro, Andras; Mareska, David A.; Clarke, David E.; Harvey, Darren M.; Burgess, Laurence E.; Laird, Ellen R.; Askew, Benny; Ng, Gordon

On the introduction of a trifluoromethyl substituent in the epothilone setting: Chemical issues related to ring forming olefin metathesis and earliest biological findings

ORGANIC LETTERS

IF5

2002-10-1754

PREAI

Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: Correlation of ring size with biological activity in the epothilone series

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2002-10-1047

PREAI

Kaustav Biswas

个人简介

教育背景

工作经历

荣誉奖项

研究方向