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D

Dominic P. Williams

glaxosmithkline
H指数:53
被引数:8,889

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Beyond NAMs versus animal models: Context of use as the governing framework for integrated nonclinical strategies in drug development

超越NAMs与动物模型：使用情境作为药物开发中综合非临床策略的指导框架

Regulatory Toxicology and Pharmacology
IF3.5
2026-09-010
PRE
Gaburro, Stefano; Berridge, Brian; Kelley, Nicholas W.; von Keutz, Eckhard; Ferrer, Marc; Roper, Clive; Fossler, Michael J.; Bajramovic, Jeffrey J.; Valentin, Jean-Pierre; McGovern, Timothy; Bourcier, Todd; Wange, Ronald L.; Snyder, Kevin; Phelan, Michael A.; Oliphant, Jessica H.; Leishman, Derek J.; Proctor, William R.; Maguire, Sean; Dama, Paola; Nag, Madhu; Williams, Dominic P.; Roth, Adrian; Kanda, Yasunari; Baran, Szczepan
Apoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery

凋亡标志物能够实现药物诱导性肝损伤的早期和快速筛查，以加速药物发现。

Communications Medicine
IF6.3
2025-12-240
OAAI
John Hellgren; Bhavik Chouhan; Aydar Uatay; Ramy Elgendy; Julia Lindgren; Naoko Toki; Alessandro Bonetti; Aditi Chaudhari; Kenneth Pryde; Patrik Andersson; Marie Kalm; Fredrik Karlsson; Johanna Sagemark; Dominic P. Williams; Jennifer Y. Tan; Bino John; John Gallon
Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017

行业视角下非临床方法用于肝毒性风险评估：来自2023年和2017年两项纵向调查的见解

Chemical Research in Toxicology
IF3.8
2025-10-130
PRE
Melanie Z. Sakatis; Leah M. Norona; Jamie E. Karmel; William R. Proctor; Fatou H. Sarr; Payal Rana; Doris Zane; Jessica Caverly Rae; Samantha C. Faber; Ravindra C. Kodihalli; Arie Regev; Debra Luffer-Atlas; Onyi Irrechukwu; David H. Alpers; Jonathan P. Jackson; Armando R. Irizarry Rovira; Dominic P. Williams
Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World

基于化学结构的毒性预测机器学习：现实世界成功的基石

CHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
2025-05-020
OA
Seal, Srijit; Mahale, Manas; Garcia-Ortegon, Miguel; Joshi, Chaitanya K.; Hosseini-Gerami, Layla; Beatson, Alex; Greenig, Matthew; Shekhar, Mrinal; Patra, Arijit; Weis, Caroline; Mehrjou, Arash; Badre, Adrien; Paisley, Brianna; Lowe, Rhiannon; Singh, Shantanu; Shah, Falgun; Johannesson, Bjarki; Williams, Dominic; Rouquie, David; Clevert, Djork-Arne; Schwab, Patrick; Richmond, Nicola; Nicolaou, Christos A.; Gonzalez, Raymond J.; Naven, Russell; Schramm, Carolin; Vidler, Lewis R.; Mansouri, Kamel; Walters, W. Patrick; Wilk, Deidre Dalmas; Spjuth, Ola; Carpenter, Anne E.; Bender, Andreas
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds
CHEMICO-BIOLOGICAL INTERACTIONS
IF5.4
2022-01-0119
OAAI
Brecklinghaus, Tim; Albrecht, Wiebke; Kappenberg, Franziska; Duda, Julia; Vartak, Nachiket; Edlund, Karolina; Marchan, Rosemarie; Ghallab, Ahmed; Cadenas, Cristina; Gunther, Georgia; Leist, Marcel; Zhang, Mian; Gardner, Iain; Reinders, Jorg; Russel, Frans G. M.; Foster, Alison J.; Williams, Dominic P.; Damle-Vartak, Amruta; Grandits, Melanie; Ecker, Gerhard; Kittana, Naim; Rahnenfuehrer, Jorg; Hengstler, Jan G.
In silico approaches in organ toxicity hazard assessment: Current status and future needs in predicting liver toxicity
COMPUTATIONAL TOXICOLOGY
IF2.9
2021-11-0122
OAAI
Bassan, Arianna; Alves, Vinicius M.; Amberg, Alexander; Anger, Lennart T.; Auerbach, Scott; Beilke, Lisa; Bender, Andreas; Cronin, Mark T. D.; Cross, Kevin P.; Hsieh, Jui-Hua; Greene, Nigel; Kemper, Raymond; Kim, Marlene T.; Mumtaz, Moiz; Noeske, Tobias; Pavan, Manuela; Pletz, Julia; Russo, Daniel P.; Sabnis, Yogesh; Schaefer, Markus; Szabo, David T.; Valentin, Jean-Pierre; Wichard, Joerg; Williams, Dominic; Woolley, David; Zwickl, Craig; Myatt, Glenn J.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

管理药物性肝损伤的挑战: 开发和部署临床前预测模型的路线图

NATURE REVIEWS DRUG DISCOVERY
IF101.8
2019-11-20156
OAAI
Weaver, Richard J.; Blomme, Eric A.; Chadwick, Amy E.; Copple, Ian M.; Gerets, Helga H. J.; Goldring, Christopher E.; Guillouzo, Andre; Hewitt, Philip G.; Ingelman-Sundberg, Magnus; Jensen, Klaus Gjervig; Juhila, Satu; Klingmuller, Ursula; Labbe, Gilles; Liguori, Michael J.; Lovatt, Cerys A.; Morgan, Paul; Naisbitt, Dean J.; Pieters, Raymond H. H.; Snoeys, Jan; van de Water, Bob; Williams, Dominic P.; Park, B. Kevin

研究方向

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S
Sophie Regan
H 指数:11论文数:50被引数:1,105
J
James L. Maggs
H 指数:44论文数:185被引数:5,745
D
Daniel J. Antoine
H 指数:49论文数:117被引数:9,506
K
Kevin Park
H 指数:19论文数:143被引数:1,401
C
Christopher E. Goldring
H 指数:53论文数:220被引数:1.2万
R
Rosalind E. Jenkins
H 指数:48论文数:170被引数:7,467
J
J. Gerry Kenna
H 指数:39论文数:124被引数:5,475
N
Neil R. Kitteringham
H 指数:55论文数:182被引数:1.0万
B
B. Kevin Park
H 指数:30论文数:84被引数:3,550
D
Daniel J. Antoine
H 指数:27论文数:145被引数:3,492