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W

Wolfgang Sippl

martin luther university halle wittenberg

64H指数
502论文数
1.4W被引数
收录论文 215
发表时间
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Novel Functionalized Pyrrolopyridines to Target Brk新型功能化吡咯并吡啶靶向Brk
errMolecules
IF4.6
err2026-08-17
err0
errOAAI
errErik Schmidt; Jannis von Veh; Anne-Christin Sarnow; Wolfgang Sippl; Julian Kowalski; Niels Heise; Frank Totzke; Andreas Hilgeroth
err分享
err收藏
Computational mapping of productive POI–E3 ligase conformations to guide de novo degrader design: application to WEE1 and PKMYT1 PROTACs计算生产性POI–E3连接酶构象的映射以指导从头降解剂设计：在WEE1和PKMYT1 PROTACs中的应用
errJournal of Cheminformatics
IF5.7
err2026-07-24
err0
errOAAI
errHusam Nassar; Matthias Schmidt; Hany S. Ibrahim; Dina Robaa; Wolfgang Sippl
err分享
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Synthesis, Biological Evaluation, and Molecular Docking Studies of 2r,3t,4c-Configured C-Furanosidic LpxC Inhibitors2R,3T,4C-构型C-呋喃糖基LpxC抑制剂的合成、生物评价及分子对接研究
errArchiv der Pharmazie
IF3.6
err2026-07-07
err0
errOAAI
errAndré Behnk; Fabian Lüttchens; Frederick Wichter; Katharina Hoff; Elisa Venanzi; Stefan Wimmer; Christopher Vorreiter; Katharina Rox; Wolfgang Sippl; Ralph Holl
err分享
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Identification of dual-targeting PROTACs for ataxia telangiectasia and RAD3-related and aurora kinase A as chemo-sensitizers for leukemia cells鉴定靶向共济失调性毛细血管扩张症和RAD3相关蛋白及Aurora激酶A的双靶点PROTACs作为白血病细胞的化学增敏剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-07-01
err0
PREAI
errAlfayomy, Abdallah M.; Neuroth, Sarah; Sarnow, Anne-Christin; Handke, Lukas; Robaa, Dina; Erdmann, Frank; Decroos, Christophe; Schmidt, Matthias; Romier, Chris; Schutkowski, Mike; Kramer, Oliver H.; Sippl, Wolfgang
err分享
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Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia急性巨核母细胞白血病中谱系限制性依赖于一个肿瘤-胚胎SNHG29-IGF2BP1 RNA轴
errLeukemia
IF13.4
err2026-06-30
err0
errOAAI
errRobert Winkler; Bruno Griesler; Wolfgang Sippl; Reinier A. Boon; Stefanie Dimmeler; Ilka Wittig; Marie-Laure Yaspo; Stefan Hüttelmaier; Raj Bhayadia; Dirk Heckl; Jan-Henning Klusmann
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Dual FLT3/MAPK14 Proteolysis-Targeting Chimera (PROTAC) Induces Potent Acute Myeloid Leukemia Cell Death双FLT3/MAPK14蛋白水解靶向嵌合体(PROTAC)诱导强效急性髓系白血病细胞死亡
errPharmaceuticals
IF4.8
err2026-05-13
err0
errOAAI
errMohamed Abdelsalam; Melisa Halilovic; Ramy Ashry; Husam Nassar; Frank Erdmann; Matthias Schmidt; Oliver H. Krämer; Wolfgang Sippl
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Advances in SIRT2-Targeted Therapeutics: Structural Insights, Chemical Strategies, and Degrader TechnologiesSIRT2靶向疗法的研究进展：结构洞见、化学策略与降解剂技术
errMedicinal Research Reviews
IF11.6
err2026-05-01
err0
PREAI
errAl-Karmalawy, Ahmed A.; Sippl, Wolfgang; Al-Dakhil, Abdullah; Yousef, Tarek A.; Khatib, Arwa Omar Al; Hawas, Samia S.
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Bisamidine Derivatives as Candidates for Tegumentary Leishmaniasis Therapy: Phenotypic Screening in Infection of Macrophages and Mechanistic Insights with Dual RNA-seq双脒类衍生物作为皮肤利什曼病治疗候选药物：巨噬细胞感染表型筛选与双RNA测序机制研究
errACS Omega
IF4.3
err2026-03-01
err0
errOAAI
errAgripino, Joice; Tahira, Ana C.; de Souza, Luciana Angelo; Silva e Bastos, Matheus; Sauer, Benjamin; Schmidt, Matthias; Bressan, Gustavo Costa; de Souza Vasconcellos, Raphael; Sippl, Wolfgang; Pierce, Raymond; Sena Amaral, Murilo; Verjovski-Almeida, Sergio; Rangel Fietto, Juliana Lopes
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Fragment-Based Design of Pseudo-Natural Products, Synthesis, and Evaluation of Their HIV-1 Latency-Reversing Properties基于片段的伪天然产物设计、合成及其逆转HIV-1潜伏期特性的评估
errChemical Biology & Drug Design
IF3.3
err2026-02-17
err0
PREAI
errTanyi, Solange A.; Eni, Donatus B.; Abdelsalam, Mohamed; Tjegbe, Mathieu J. M.; Schmidt, Matthias; Ndip, Roland N.; Tietjen, Ian; Sippl, Wolfgang; Ntie-Kang, Fidele
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Capsaicin-Inspired Hydroxamate Hybrids as Selective HDAC6 Inhibitors with Antiproliferative Activity in Hematological Malignancies辣椒素激发的异羟肟酸酯杂合体作为选择性HDAC6抑制剂，在血液系统恶性肿瘤中具有抗增殖活性
errACS Omega
IF4.3
err2026-01-28
err0
errOAAI
errLara Gimenez Borges; Thais Nascimento de Oliveira Alves; Sandra Valeria Vassiliades; Jorge Antonio Elias Godoy Carlos; Karoline de Barros Waitman; Sebastian Hilscher; Mike Schutkowski; Wolfgang Sippl; Maurício Temotheo Tavares; Monica Franco Zannini Junqueira Toledo; Letícia Veras Costa-Lotufo; Thales Kronenberger; João Agostinho Machado-Neto; Roberto Parise-Filho
err分享
err收藏
Inhibition of RNA-binding proteins enhances immunotherapy in ovarian cancer抑制RNA结合蛋白增强卵巢癌的免疫治疗
errSignal Transduction and Targeted Therapy
IF52.7
err2025-12-25
err0
errOAAI
errNadine Bley; Alexander Rausch; Simon Müller; Theresa Simon; Markus Glaß; Danny Misiak; Laura Schian; Lara Meret Peters; Mohammad Dipto; Ali Hmedat; Bianca Busch; Annekatrin Schott; Marcell Lederer; Alice Wedler; Robin Benedikt Rolnik; Hend Elrewany; Ehab Ghazy; Wolfgang Sippl; Martina Vetter; Markus Wallwiener; Stefan Hüttelmaier
err分享
err收藏
Design, synthesis and evaluation of novel oxadiazole-based compounds as potential Rac1 inhibitors against breast cancer基于噁二唑类化合物的设计、合成及其作为潜在Rac1抑制剂在乳腺癌中的应用评估
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-11-25
err0
PREAI
errAyca Erdogan; Dilruba Tirpanlar; Burcin Gungor; Enise Ece Gurdal; Wolfgang Sippl; Basak Aru; Gulderen Yanikkaya Demirel; Meric Koksal
err分享
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Revisiting soluble guanylate cyclase pharmacology: Additive potential of stimulators and activators重新审视可溶性鸟苷酸环化酶药理学：激动剂和激活剂的叠加潜力
errBiomedicine & Pharmacotherapy
IF7.5
err2025-11-18
err0
errOAAI
errAlexandra Petraina; Mahmoud H. Elbatreek; Christopher T. Neullens; Theodora Saridaki; Vu Thao-vi Dao; Rebecca D. Szepanowski; Emil Martin; Wolfgang Sippl; Ana I. Casas; Harald H.H.W. Schmidt
err分享
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African Natural Products Database (ANPDB): A resource for exploring the therapeutic potential of natural compounds from Africa非洲天然产物数据库（ANPDB）：用于探索非洲天然化合物治疗潜力的资源
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-11-01
err0
errOAAI
errBetow, Jude Y.; Qaseem, Ammar; Bekono, Boris D.; Feng, Yue; Moumbock, Aurelien F. A.; Simoben, Conrad, V; Babiaka, Smith B.; Tanyi, Solange A.; Shu, Vanessa A.; Ndi, Ariane T.; Onguene, Pascal Amoa; Metuge, Clovis S.; Akame, Simeon; Eni, Donatus B.; Namba-Nzanguim, Cyril T.; Tjegbe, Mathieu J. M.; Dikande, Marianka N. L.; Akeh, Patience T.; Balgah Jr, Sounders; Meh, Cyprian D.; Ibezim, Akachukwu; Tabi, Idris F.; Malange, Yvette, I; Ndingkokhar, Bakoh; Njume, Leonel E.; Telukunta, Kiran K.; Amrani, Said; Ebob, Oyere T.; Sippl, Wolfgang; Guenther, Stefan; Ntie-Kang, Fidele
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From Pharmacophore to Warhead: NAD+-Targeting Triazoles as Mechanism-Based Sirtuin Inhibitors从药效团到Warhead：靶向NAD+的三唑类作为机制性SirTuin抑制剂
errAngewandte Chemie International Edition
IF16.9
err2025-10-30
err0
errOAAI
errFlorian Friedrich; Dr. Marat Meleshin; Niklas Papenkordt; Lena Gaitzsch; Isabel Prucker; Dr. Marco Borso; Jan Ruprecht; Christopher Vorreiter; Sabrina Rast; Prof. Lin Zhang; Prof. Matthias Schiedel; Prof. Wolfgang Sippl; Prof. Axel Imhof; Prof. Henning J. Jessen; Prof. Oliver Einsle; Prof. Mike Schutkowski; Prof. Manfred Jung
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Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells鉴定靶向激活的检查点激酶-1的蛋白酶体靶向嵌合体揭示了其在肿瘤细胞中的非催化功能
errAngewandte Chemie International Edition
IF16.9
err2025-10-17
err0
errOAAI
errRamy Ashry; Dr. Mohamed Abdelsalam; Julia Hausen; Christoph Hieber; Dr. Yanira Zeyn; Anne-Christin Sarnow; Dr. Matthias Schmidt; Dr. Sara Najafi; Prof. Dr. Ina Oehme; Dr. Matthias Bros; Dr. Jia-Xuan Chen; Dr. Mario Dejung; Prof. Dr. Wolfgang Sippl; Prof. Dr. Oliver H. Krämer
err分享
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Substrate-Guided Development of HDAC11-Selective Inhibitors Featuring α-Amino Amide Zinc-Binding Groups基于底物引导的HDAC11选择性抑制剂开发：具有α-氨基酰胺锌结合基团
errACS Omega
IF4.3
err2025-10-13
err0
errOAAI
errSebastian Hilscher; Marat Meleshin; Fady Baselious; Cyril Barinka; Wolfgang Sippl; Mike Schutkowski; Cordelia Schiene-Fischer
err分享
err收藏
Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment多娜·弗洛尔与她的两个丈夫：用于髓系癌症治疗的HDAC6/AKT2新型抑制剂的发现
errComputers in Biology and Medicine
IF6.3
err2025-08-28
err0
PREAI
errKaroline B. Waitman; Holli-Joi Martin; Jorge A.E.G. Carlos; Rodolpho C. Braga; Vinícius A.M. Souza; Cleber C. Melo-Filho; Sebastian Hilscher; Mônica F.Z. J. Toledo; Maurício T. Tavares; Letícia V. Costa-Lotufo; João A. Machado-Neto; Mike Schutkowski; Wolfgang Sippl; Thales Kronenberger; Vinicius M. Alves; Roberto Parise-Filho; Eugene N. Muratov
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In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors基于计算机的筛选针对一个设计的聚焦化学空间，鉴定出新型烷基肼类化合物作为强效HDAC11抑制剂
errComputers in Biology and Medicine
IF6.3
err2025-07-04
err0
errOAAI
errFady Baselious; Sebastian Hilscher; Lukas Handke; Cyril Barinka; Mike Schutkowski; Wolfgang Sippl
err分享
err收藏
Histone Deacetylase Inhibitors Show a Potential Leishmanicidal Effect against Leishmania braziliensis in a Mouse Infection Model and Lead to Less Toxicity than Glucantime组蛋白去乙酰化酶抑制剂在鼠感染模型中对Leishmania braziliensis显示出潜在的杀利什曼原虫作用，且其毒性低于Glucantime。
errACS OMEGA
IF4.3
err2025-05-06
err0
errOAAI
errde Souza, LA; Andrade, LKR; Agripino, JD; da Silva, VHF; Emerick, SD; da Silva, AC; Pereira, LC; Lima, GDD; Garcia, IR; Souza, AC; Heimburg, T; da Silva, EDM; de Oliveira, LL; Ervilha, LOG; Machado-Neves, M; Bastos, MSE; Vasconcellos, RD; Bressan, G; Silva, A Jr; Pierce, RJ; Sippl, W; Fietto, JLR
err分享
err收藏

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