Raffi V. Aroian - Publications, H-index & Citations

Raffi V. Aroian

University of Massachusetts Chan Medical School

46H指数

133论文数

7.0K被引数

收录论文 56

发表时间

Methyl-HLH-30/TFEB orchestrates holistic intestinal recuperation against bacterial pore-forming toxin intoxication via TTC38 in metazoans 甲基-HLH-30/TFEB通过TTC38在多细胞动物中协调整体肠道修复以对抗细菌成孔毒素中毒

Autophagy

IF14.3

2026-09-23

OAAI

Hui-Chen Hsieh; Yi-Lin Cheng; Chyuan-Chuan Wu; Chee Kit Joshua Luk; Yi-Hsiu Weng; Tzu-Hsuan Chiu; Shao-Wen Chang; Ting-Wei Chang; Yan-Ning Gu; Jhen-Wei Ruan; Tzer-Min Lee; Shuying Wang; Po-Lin Chen; Raffi V. Aroian; Chang-Shi Chen

Catalytically Active Recombinant Cysteine Proteases of Haemonchus contortus: Their Ability to Degrade Host Blood Proteins and Modulate Coagulation 催化活性重组半胱氨酸蛋白酶的Haemonchus contortus：其降解宿主血液蛋白和调节凝血的能力

International Journal of Molecular Sciences 2025, Vol. 26, Page 12077

IF4.9

2025-12-16

OAAI

Athira C. Karunakaran; Mariam Bakshi; Arunraj M. Rajendrakumar; Jennifer H. Wilson-Welder; Raffi V. Aroian; Erich M. Schwarz; E. Jane Homan; Gary R. Ostroff; Ethiopia Beshah; Eliseo Miramontes; Marianne Dias Papadopoulos; Scott A. Bowdridge; Dante S. Zarlenga; Xiaoping Zhu; Wenbin Tuo

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections 源自激酶抑制剂SGI-1776的抗蠕虫药，用于治疗肠道蠕虫感染

ACS Infectious Diseases

IF3.8

2025-10-14

PREAI

Mostafa A. Elfawal; Victoria Banas; Bruce A. Rosa; Matthew Mahoney; Emily Goetz; Paulina Chen; Raffi V. Aroian; James W. Janetka; Makedonka Mitreva

Discovery of Human PIM Kinase Inhibitors as a Class of Anthelmintic Drugs to Treat Intestinal Nematode Infections

ACS INFECTIOUS DISEASES

IF3.8

2025-01-20

PREAI

Banas, Victoria; Elfawal, Mostafa A.; Rosa, Bruce A.; Mahoney, Matthew; Kauffman, Jacquelyn; Goetz, Emily; Chen, Paulina; Aroian, Raffi V.; Mitreva, Makedonka; Janetka, James W.

High-Throughput Screening of More Than 30,000 Compounds for Anthelmintics against Gastrointestinal Nematode Parasites

ACS INFECTIOUS DISEASES

IF3.8

2024-12-09

OAAI

Elfawal, Mostafa A.; Goetz, Emily; Kim, Youmie; Chen, Paulina; Savinov, Sergey N.; Barasa, Leonard; Thompson, Paul R.; Aroian, Raffi V.

Bacillus thuringiensis Cry14A family proteins as novel anthelmintics against gastrointestinal nematode parasites

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2024-10-25

OAAI

Hoang, Duy; Flanagan, Kelly; Ding, Qian; Cazeault, Nicholas R.; Li, Hanchen; Diaz-Valerio, Stefani; Rus, Florentina; Darfour, Esther A.; Kass, Elizabeth; Petersson, Katherine H.; Nielsen, Martin K.; Liesegang, Heiko; Ostroff, Gary R.; Aroian, Raffi V.

Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway

PLOS PATHOGENS

IF4.9

2024-10-18

OAAI

Kim, YouMie; Nguyen, Thanh-Thanh; Durning, Daniel J.; Ishidate, Takao; Aydemir, Ozkan; Mello, Craig C.; Hu, Yan; Kahn, Theodore W.; Aroian, Raffi V.

The nematode (Ascaris suum) intestine is a location of synergistic anthelmintic effects of Cry5B and levamisole

PLOS PATHOGENS

IF4.9

2024-05-17

OAAI

Williams, Paul D. E.; Brewer, Matthew T.; Aroian, Raffi V.; Robertson, Alan P.; Martin, Richard J.

PRMT-7/PRMT7 activates HLH-30/TFEB to guard plasma membrane integrity compromised by bacterial pore-forming toxins

AUTOPHAGY

IF14.3

2024-02-19

OAAI

Hsieh, Hui-Chen; Huang, I-Hsiang; Chang, Shao-Wen; Chen, Po-Lin; Su, Yu-Cheng; Wang, Shuying; Tsai, Wei-Jiun; Chen, Ping-Hung; Aroian, Raffi V.; Chen, Chang-Shi

An efficient method for viable cryopreservation and recovery of hookworms and other gastrointestinal nematodes in the laboratory

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2023-07-01

OAAI

Li, Hanchen; Gazzola, David; Hu, Yan; Aroian, Raffi, V

Anthelmintics V: Drugs, resistance, and vaccines

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2023-07-01

OAAI

Aroian, Raffi V.; Loukas, Alex; Martin, Richard J.

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains

PLOS PATHOGENS

IF4.9

2023-04-03

OAAI

Shaver, Amanda C.; Wit, Janneke; Dilks, Clayton; Crombie, Timothy; Li, Hanchen; Aroian, Raffi; Andersen, Erik

A Caenorhabditis elegans nck-1 and filamentous actin-regulating protein pathway mediates a key cellular defense against bacterial pore-forming proteins

PLOS PATHOGENS

IF4.9

2022-11-14

OAAI

Sitaram, Anand; Yin, Yunqiang; Zamaitis, Tammy; Zhang, Bo; Aroian, Raffi, V

Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis

MICROBIOLOGY SPECTRUM

IF3.8

2022-08-31

OAAI

Chicca, Jeffrey; Cazeault, Nicholas R.; Rus, Florentina; Abraham, Ambily; Garceau, Carli; Li, Hanchen; Atwa, Samar M.; Flanagan, Kelly; Soto, Ernesto R.; Morrison, Mary S.; Gazzola, David; Hu, Yan; Liu, David R.; Nielsen, Martin K.; Urban, Joseph F., Jr.; Ostroff, Gary R.; Aroian, Raffi V.

C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens

COMMUNICATIONS BIOLOGY

IF5.1

2022-06-30

OAAI

Ju, Shouyong; Chen, Hanqiao; Wang, Shaoying; Lin, Jian; Ma, Yanli; Aroian, Raffi V.; Peng, Donghai; Sun, Ming

Nematode ascarosides attenuate mammalian type 2 inflammatory responses

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-02-24

OAAI

Shinoda, Kenta; Choe, Andrea; Hirahara, Kiyoshi; Kiuchi, Masahiro; Kokubo, Kota; Ichikawa, Tomomi; Hoki, Jason S.; Suzuki, Akane S.; Bose, Neelanjan; Appleton, Judith A.; Aroian, Raffi, V; Schroeder, Frank C.; Sternberg, Paul W.; Nakayama, Toshinori

Immune reactivity and host modulatory roles of two novel Haemonchus contortus cathepsin B-like proteases 两种新的血友病组织蛋白酶B样蛋白酶的免疫反应性和宿主调节作用

PARASITES & VECTORS

IF3.5

2021-11-19

OAAI

Bakshi, Mariam; Tuo, Wenbin; Aroian, Raffi, V; Zarlenga, Dante

An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals

ONE HEALTH

IF4.5

2021-06-01

OAAI

Urban, Joseph F., Jr.; Nielsen, Martin K.; Gazzola, David; Xie, Yue; Beshah, Ethiopia; Hu, Yan; Li, Hanchen; Rus, Florentina; Flanagan, Kelly; Draper, Austin; Vakalapudi, Sridhar; Li, Robert W.; Ostroff, Gary R.; Aroian, Raffi, V

Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-02-17

OAAI

Li, Hanchen; Abraham, Ambily; Gazzola, David; Hu, Yan; Beamer, Gillian; Flanagan, Kelly; Soto, Ernesto; Rus, Florentina; Mirza, Zeynep; Draper, Austin; Vakalapudi, Sridhar; Stockman, Cheryl; Bain, Perry; Urban, Joseph F., Jr.; Ostroff, Gary R.; Aroian, Raffi, V

A new paraprobiotic-based treatment for control of Haemonchus contortus in sheep

INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE

IF3.4

2020-12-01

OAAI

Sanders, John; Xie, Yue; Gazzola, David; Li, Hanchen; Abraham, Ambily; Flanagan, Kelly; Rus, Florentina; Miller, Melanie; Hu, Yan; Guynn, Sierra; Draper, Austin; Vakalapudi, Sridhar; Petersson, Katherine H.; Zarlenga, Dante; Li, Robert W.; Urban, Joseph F., Jr.; Ostroff, Gary R.; Zajac, Anne; Aroian, Raffi, V

研究方向