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收藏分享 收藏 Building a platform of validated high throughput screening approaches for molecular glue degrader identification
Jordan, Allan; Addis, Philip; Allen, Toby; Ayra, Tarun; Beck, Sarah; Brant, Roslyn; Hjerpe, Roland; Gourdet, Benoit; Jennings, Martin; Lawrence, Rachel; Campbell-Maurer, Sigrun; Ng, Pei Cing; Parkinson, Lyn; Rejnowicz, Eva; Robles, Gonzalo; Rosethorne, Elizabeth; Shaw, Joshua; Smith, Duncan; Swift, Denise; Tait, Daniel; Thomson, Stuart; Tomlinson, Chris; Townley, Ailsa; Ward, Stephanie; Wilson, Clare 分享 收藏 分享 收藏 The Sygnature CHARMD platform - combinatorial high-throughput assembly and review of molecular degradersHjerpe, Roland; Birch, Louise; Brien, Alex; Cusin, Lola; Duffy, Lorna; Gourdet, Benoit; Lawrence, Rachel; MacFaul, Philip; Mortlock, Hannah; Neal, Hannah; Pearce, Christopher; Pitti, Erica; Robles, Gonzalo; Rodrigues, Edith; Scott, Catriona; Singh, Rajesh; Thomson, Stuart; Zhang, Yujia; Jordan, Allan 分享 收藏 分享 收藏 Identification of an orally bioavailable dual Cyclin K glue degrader-CDK12/13 inhibitorAinscow, Edward K.; Campbell, Adrian; Cripps, Michael; Workman, Robert; Thomson, Stuart; Chohan, Kam; Crepin, Damien; Sunose, Mahiro; Patient, Jamie; Kendrew, Jane; Bahl, Ash 分享 收藏 Targeting the p300/CBP Axis in Lethal Prostate Cancer靶向p300/CBP轴在致死性前列腺癌中的作用Welti, Jonathan; Sharp, Adam; Brooks, Nigel; Yuan, Wei; McNair, Christopher; Chand, Saswati N.; Pal, Abhijit; Figueiredo, Ines; Riisnaes, Ruth; Gurel, Bora; Rekowski, Jan; Bogdan, Denisa; West, William; Young, Barbara; Raja, Meera; Prosser, Amy; Lane, Jordan; Thomson, Stuart; Worthington, Jenny; Onions, Stuart; Shannon, Jonathan; Paoletta, Silvia; Brown, Richard; Smyth, Don; Harbottle, Gareth W.; Gil, Veronica S.; Miranda, Susana; Crespo, Mateus; Ferreira, Ana; Pereira, Rita; Tunariu, Nina; Carreira, Suzanne; Neeb, Antje J.; Ning, Jian; Swain, Amanda; Taddei, David; Schiewer, Matthew J.; Knudsen, Karen E.; Pegg, Neil; de Bono, Johann S. 分享 收藏 A high throughput screen of the novel immuno-oncology target HPK1 identifies a range of chemical starting points for the development of potent and selective inhibitorsSwift, Denise; Hitchin, Samantha; Tomlinson, Chris; Sengupta, Anindita; Taylor, Callum; O'Keeffe, Alec; Boden, Grace; Unitt, John; Thomson, Stuart; Jordan, Allan M. 分享 收藏 Developing sensitive assays to facilitate hit identification of RNA modifying enzymesTomlinson, Chris; Lawrence, Rachel; Best, Stuart; Boden, Grace; Alanine, Thomas; Wasp, James; Smith, Bethany; Wilkie, Ross; Thomson, Stuart; Unitt, John; Pollack, Scott; Jordan, Allan M. 分享 收藏 分享 收藏 CT7001: An orally bioavailable CDK7 inhibitor is a potential therapy for breast, small-cell lung and haematological cancersAinscow, Edward K.; Leishman, Andrew; Sullivan, Elaine; Li, Bo; Gallagher, William; Peall, Adam; Clark, Kristopher; Thomson, Stuart; Ali, Simak; Coombes, Raoul C.; Bahl, Ash 分享 收藏 分享 收藏 Reversible linkage of two distinct small molecule inhibitors of MYC generates a more potent and selective dimeric inhibitor that is active in cancer cell lines over-expressing MYCWanner, Jutta; Romashko, Darlene; Werner, Douglas S.; May, Earl W.; Peng, Yue; Schulz, Ryan; Foreman, Kenneth W.; Russo, Suzanne; Arnold, Lee D.; Pingle, Maneesh; Bergstrom, Donald E.; Barany, Francis; Thomson, Stuart 分享 收藏 分享 收藏 Inducible expression of TGFβ, Snail and Zeb1 recapitulates EMT in vitro and in vivo in a NSCLC modelArgast, Gretchen M.; Krueger, Joseph S.; Thomson, Stuart; Sujka-Kwok, Isabela; Carey, Krista; Silva, Stacia; O'Connor, Matthew; Mercado, Peter; Mulford, Iain J.; Young, G. David; Sennello, Regina; Wild, Robert; Pachter, Jonathan A.; Kan, Julie L. C.; Haley, John; Rosenfeld-Franklin, Maryland; Epstein, David M. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Preclinical evaluation of an EMT multi-gene biomarker index for predicting response to inhibitors of EGFR and IGF1RArgast, Gretchen M.; Bean, James; Wang, Jian; O'Connor, Matthew; Feng, Bin; Nicoletti, Richard; Lerner, Lorena; Heyer, Joerg; Chiu, Isabel; Robinson, Murray; Buck, Elizabeth; Thomson, Stuart; Kan, Julie L. C.; Haley, John D.; Epstein, David M. 分享 收藏 
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