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R

R. Charles Coombes

imperial college london
H指数:115
被引数:5.3万

个人简介

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教育背景

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工作经历

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荣誉奖项

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A randomized controlled trial of CDK7 inhibitor samuraciclib plus fulvestrant in advanced HR+/HER2− breast cancer

CDK7抑制剂Samuraciclib联合氟维司群治疗晚期HR+/HER2−乳腺癌的随机对照试验

Nature Communications
IF15.7
2026-10-050
OAAI
Sonia Pernas; Cengiz Karacin; Carlos Gonzalez-Nuñez; Sercan Aksoy; Meritxell Bellet Ezquerra; Nuri Karadurmus; Ozan Yazici; Maysa Abu-Khalaf; Begoña Bermejo de lasHeras; Marta Gonzalez Cordero; Mahmut Gumus; Carmen Hinojo; Rebeca Lozano Mejorada; Emmanuel de la Mora Jimenez; Carlos Zuloaga Fernandez del Valle; Cagatay Arslan; Shweta Kurian; María Martínez García; Daniel Motola-Kuba; Javier Pascual; Timothy Pluard; Gyongyver Szentmartoni; Glen Clack; Ash Bahl; Stuart McIntosh; Raoul Charles Coombes
Identification of actionable targets using DEPArray-based sorting of pure carcinoma and stromal populations from formalin-fixed paraffin-embedded tissues followed by shallow whole-genome sequencing

通过DEPArray辅助的固定石蜡包埋组织中纯癌和基质细胞群的分选，结合浅层全基因组测序，鉴定可操作靶点

The Journal of Pathology
IF5.2
2025-10-270
OAAI
Georgios Nteliopoulos; Evie Wren; Amelia Rushton; Marc K Wadsley; Daniel Fernandez-Garcia; Floriana Manodoro; Otis Agbaimoni; Ritika Chauhan; Zhao Cheng; Darren P Ennis; Karen Page; Rebecca C Allsopp; Joel Bautista; Ignazio Puccio; Nik Matthews; Kelly LT Gleason; Rehman Farah; Laura Kenny; Iain A McNeish; Jacqueline A Shaw; R Charles Coombes
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib (vol 14, 4444, 2023

CDK7抑制剂samuraciclib I期研究中，晚期乳腺癌患者的剂量递增和扩展队列（vol 14, 4444, 2023）

NATURE COMMUNICATIONS
IF15.7
2025-03-060
OA
Coombes, R. C.; Howell, Sacha; Lord, Simon R.; Kenny, Laura; Mansi, Janine; Mitri, Zahi; Chap, Linnea I.; Richards, Paul; Gradishar, William; Sardesai, Sagar; Melear, Jason; O'Shaughnessy, Joyce; Ward, Patrick; Chalasani, Pavani; Arkenau, Tobias; Baird, Richard D.; Jeselsohn, Rinath; Clack, Glen; Bahl, Ashwani; Mcintosh, Stuart; Krebs, Matthew G.
Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor-Targeted Therapy Drives Resistance in Breast Cancer
CANCER RESEARCH
IF16.6
2024-10-020
PRE
Gemma, Carolina; Lai, Chun-Fui; Singh, Anup K.; Belfiore, Antonino; Portman, Neil; Milioli, Heloisa Z.; Periyasamy, Manikandan; Raafat, Sara; Nicholls, Alyssa J.; Davies, Claire M.; Patel, Naina R.; Simmons, Georgia M.; Fan, Hailing; Nguyen, Van T. M.; Magnani, Luca; Rakha, Emad; Martin, Lesley-Ann; Lim, Elgene; Coombes, R. Charles; Pruneri, Giancarlo; Buluwela, Laki; Ali, Simak
Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study (Jan, 10.1007/s10549-023-07229-y, 2024)

一种新的基于光谱的激素受体阳性乳腺癌辅助治疗决策工具的性能: 一项验证研究 (1月，10.1007/s10549-023-07229-y，2024)

BREAST CANCER RESEARCH AND TREATMENT
IF3
2024-05-050
OAAI
Coombes, R. Charles; Angelou, Christina; Al-Khalili, Zamzam; Hart, William; Francescatti, Darius; Wright, Nicholas; Ellis, Ian; Green, Andrew; Rakha, Emad; Shousha, Sami; Amrania, Hemmel; Phillips, Chris C.; Palmieri, Carlo
Performance of a novel spectroscopy-based tool for adjuvant therapy decision-making in hormone receptor-positive breast cancer: a validation study

一种新的基于光谱的激素受体阳性乳腺癌辅助治疗决策工具的性能: 一项验证研究

BREAST CANCER RESEARCH AND TREATMENT
IF3
2024-01-203
OAAI
Coombes, Charles; Angelou, Christina; Al-Khalili, Zamzam; Hart, William; Francescatti, Darius; Wright, Nicholas; Ellis, Ian; Green, Andrew; Rakha, Emad; Shousha, Sami; Amrania, Hemmel; Phillips, Chris C.; Palmieri, Carlo
Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib
NATURE COMMUNICATIONS
IF15.7
2023-07-2418
OAAI
Coombes, R. Charles; Howell, Sacha; Lord, Simon R.; Kenny, Laura; Mansi, Janine; Mitri, Zahi; Palmieri, Carlo; Chap, Linnea I.; Richards, Paul; Gradishar, William; Sardesai, Sagar; Melear, Jason; O'Shaughnessy, Joyce; Ward, Patrick; Chalasani, Pavani; Arkenau, Tobias; Baird, Richard D.; Jeselsohn, Rinath; Ali, Simak; Clack, Glen; Bahl, Ashwani; McIntosh, Stuart; Krebs, Matthew G.
Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer
ONCOGENE
IF7.3
2022-10-0514
OAAI
Harrod, Alison; Lai, Chun-Fui; Goldsbrough, Isabella; Simmons, Georgia M.; Oppermans, Natasha; Santos, Daniela B.; Gyorffy, Balazs; Allsopp, Rebecca C.; Toghill, Bradley J.; Balachandran, Kirsty; Lawson, Mandy; Morrow, Christopher J.; Surakala, Manasa; Carnevalli, Larissa S.; Zhang, Pei; Guttery, David S.; Shaw, Jacqueline A.; Coombes, R. Charles; Buluwela, Lakjaya; Ali, Simak
Study of samuraciclib (CT7001), a first-in-class, oral, selective inhibitor of CDK7, in combination with fulvestrant in patients with advanced hormone receptor positive HER2 negative breast cancer (HR plus BC)
CANCER RESEARCH
IF16.6
2022-02-152
PRE
Coombes, Charles; Howell, Sasha J.; Krebs, Matthew G.; Lord, Simon; Kenny, Laura M.; Bahl, Ash; Clack, Glen; Ainscow, Edward; Dickinson, Paul A.; Fostea, Raluca; Mansi, Janine; Palmieri, Carlo; Bertelli, Gianflippo; Jeselsohn, Rinath; Mitri, Zahi; Gradishar, William J.; Sardesai, Sagar; O'Shaughnessy, Joyce; Ward, Patrick; Chalasani, Pavani; Lehnert, Manfred; Ali, Simak; McIntosh, Stuart

研究方向

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S
Simak Ali
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C
Carlo Palmieri
H 指数:45论文数:395被引数:1.0万
J
Justin Stebbing
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E
Eric W.‐F. Lam
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E
Eric O. Aboagye
H 指数:67论文数:672被引数:1.8万
S
Sami Shousha
H 指数:46论文数:275被引数:6,711
K
Karen Page
H 指数:35论文数:104被引数:4,423
L
Laura Kenny
H 指数:27论文数:95被引数:2,979
J
Judith M. Bliss
H 指数:90论文数:805被引数:3.8万
D
David S. Guttery
H 指数:39论文数:125被引数:5,206