David J. Vocadlo - Publications, H-index & Citations

David J. Vocadlo

simon fraser university

66H指数

305论文数

1.7W被引数

收录论文 129

发表时间

Pharmacological inhibition of O-GlcNAcase reduces pS129-α-synuclein positive aggregates in the substantia nigra of mThy1-hSNCA mice 药理学抑制O-GlcNAcase可减少mThy1-hSNCA小鼠黑质中pS129-α-synuclein阳性的聚集物。

Journal of Parkinson’s Disease

IF0

2026-02-10

PREAI

Jefferey Yue; Bryan Jones; Kim H Tran; Matthew Deen; Viktor Holicek; Wai Hang Cheng; Mateusz Michalik; Sarah Power; Cheryl L Wellington; Neil V Watson; David J Vocadlo

A proto-aldehyde fluorescence quenched substrate for quantitative imaging of both protein and enzyme activity within cells 一种原醛荧光猝灭底物，用于定量成像细胞内的蛋白质和酶活性

Chem. Sci.

IF7.4

2025-10-29

OAAI

Sha Zhu ‡; Matthew C. Deen ‡; Samy Cecioni §; Kim Lam Wong; Evan Perley-Roberston; Weifeng Benny Wu; David J. Vocadlo

A Genetically Encoded Assay System to Quantify O-GlcNAc Transferase (OGT) Activity in Live Cells 一种用于定量活细胞中O-GlcNAc转移酶（OGT）活性的遗传编码分析系统

Angewandte Chemie International Edition

IF0

2025-09-15

OAAI

Weifeng Benny Wu; Dr. Yanping Zhu; Jun Bian; Jil Busmann; Prof. David Vocadlo

Enzyme Activity-Based Genome-wide Screening for Modifiers of Lysosomal Glucocerebrosidase Uncovers Candidate Risk Factors for Parkinson’s Disease 基于酶活性的全基因组筛选法用于鉴定溶酶体葡糖脑苷酶修饰因子，发现了帕金森病的候选风险因素

ACS Central Science

IF10.4

2025-09-03

OAAI

Vinod Udayar; Pierre-André Gilormini; Julien Bryois; Alexandra Gehrlein; Xi Chen; Stephanie Sonea; Sha Zhu; Matthew C. Deen; Nadia Anastasi; Alan E. Murphy; Nathan Skene; Manuela M. X. Tan; Jon-Anders Tunold; Filip Roudnicky; Wilma D. J. van de Berg; Lasse Pihlstrøm; David J. Vocadlo; Ravi Jagasia

A dual-functional substrate for quantitation of substrate levels and GCase activity in living cells 一种用于定量分析底物水平和GCase活性的双功能基质

RSC Chem. Biol.

IF3.1

2025-08-06

OAAI

Ben Tiet; Sha Zhu; Xi Chen; Nadia Anastasi; Nicholas W. See; Matthew C. Deen; Eva Harde; David J. Vocadlo

Sleep Characterization in the APP/NL-F Mouse Model of Alzheimer's Disease After Repetitive Mild Traumatic Brain Injuries 阿尔茨海默病APP/NL-F小鼠模型在重复性轻度创伤性脑损伤后的睡眠特征研究

SLEEP

IF4.9

2025-05-19

PREAI

Carriquiriborde, Victoria; Yue, Jefferey; Yildirim, Taha; Shams, Emad; Cheng, Wai Hang; Tok, Sean; Vocadlo, David J.; Wellington, Cheryl L.; Kent, Brianne A.

A gram-scale synthesis of β-L-carbafucose for engineering antibody glycans 克级规模β-L-羰基岩藻糖的合成及其在抗体糖基工程中的应用

COMMUNICATIONS CHEMISTRY

IF6.2

2025-05-06

OAAI

Thota, V. Narasimharao; Fers-Lidou, Anthony; Nodwell, Matthew; Mcdonagh, Anthony W.; Gilormini, Pierre-Andre; Wang, Yang; Leung, Carolyn; Vocadlo, David J.; Britton, Robert

Expansion of the diversity of dispersin scaffolds 分散素支架多样性的扩展

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

IF3.8

2025-02-28

OAAI

Males, A; Moroz, OV; Blagova, E; Munch, A; Hansen, GH; Johansen, A; Ostergaard, LH; Segura, DR; Eddenden, A; Due, AV; Gudmand, M; Salomon, J; Sorensen, SR; Cairo, JPLF; Nitz, M; Pache, RA; Vejborg, RM; Bhosale, S; Vocadlo, DJ; Davies, GJ; Wilson, KS

An Efficient and Accessible Hectogram-Scale Synthesis for the Selective O-GlcNAcase Inhibitor Thiamet-G

ACS OMEGA

IF4.3

2024-12-08

PREAI

Holicek, Viktor; Deen, Matthew; Bhosale, Sandeep; Ashmus, Roger A.; Vocadlo, David J.

A self-immolative Kdn-glycoside substrate enables high-throughput screening for inhibitors of Kdnases

GLYCOBIOLOGY

IF3.3

2024-11-21

OAAI

Nejatie, Ali; Proceviat, Cameron; Gros, Christina; Steves, Elizabeth; Moore, Margo M.; Vocadlo, David J.; Bennet, Andrew J.

Direct and indirect regulation of β-glucocerebrosidase by the transcription factors USF2 and ONECUT2 转录因子USF2和ONECUT2对 β-葡糖脑苷脂酶的直接和间接调控

NPJ PARKINSONS DISEASE

IF8.2

2024-10-22

OAAI

Ging, Kathi; Frick, Lukas; Schlachetzki, Johannes; Armani, Andrea; Zhu, Yanping; Gilormini, Pierre-Andre; Dhingra, Ashutosh; Boeck, Desiree; Marques, Ana; Deen, Matthew; Chen, Xi; Serdiuk, Tetiana; Trevisan, Chiara; Sellitto, Stefano; Pisano, Claudio; Glass, Christopher K.; Heutink, Peter; Yin, Jiang-An; Vocadlo, David J.; Aguzzi, Adriano

High- throughput screening for small- molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease 高通量筛选戈谢病和帕金森病中错误折叠葡糖脑苷脂酶小分子稳定剂

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-10-10

OAAI

Williams, Darian; Glasstetter, Logan M.; Jong, Tiffany T.; Chen, Tiffany; Kapoor, Abhijeet; Zhu, Sha; Zhu, Yanping; Calvo, Raul; Gehrlein, Alexandra; Wong, Kimberly; Hogan, Andrew N.; Vocadlo, David J.; Jagasia, Ravi; Marugan, Juan J.; Sidransky, Ellen; Henderson, Mark J.; Chen, Yu

Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates

ACS CATALYSIS

IF13.1

2024-09-20

OAAI

Bhosale, Sandeep; Kandalkar, Sachin; Gilormini, Pierre-Andre; Akintola, Oluwafemi; Rowland, Rhianna; Adabala, Pal John Pal; King, Dustin; Deen, Matthew C.; Chen, Xi; Davies, Gideon J.; Vocadlo, David J.; Bennet, Andrew J.

A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-06-25

PREAI

Gilormini, Pierre-Andre; Thota, V. Narasimharao; Fers-Lidou, Anthony; Ashmus, Roger A.; Nodwell, Matthew; Brockerman, Jacob; Kuo, Chu-Wei; Wang, Yang; Gray, Taylor E.; Nitin; McDonagh, Anthony W.; Guu, Shih-Yun; Ertunc, Nursah; Yeo, Dominick; Zandberg, Wesley F.; Khoo, Kay-Hooi; Britton, Robert; Vocadlo, David J.

Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes

NATURE BIOTECHNOLOGY

IF41.7

2024-05-14

PREAI

Wu, Taiasean; Yu, Joshua C.; Suresh, Arundhati; Gale-Day, Zachary J.; Alteen, Matthew G.; Woo, Amanda S.; Millbern, Zoe; Johnson, Oleta T.; Carroll, Emma C.; Partch, Carrie L.; Fourches, Denis; Vinueza, Nelson R.; Vocadlo, David J.; Gestwicki, Jason E.

Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-12-01

OAAI

Pratt, Matthew R.; Vocadlo, David J.

Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo

CURRENT OPINION IN CHEMICAL BIOLOGY

IF6.1

2023-12-01

PREAI

Deen, Matthew C.; Gilormini, Pierre-Andre; Vocadlo, David J.

Phage display uncovers a sequence motif that drives polypeptide binding to a conserved regulatory exosite of O-GlcNAc transferase

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-10-11

OAAI

Alteen, Matthew G.; Meek, Richard W.; Kolappan, Subramania; Busmann, Jil A.; Cao, Jessica; O'Gara, Zoe; Chou, Ying; Derda, Ratmir; Davies, Gideon J.; Vocadlo, David J.

Human O-GlcNAcase Uses a Preactivated Boat-skew Substrate Conformation for Catalysis. Evidence from X-ray Crystallography and QM/MM Metadynamics

ACS CATALYSIS

IF13.1

2023-10-10

OAAI

Calvelo, Martin; Males, Alexandra; Alteen, Matthew G.; Willems, Lianne I.; Vocadlo, David J.; Davies, Gideon J.; Rovira, Carme

A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae

ACS CHEMICAL BIOLOGY

IF3.8

2023-08-02

PREAI

Bhosale, Sandeep; Deen, Matthew C.; Proceviat, Cameron; Hettle, Andrew; Winter, Dana K.; Brockerman, Jacob; Levene, Marina; Bennet, Andrew J.; Spino, Claude; Boraston, Alisdair B.; Vocadlo, David J.

研究方向