未登录 A recurrent ACAA2 variant causes a dominant syndrome of lipodystrophy, lipomatosis, infantile steatohepatitis, and hypoglycemia Simha, V.; LoPiccolo, M.K.; Platt, A.; Brown, R.J.; Johnson, X.; Carere, D.A.; Donnelly, C.; Snyder, M.T.; Xing, C.; Mathews, T.P.; 等. 一种复发性ACAA2变异导致一种显性综合征，其特征为脂肪营养不良、脂肪瘤病、婴儿期脂肪肝和低血糖。J. Clin. Investig. 2026, 136, e198888. [Google Scholar] [CrossRef] [PubMed] Simha, Vinaya; LoPiccolo, Mary Kate; Platt, Anna; Brown, Rebecca J.; Johnson, Xandria; Carere, Deanna Alexis; Donnelly, Colleen; Snyder, Matthew T.; Xing, Chao; Mathews, Thomas P.; Gopal, Purva; Ward, Stephen C.; Tomchick, Diana R.; Agarwal, Anil K.; DeBerardinis, Ralph J.; Garg, Abhimanyu 分享 收藏
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Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention Nie, Zhe; Bonnert, Roger; Tsien, Jet; Deng, Xiaoyi; Higgs, Christopher; El Mazouni, Farah; Zhang, Xiaoyu; Li, Renzhe; Ho, Nhi; Feher, Victoria; Paulsen, Janet; Shackleford, David M.; Katneni, Kasiram; Chen, Gong; Ng, Alice C. F.; Mcinerney, Mitchell; Wang, Wen; Saunders, Jessica; Collins, Daniel; Yan, Dandan; Li, Peng; Campbell, Michael; Patil, Rahul; Ghoshal, Atanu; Mondal, Pallab; Kundu, Abhijit; Chittimalla, Rajesh; Mahadeva, Muralikumar; Kokkonda, Sreekanth; White, John; Das, Rishi; Mukherjee, Partha; Angulo-Barturen, Inigo; Belen Jimenez-Diaz, Maria; Malmstrom, Robert; Lawrenz, Morgan; Rodriguez-Granillo, Agustina; Rathod, Pradipsinh K.; Tomchick, Diana R.; Palmer, Michael J.; Laleu, Benoit; Qin, Tian; Charman, Susan A.; Phillips, Margaret A. 分享 收藏
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Identification of FDA-approved drugs that induce heart regeneration in mammals Ahmed, Mahmoud Salama; Nguyen, Ngoc Uyen Nhi; Nakada, Yuji; Hsu, Ching-Cheng; Farag, Ayman; Lam, Nicholas T.; Wang, Ping; Thet, Suwannee; Menendez-Montes, Ivan; Elhelaly, Waleed M.; Lou, Xi; Secco, Ilaria; Tomczyk, Mateusz; Zentilin, Lorena; Pei, Jimin; Cui, Miao; Dos Santos, Matthieu; Liu, Xiaoye; Liu, Yan; Zaha, David; Walcott, Gregory; Tomchick, Diana R.; Xing, Chao; Zhang, Cheng Cheng; Grishin, Nick V.; Giacca, Mauro; Zhang, Jianyi; Sadek, Hesham A. 分享 收藏
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Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii Russo, Thomas A.; Umland, Timothy C.; Deng, Xiaoyi; El Mazouni, Farah; Kokkonda, Sreekanth; Olson, Ruth; Carlino-MacDonald, Ulrike; Beanan, Janet; Alvarado, Cassandra L.; Tomchick, Diana R.; Hutson, Alan; Chen, Hong; Posner, Bruce; Rathod, Pradipsinh K.; Charman, Susan A.; Phillips, Margaret A. 分享 收藏
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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series Palmer, Michael J.; Deng, Xiaoyi; Watts, Shawn; Krilov, Goran; Gerasyuto, Aleksey; Kokkonda, Sreekanth; El Mazouni, Farah; White, John; White, Karen L.; Striepen, Josefine; Bath, Jade; Schindler, Kyra A.; Yeo, Tomas; Shackleford, David M.; Mok, Sachel; Deni, Ioanna; Lawong, Aloysus; Huang, Ann; Chen, Gong; Wang, Wen; Jayaseelan, Jaya; Katneni, Kasiram; Patil, Rahul; Saunders, Jessica; Shahi, Shatrughan P.; Chittimalla, Rajesh; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Wittlin, Sergio; Tumwebaze, Patrick K.; Rosenthal, Philip J.; Cooper, Roland A.; Aguiar, Anna Caroline Campos; Guido, Rafael V. C.; Pereira, Dhelio B.; Mittal, Nimisha; Winzeler, Elizabeth A.; Tomchick, Diana R.; Laleu, Benoit; Burrows, Jeremy N.; Rathod, Pradipsinh K.; Fidock, David A.; Charman, Susan A.; Phillips, Margaret A. 分享 收藏
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A distinct inhibitory mechanism of the V-ATPase by Vibrio VopQ revealed by cryo-EM Peng, Wei; Casey, Amanda K.; Fernandez, Jessie; Carpinone, Emily M.; Servage, Kelly A.; Chen, Zhe; Li, Yang; Tomchick, Diana R.; Starai, Vincent J.; Orth, Kim 分享 收藏
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Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria Kokkonda, Sreekanth; Deng, Xiaoyi; White, Karen L.; El Mazouni, Farah; White, John; Shackleford, David M.; Katneni, Kasiram; Chiu, Francis C. K.; Barker, Helena; McLaren, Jenna; Crighton, Elly; Chen, Gong; Angulo-Barturen, Inigo; Jimenez-Diaz, Maria Belen; Ferrer, Santiago; Valentin, Leticia Huertas; Martinez-Martinez, Maria S.; Lafuente-Monasterio, Maria Jose; Kumar, Chittimalla R.; Shahi, Shatrughan P.; Wittlin, Sergio; Waterson, David; Burrows, Jeremy N.; Matthews, Dave; Tomchick, Diana R.; Rathod, Pradipsinh K.; Palmer, Michael J.; Charman, Susan A.; Phillips, Margaret A. 分享 收藏
Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function Zhong, Xue; Su, Lijing; Yang, Yi; Nair-Gill, Evan; Tang, Miao; Anderton, Priscilla; Li, Xiaohong; Wang, Jianhui; Zhan, Xiaoming; Tomchick, Diana R.; Brautigam, Chad A.; Moresco, Eva Marie Y.; Choi, Jin Huk; Beutler, Bruce 分享 收藏
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