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D

Dwight V. Nissley

Frederick National Laboratory for Cancer Research

29H指数
169论文数
5.0K被引数
收录论文 73
发表时间
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Structural mechanisms underlying resistance to Switch-II pocket inhibitors in KRASKRAS中抗Switch-II口袋抑制剂的分子结构机制
errNature Communications
IF15.7
err2026-09-29
err0
errOAAI
errMatthew J. Whitley; Marcin Dyba; Mayukh Chakrabarti; Brian P. Smith; Albert H. Chan; John-Paul Denson; Simon A. Messing; Ken Lin; Gabriel Cornilescu; Trent E. Balius; Dwight V. Nissley; Frank McCormick; Anna E. Maciag; Dhirendra K. Simanshu
err分享
err收藏
Free Energy and Flexibility Analysis of Autoinhibited Human BRAF人类BRAF自抑制状态的自由能和柔韧性分析
errJournal of Chemical Information and Modeling
IF5.3
err2026-04-21
err0
errOAAI
errJeremy O. B. Tempkin; Fikret Aydin; Sebnem Essiz; Yue Yang; Timothy S. Carpenter; David E. Durrant; Deborah K. Morrison; Helgi I. Ingólfsson; Frederick H. Streitz; Dwight V. Nissely; Felice C. Lightstone; Xiaohua Zhang
err分享
err收藏
Disulfide tethering reveals cryptic pockets in oncogenic KRAS二硫键连接技术揭示了致癌性KRAS中的隐匿口袋
errCommunications Chemistry
IF6.2
err2026-03-30
err0
errOAAI
errTrent E. Balius; Marcin Dyba; Vandana Kumari; John-Paul Denson; Ming Yi; Alok K. Sharma; Priyanka Prakash; Emily Alberico; Simon Messing; Vanessa Wall; Albert H. Chan; Dhirendra K. Simanshu; Dwight V. Nissley; Frank McCormick; Dominic Esposito; Anna E. Maciag; David M. Turner
err分享
err收藏
Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitorsSHOC2-KRAS-PP1C复合物的结构揭示了RAS亚型特异性的决定因素以及RAS抑制剂靶向复合物组装的见解
errNature Communications
IF15.7
err2026-01-10
err0
errOAAI
errDaniel A. Bonsor; Lorenzo I. Finci; Jacob R. Potter; Lucy C. Young; Vanessa E. Wall; Ruby Goldstein de Salazar; Katie R. Geis; Tyler Stephens; Joseph Finney; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu
err分享
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Integrating Ultra-Coarse-Grained Protein Models into Accessible Workflows for Multiscale Molecular Dynamics将超粗粒化蛋白质模型整合到可访问的多尺度分子动力学工作流程中
errACS Omega
IF4.3
err2025-10-22
err0
errOAAI
errBryce Tu Chi; Stephanie Fulcar; Jonathan Ipe; Olivia Schleifer; Rohan Subramanian; Claire Vlases; Naim Matasci; Konstantia Georgouli; Loïc Pottier; Tim Hsu; Timothy S. Carpenter; Dwight V. Nissley; Felice C. Lightstone; Frederick H. Streitz; Helgi I. Ingólfsson; Fikret Aydin
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Structural basis for LZTR1 recognition of RAS GTPases for degradationLZTR1识别RAS GTPases以促进其降解的结构基础
errScience
IF45.8
err2025-09-11
err0
PREAI
errSrisathiyanarayanan Dharmaiah; Daniel A. Bonsor; Stephanie P. Mo; Alvaro Fernandez-Cabrera; Albert H. Chan; Simon Messing; Matthew Drew; Martha Vega; Dwight V. Nissley; Dominic Esposito; Pau Castel; Dhirendra K. Simanshu
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Dynamics and lipid membrane coupling of the RAS-RAF complex revealed via multiscale simulationsRAS-RAF复合物的动力学及与脂质膜的耦合关系通过多尺度模拟揭示
errBiophysical Journal
IF3.1
err2025-08-22
err0
errOAAI
errTimothy S. Carpenter; Fikret Aydin; Chris Neale; Que N. Van; Xiaohua Zhang; Harsh Bhatia; Jason W. Sidabras; Peter H. Frank; Konstantia Georgouli; Jeremy O.B. Tempkin; Violeta Burns Casamayor; Gulcin Gulten; Rebika Shrestha; Debanjan Goswami; Francesco Di Natale; Joseph R. Chavez; Adam Moody; Joseph Y. Moon; Tomas Oppelstrup; James N. Glosli; Gautham Dharuman; Sergio Wong; Shusen Liu; Nicolas W. Hengartner; Cesar A. López; Kien Nguyen; Christopher B. Stanley; Liam G. Stanton; Lara Patel; Tyler Reddy; Thomas J. Turbyville; Brian Van Essen; Peer-Timo Bremer; Felice C. Lightstone; Andrew G. Stephen; Sandrasegaram Gnanakaran; Frank McCormick; Dwight V. Nissley; Frederick H. Streitz; Helgi I. Ingólfsson
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err收藏
Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraintsKRAS开关-II口袋抑制剂的生物物理和结构分析揭示了等位基因特异性的结合限制
errJournal of Biological Chemistry
IF3.9
err2025-07-01
err0
errOAAI
errPatrick Alexander; Albert H. Chan; Dana Rabara; Monalisa Swain; Erik K. Larsen; Marcin Dyba; Oleg Chertov; Mariam Ashraf; Allison Champagne; Ken Lin; Anna Maciag; William K. Gillette; Dwight V. Nissley; Frank McCormick; Dhirendra K. Simanshu; Andrew G. Stephen
err分享
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BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interactionBBO-10203通过阻断RAS-PI3Kα相互作用抑制肿瘤生长，而不诱导高血糖症
errScience
IF45.8
err2025-06-12
err0
PREAI
errDhirendra K. Simanshu; Rui Xu; James P. Stice; Daniel J. Czyzyk; Siyu Feng; John-Paul Denson; Erin Riegler; Yue Yang; Cathy Zhang; Sofia Donovan; Brian P. Smith; Maria Abreu-Blanco; Ming Chen; Cindy Feng; Lijuan Fu; Dana Rabara; Lucy C. Young; Marcin Dyba; Wupeng Yan; Ken Lin; Samar Ghorbanpoorvalukolaie; Erik K. Larsen; Wafa Malik; Allison Champagne; Katie Parker; Jin Hyun Ju; Stevan Jeknic; Dominic Esposito; David M. Turner; Felice C. Lightstone; Bin Wang; Paul M. Wehn; Keshi Wang; Andrew G. Stephen; Anna E. Maciag; Aaron N. Hata; Kerstin W. Sinkevicius; Dwight V. Nissley; Eli M. Wallace; Frank McCormick; Pedro J. Beltran
err分享
err收藏
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine通过直接共价攻击CaaX盒半胱氨酸来阻断KRAS4b的C末端加工
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-09
err0
errOAAI
errMaciag, Anna E.; Yang, Yue; Sharma, Alok K.; Turner, David M.; Dehart, Caroline J.; Abdelkarim, Hazem; Fan, Lixin; Smith, Brian P.; Kumari, Vandana; Dyba, Marcin; Rigby, Megan; Badillo, Jean A. Castillo; Adams, Lauren; Fornelli, Luca; Fox, Stephen; Brafman, Alla; Turbyville, Thomas; Gillette, William; Messing, Simon; Agamasu, Constance; Wolfe, Andrew L.; Gysin, Stephan; Chan, Albert H.; Simanshu, Dhirendra K.; Esposito, Dominic; Chertov, Oleg; Stephen, Andrew G.; Arkin, Michelle; Renslo, Adam; Kelleher, Neil L.; Gaponenko, Vadim; Lightstone, Felice C.; Nissley, Dwight, V; McCormick, Frank
err分享
err收藏
Enhanced Exploration of Protein Conformational Space through Integration of Ultra-Coarse-Grained Models to Multiscale Workflows通过将超粗粒度模型集成到多尺度工作流程中增强蛋白质构象空间的探索
errJOURNAL OF PHYSICAL CHEMISTRY B
IF2.9
err2025-05-08
err0
errOAAI
errAydin, Fikret; Georgouli, Konstantia; Pottier, Loic; Oppelstrup, Tomas; Carpenter, Timothy S.; Tempkin, Jeremy O. B.; Bremer, Peer-Timo; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.
err分享
err收藏
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation结构洞察：异构体特异性的RAS-PI3Kα相互作用及其RAS在PI3Kα激活中的作用
errNATURE COMMUNICATIONS
IF15.7
err2025-01-09
err0
errOAAI
errCzyzyk, Daniel; Yan, Wupeng; Messing, Simon; Gillette, William; Tsuji, Takashi; Yamaguchi, Mitsuhiro; Furuzono, Shinji; Turner, David M.; Esposito, Dominic; Nissley, Dwight V.; Mccormick, Frank; Simanshu, Dhirendra K.
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The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations
errSCIENTIFIC REPORTS
IF3.9
err2024-10-26
err0
errOAAI
errYi, Ming; Soppet, Daniel; Mccormick, Frank; Nissley, Dwight V.
err分享
err收藏
Generating Protein Structures for Pathway Discovery Using Deep Learning
errJOURNAL OF CHEMICAL THEORY AND COMPUTATION
IF5.5
err2024-10-10
err0
errOAAI
errGeorgouli, Konstantia; Stephany, Robert R.; Tempkin, Jeremy O. B.; Santiago, Claudio; Aydin, Fikret; Heimann, Mark A.; Pottier, Loic; Zhang, Xiaohua; Carpenter, Timothy S.; Hsu, Tim; Nissley, Dwight V.; Streitz, Frederick H.; Lightstone, Felice C.; Ingolfsson, Helgi I.; Bremer, Peer-Timo
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err收藏
BBO-10203, an orally bioavailable small molecule that disrupts the RAS-PI3Kα interaction leading to pAKT and tumor growth inhibition in models of breast, lung and colorectal cancer
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errSimanshu, D.; Xu, R.; Stice, J.; Czyzyk, D.; Feng, S.; Yang, Y.; Denson, J. P.; Riegler, E.; Zhang, C.; Fu, L.; Lin, K.; Lightstone, F. C.; Wang, K.; Stephen, A. G.; Maciag, A. E.; Sinkevicius, K.; Nissley, D. V.; Wallace, E. M.; McCormick, F.; Beltran, P.
err分享
err收藏
BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS- driven PI3Kalpha activity without affecting glucose metabolism
errCANCER RESEARCH
IF16.6
err2024-05-02
err1
PREAI
errBeltran, Pedro; Dhirendra, Simanshu; Xu, Rui; Chen, Ming; Czyzyk, Daniel; Donovan, Sofia; Feng, Siyu; Feng, Cindy; Fu, Lijuan; Lightstone, Felice; Lin, Ken; Maciag, Anna; Nissley, Dwight; Riegler, Erin; Sinkevicius, Kerstin; Stephen, Andrew; Stice, James; Turner, David; Wang, Bin; Wang, Keshi; Yang, Yue; Zhang, Cathy; McCormick, Frank; Wallace, Eli
err分享
err收藏
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane (vol 7, 242 , 2024)
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-04-11
err0
errOAAI
errShrestha, Rebika; Carpenter, Timothy S.; Van, Que N.; Agamasu, Constance; Tonelli, Marco; Aydin, Fikret; Chen, De; Gulten, Gulcin; Glosli, James N.; Lopez, Cesar A.; Oppelstrup, Tomas; Neale, Chris; Gnanakaran, Sandrasegaram; Gillette, William K.; Ingolfsson, Helgi I.; Lightstone, Felice C.; Stephen, Andrew G.; Streitz, Frederick H.; Nissley, Dwight V.; Turbyville, Thomas J.
err分享
err收藏
BBO-8520, a first-in-class, direct inhibitor of KRASG12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding
errCANCER RESEARCH
IF16.6
err2024-04-05
err2
PREAI
errMaciag, Anna E.; Stice, James; Wang, Bin; Sharma, Alok; Chan, Albert; Lin, Ken; Singh, Devansh; Dyba, Marcin; Yang, Yue; Setoodeh, Saman; Smith, Brian P.; Rabara, Dana; Zhang, Zuhui; Larsen, Erik K.; Esposito, Dom; Denson, John Paul; Ranieri, Michela; Meynardie, Mary; Mehdizadeh, Sadaf; Alexander, Patrick; Blanco, Maria Abreu; Turner, David; Xu, Rui; Lightstone, Felice C.; Wong, Kwok Kin; Simanshu, Dhirendra; Wang, Keshi; Stephen, Andrew G.; Sinkevicius, Kerstin; Nissley, Dwight V.; Wallace, Eli; McCormick, Frank; Beltran, Pedro J.
err分享
err收藏
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement
errANALYTICAL CHEMISTRY
IF6.7
err2024-03-18
err2
errOAAI
errD'Ippolito, Robert A.; Rabara, Dana; Blanco, Maria Abreu; Alberico, Emily; Drew, Matthew R.; Ramakrishnan, Nitya; Sontan, Dara; Widmeyer, Stephanie R. T.; Scheidemantle, Grace M.; Messing, Simon; Turner, David; Arkin, Michelle; Maciag, Anna E.; Stephen, Andrew G.; Esposito, Dominic; Mccormick, Frank; Nissley, Dwight V.; Dehart, Caroline J.
err分享
err收藏
Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements
errCOMMUNICATIONS BIOLOGY
IF5.1
err2024-03-02
err5
errOAAI
errFinci, Lorenzo I.; Chakrabarti, Mayukh; Gulten, Gulcin; Finney, Joseph; Grose, Carissa; Fox, Tara; Yang, Renbin; Nissley, Dwight V.; McCormick, Frank; Esposito, Dominic; Balius, Trent E.; Simanshu, Dhirendra K.
err分享
err收藏

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