Karl F. Hoffmann - Publications, H-index & Citations

Karl F. Hoffmann

aberystwyth university

46H指数

170论文数

1.7W被引数

收录论文 70

发表时间

Hedera helix-derived α−hederin (IVL-11) demonstrates both ex vivo and in vivo flukicidal activities against Fasciola hepatica 常春藤属植物Hedera helix来源的α−hederin（IVL-11）在体外和体内均显示出对Fasciola hepatica的杀吸虫活性。

Biomedicine & Pharmacotherapy

IF7.5

2026-02-13

OAAI

Sarah D. Davey; Anand Chakroborty; Joseph Payne; Adam M.G. Burgess; Benjamin J. Hulme; Marc E. Bouillon; Dafydd A. Thomas; Anna Cervi; Gilda Padalino; Alan Cookson; Ayman Al-Najjar; Laura Frame; Caroline Fenn; Peter Holdsworth; Martina Lahmann; Vincent McNally; Maggie Fisher; Mark S. Baird; Karl F. Hoffmann

Novel 1H-1,2,3-Triazole Derivatives of Praziquantel with TRPMPZQ Modulatory Activity and Antiparasitic Effects on Larvae, Juvenile, and Adult Worms of Schistosoma mansoni 新型1H-1,2,3-三氮唑衍生物普raziquantel，具有TRPMPZQ调节活性和对曼氏血吸虫幼虫、幼年和成年虫的寄生虫抑制效应

ACS INFECTIOUS DISEASES

IF3.8

2025-12-01

PREAI

Junior, Floriano Paes Silva; Dantas, Rafael Ferreira; Park, Sang-Kyu; Whiteland, Helen; Oliveira, Camilla Thomaz da Silva; Rezende-Neto, Joao M.; Reis, Jordano Ferreira; Forde-Thomas, Josephine; Gomes, Luciano Pinho; Valente, Walter C. G.; Schirato, Giuliana Viegas; Noronha, Frederico Ricardo de Castro; Hoffmann, Karl F.; Marchant, Jonathan S.; Ferreira, Sabrina Baptista

Glycan remodelling of live adult Schistosoma mansoni worms by chemical inhibition of α-mannosidases☆α-甘露糖苷酶化学抑制对活体成年Schistosoma mansoni虫的糖苷重塑研究☆

International Journal for Parasitology

IF3.2

2025-11-19

PREAI

Eleonore B. Kuhlemaijer; Tom Veldhuizen; Isabella A. van Hulst; Tessa Liesker; Benjamin J. Hulme; Josephine E. Forde-Thomas; Gabriel Rinaldi; Karl F. Hoffmann; Angela van Diepen; Cornelis H. Hokke

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery P450酶在药物发现中用于晚期功能化

Journal of Medicinal Chemistry

IF6.8

2025-10-12

OAAI

Vincent Poon; Christopher Bailey; Sandra Carvalho; Stephen Patterson; James W. B. Fyfe; Olga Semenova; Stephen K. Wrigley; Emily Hopkins; Ravi Manohar; Christopher Drake; Tetsuo Kokubun; John Boyle; Lisbet Kvaerno; Kristin Lees; Karl F. Hoffmann; Josephine Forde-Thomas; Susan Wyllie; Jonathan Steele; Ian H. Gilbert; Gary J. Tarver

Anthelmintic evaluation of triterpenes derived from conifers (family Pinaceae) on the digenean parasite Fasciola hepatica 松科（Pinaceae）植物中提取的三萜类化合物的驱虫活性评价——针对吸虫寄生虫 Fasciola hepatica

Fitoterapia

IF2.6

2025-07-27

OAAI

Anand Chakroborty; Bismark Dankwa; Alessandra Crusco; Josephine E. Forde-Thomas; Shashika Abeysekara; Ziada Kiwanuka; Mia Ley; Sarah D. Davey; Jackie Hollinshead; Barbara Bartholomew; Charlotte Wild; Caroline Fenn; Dafydd A. Thomas; Peter Holdsworth; Maggie Fisher; Mark S. Baird; Robert J. Nash; Karl F. Hoffmann

Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms

MICROBIOLOGYOPEN

IF4.6

2024-12-12

OAAI

Padalino, Gilda; Duggan, Katrina; Mur, Luis A. J.; Maillard, Jean-Yves; Brancale, Andrea; Hoffmann, Karl F.

Gut microbiota and immune profiling of microbiota-humanised versus wildtype mouse models of hepatointestinal schistosomiasis 肝肠道血吸虫病的微生物群和免疫分析-人源化与野生型小鼠模型

ANIMAL MICROBIOME

IF4.4

2024-06-25

OAAI

Stark, K. A.; Rinaldi, G.; Costain, A.; Clare, S.; Tolley, C.; Almeida, A.; Mccarthy, C.; Harcourt, K.; Brandt, C.; Lawley, T. D.; Berriman, M.; Macdonald, A. S.; Forde-Thomas, J. E.; Hulme, B. J.; Hoffmann, K. F.; Cantacessi, C.; Cortes, A.

Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-12-04

OAAI

Schiedel, Matthias; McArdle, Darius J. B.; Padalino, Gilda; Chan, Anthony K. N.; Forde-Thomas, Josephine; McDonough, Michael; Whiteland, Helen; Beckmann, Manfred; Cookson, Rosa; Hoffmann, Karl F.; Conway, Stuart J.

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

PHARMACEUTICS

IF5.5

2023-07-03

OAAI

Chakroborty, Anand; Pritchard, Deiniol R. R.; Bouillon, Marc E. E.; Cervi, Anna; Kraehenbuehl, Rolf; Wild, Charlotte; Fenn, Caroline; Holdsworth, Peter; Capner, Colin; Padalino, Gilda; Forde-Thomas, Josephine E. E.; Payne, Joseph; Smith, Brendan G. G.; Fisher, Maggie; Lahmann, Martina; Baird, Mark S. S.; Hoffmann, Karl F. F.

Using ChEMBL to Complement Schistosome Drug Discovery

PHARMACEUTICS

IF5.5

2023-04-28

OAAI

Padalino, Gilda; Coghlan, Avril; Pagliuca, Giampaolo; Forde-Thomas, Josephine E.; Berriman, Matthew; Hoffmann, Karl F.

Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022

ACS INFECTIOUS DISEASES

IF3.8

2023-04-21

OAAI

Caldwell, Nicola; Afshar, Rana; Baragana, Beatriz; Bustinduy, Amaya L.; Caffrey, Conor R. .; Collins, James J.; Fusco, Daniela; Garba, Amadou; Gardner, Mark; Gomes, Mireille; Hoffmann, Karl F.; Hsieh, Michael; Lo, Nathan C.; McNamara, Case W.; Nono, Justin Komguep; Padalino, Gilda; Read, Kevin D.; Roestenberg, Meta; Spangenberg, Thomas; Specht, Sabine; Gilbert, Ian H.

Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis

NATURE COMMUNICATIONS

IF15.7

2023-04-03

OAAI

Houlder, E. L.; Costain, A. H.; Nambuya, I.; Brown, S. L.; Koopman, J. P. R.; Langenberg, M. C. C.; Janse, J. J.; Hoogerwerf, M. A.; Ridley, A. J. L.; Forde-Thomas, J. E.; Colombo, S. A. P.; Winkel, B. M. F.; Galdon, A. A.; Hoffmann, K. F.; Cook, P. C.; Roestenberg, M.; Mpairwe, H.; MacDonald, A. S.

Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility

JOURNAL OF EXTRACELLULAR VESICLES

IF14.5

2023-01-05

OAAI

White, Ruby; Sotillo, Javier; Ancarola, Maria Eugenia; Borup, Anne; Boysen, Anders Toftegaard; Brindley, Paul J.; Buzas, Edit, I; Cavallero, Serena; Chaiyadet, Sujittra; Chalmers, Iain W.; Cucher, Marcela A.; Dagenais, Maude; Davis, Chelsea N.; Devaney, Eileen; Duque-Correa, Maria A.; Eichenberger, Ramon Marc; Fontenla, Santiago; Gasan, Thomas A.; Hokke, Cornelis H.; Kosanovic, Maja; Kuipers, Marije E.; Laha, Thewarach; Loukas, Alex; Maizels, Rick M.; Marcilla, Antonio; Mazanec, Hynek; Morphew, Russell M.; Neophytou, Kyriaki; Nguyen, Linh Thuy; Nolte-'t Hoen, Esther; Povelones, Michael; Robinson, Mark W.; Rojas, Alicia; Schabussova, Irma; Smits, Hermelijn H.; Sungpradit, Sivapong; Tritten, Lucienne; Whitehead, Bradley; Zakeri, Amin; Nejsum, Peter; Buck, Amy H.; Hoffmann, Karl F.

Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production

PLOS PATHOGENS

IF4.9

2022-01-13

OAAI

Hulme, Benjamin J.; Geyer, Kathrin K.; Forde-Thomas, Josephine E.; Padalino, Gilda; Phillips, Dylan W.; Ittiprasert, Wannaporn; Karinshak, Shannon E.; Mann, Victoria H.; Chalmers, Iain W.; Brindley, Paul J.; Hokke, Cornelis H.; Hoffmann, Karl F.

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2021-12-01

OAAI

Padalino, Gilda; El-Sakkary, Nelly; Liu, Lawrence J.; Liu, Chenxi; Harte, Danielle S. G.; Barnes, Rachel E.; Sayers, Edward; Forde-Thomas, Josephine; Whiteland, Helen; Bassetto, Marcella; Ferla, Salvatore; Johnson, George; Jones, Arwyn T.; Caffrey, Conor R.; Chalmers, Iain; Brancale, Andrea; Hoffmann, Karl F.

Schistosoma mansoni Larval Extracellular Vesicle protein 1 (SmLEV1) is an immunogenic antigen found in EVs released from pre-acetabular glands of invading cercariae

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2021-11-18

OAAI

Gasan, Thomas A.; Kuipers, Marije E.; Roberts, Grisial H.; Padalino, Gilda; Forde-Thomas, Josephine E.; Wilson, Shona; Wawrzyniak, Jakub; Tukahebwa, Edridah M.; Hoffmann, Karl F.; Chalmers, Iain W.

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni

ACS INFECTIOUS DISEASES

IF3.8

2021-04-02

OAAI

Partridge, Frederick A.; Bataille, Carole J. R.; Forman, Ruth; Marriott, Amy E.; Forde-Thomas, Josephine; Haeberli, Cecile; Dinsdale, Ria L.; O'Sullivan, James D. B.; Willis, Nicky J.; Wynne, Graham M.; Whiteland, Helen; Archer, John; Steven, Andrew; Keiser, Jennifer; Turner, Joseph D.; Hoffmann, Karl F.; Taylor, Mark J.; Else, Kathryn J.; Russell, Angela J.; Sattelle, David B.

Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

IF8.5

2021-04-01

PREAI

Cardoso, Iara Aime; Luiz de Souza, Aline Kusumota; Burgess, Adam Muslem George; Chalmers, Iain Wyllie; Hoffmann, Karl Francis; Nonato, Maria Cristina

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function 曼氏血吸虫毒液过敏原样蛋白6 (SmVAL6) 维持皮肤屏障功能

INTERNATIONAL JOURNAL FOR PARASITOLOGY

IF3.2

2021-03-01

OAAI

Perally, Samirah; Geyer, Kathrin K.; Farani, Priscila S. G.; Chalmers, Iain W.; Fernandez-Fuentes, Narcis; Maskell, Daniel R.; Hulme, Benjamin J.; Forde-Thomas, Josephine; Phillips, Dylan; Farias, Leonardo P.; Collins III, James J.; Hoffmann, Karl F.

Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni

PLOS NEGLECTED TROPICAL DISEASES

IF3.4

2021-02-18

OAAI

Craven, Holly M.; Bonsignore, Riccardo; Lenis, Vasilis; Santi, Nicolo; Berrar, Daniel; Swain, Martin; Whiteland, Helen; Casini, Angela; Hoffmann, Karl F.

研究方向