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韩

韩欣 (Xin Han)

zhejiang university邮箱:xinhan@zju.edu.cn
H指数:26
被引数:2,910

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荣誉奖项

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Discovery of a First-in-Class Murine Double Minute 2-Recruiting Positive Transcription Elongation Factor B PROTAC Degrader With Selective Antitumor Activity

发现一种具有选择性抗肿瘤活性的第一类小鼠双微体2招募阳性转录延伸因子B PROTAC降解剂

MedComm
IF10.7
2026-04-090
OAAI
Xian Guan; Long Xie; Hanjun Guo; Lin Ma; Jiawei Zhou; Lisong Luo; Hao Yang; Yuanfang Wu; Jiangyu Liu; Yue Wang; Xingze Huang; Jiyang Liu; Ying Zhang; Wenhao Chen; Ye Chen; Liang Xu; Xin Han
Discovery of a Novel Potent and Orally Efficacious PGK1 Inhibitor C67–47 for the Treatment of Human Pancreatic Cancer

刘, L.; 江, X.; 赵, H.; 杨, H.; 杨, H.; 郭, D.; 罗, S.; 杨, Q.; 李, S.; 吴, L.; 等. 发现一种新型强效且口服有效的PGK1抑制剂C67-47用于治疗人胰腺癌. J. Med. Chem. 2026, 69, 12955–12972. [Google Scholar] [CrossRef] [Scilit]

Journal of Medicinal Chemistry
IF6.8
2026-01-010
PRE
Lihua Liu; Xiaoming Jiang; Hong Zhao; Hongli Yang; Hao Yang; Dong Guo; Shudi Luo; Qingqing Yang; S B Li; Lihui Wu; 聂豆; Zou Lu; Xin Han
Kill Two Birds with One Stone: An Efficient and Potent AR CBS-Targeted Degrader Reverses Breast Cancer Resistance via Concurrent AR Degradation and ERα Transcriptional Suppression

一石二鸟：一种高效且强效的AR CBS靶向降解剂通过同时降解AR和抑制ERα转录来逆转乳腺癌耐药性

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-11-010
PRE
Wu, Yihe; Xie, Baohua; Liang, Jinsen; Wei, Dongmei; Wang, Yubo; Yin, Yudong; Deng, Xiaofei; Wang, Chao; Ni, Jian; Yang, Lanxin; Dong, Chune; Han, Xin; Zhou, Hai-Bing
Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-0818
OA
Xiang, Weiguo; Zhao, Lijie; Han, Xin; Xu, Tianfeng; Kregel, Steven; Wang, Mi; Miao, Bukeyan; Qin, Chong; Wang, Mingliang; McEachern, Donna; Lu, Jianfeng; Bai, Longchuan; Yang, Chao-Yie; Kirchhoff, Paul D.; Takyi-Williams, John; Wang, Lu; Wen, Bo; Sun, Duxin; Ator, Mark; Mckean, Robert; Chinnaiyan, Arul M.; Wang, Shaomeng
Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-06-2919
PRE
Han, Xin; Zhao, Lijie; Xiang, Weiguo; Miao, Bukeyan; Qin, Chong; Wang, Mi; Xu, Tianfeng; McEachern, Donna; Lu, Jianfeng; Wang, Yu; Metwally, Hoda; Yang, Chao-Yie; Kirchhoff, Paul D. D.; Wang, Lu; Matvekas, Aleksas; Takyi-Williams, John; Wen, Bo; Sun, Duxin; Ator, Mark; Mckean, Robert; Wang, Shaomeng

研究方向

CRL-E3连接酶-泛素化/拟素化通路小分子抑制剂的研发基于PROTAC技术的靶向蛋白降解剂药物的设计合成及临床前成药性评价。 ·围绕克服肿瘤耐药这一重大临床需求，开展抗癌新药的分子设计合成与开发工作，并实现临床转化
Shaomeng Wang 封面图
Shaomeng Wang
H 指数:101论文数:1,004被引数:4.0万
L
Lijie Zhao
H 指数:19论文数:45被引数:1,659
秦冲 封面图
秦冲
H 指数:27论文数:85被引数:3,382
W
Weiguo Xiang
H 指数:10论文数:48被引数:1,458
M
Mi Wang
H 指数:42论文数:348被引数:8,351
D
Donna McEachern
H 指数:42论文数:175被引数:7,485
B
Bukeyan Miao
H 指数:18论文数:43被引数:1,539
C
Chune Dong
H 指数:29论文数:137被引数:2,209
C
Chao‐Yie Yang
H 指数:49论文数:170被引数:9,942
E
Ester Fernández‐Salas
H 指数:25论文数:91被引数:3,223