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M

Martin Egli

vanderbilt university

71H指数
514论文数
1.5W被引数
收录论文 170
发表时间
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Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency无环丝氨醇核酸修饰的siRNAs克服了种子区域介导的脱靶效应并保持效力
errNucleic Acids Research
IF13.1
err2026-04-17
err0
errOAAI
errTyler Chickering; Joel M Harp; Yongfeng Jiang; June Qin; Guo He; Sarah Hyde; Audrey Ihlefeld; Maja Janas; Derek K O’Flaherty; Sally Schofield; John Szeto; Christopher S Theile; Klaus Charissé; Vasant Jadhav; Martin A Maier; Muthiah Manoharan; Martin Egli; Mark K Schlegel
err分享
err收藏
Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity含环戊烷构型的核糖核酸干扰活性中碳环核苷酸的合成及其作用
errrsc chem. biol.
IF0
err2026-04-05
err0
errOAAI
errJayanta Kundu; Dhrubajyoti Datta; Masaaki Akabane-Nakata; Soham Mandal; Monika Krampert; Martin Egli; Muthiah Manoharan
err分享
err收藏
New targets and procedures for validating the valence geometry of nucleic acid structures核酸结构价键几何验证的新靶点与程序
errNucleic Acids Research
IF13.1
err2026-01-13
err1
PREAI
errCerny, Jiri; Nicholls, Robert A.; Brzezinski, Dariusz; Berman, Helen M.; Gilski, Miroslaw; Joosten, Robbie P.; Kowiel, Marcin; Lawson, Catherine L.; Moriarty, Nigel W.; Richardson, Jane S.; Schneider, Bohdan; Vonrhein, Clemens; Williams, Christopher J.; Jaskolski, Mariusz; Egli, Martin
err分享
err收藏
Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches利用正交体外和体内方法评估靶向癌基因的siRNA的突变特异性方案
errSTAR Protocols
IF1.3
err2026-01-01
err0
errOAAI
errStanland, Lyla J.; Porrello, Alessandro; Egli, Martin; Pecot, Chad V.
err分享
err收藏
A metal ion-dependent mechanism promoting gain of function in NEIL1 variants金属离子依赖性机制促进NEIL1变体的功能获得
errInternational Journal of Radiation Biology
IF2.4
err2026-01-01
err0
PREAI
errZuckerman, Jamie T.; Minko, Irina G.; Lybrand, Terry P.; Egli, Martin; McCullough, Amanda K.; Lloyd, R. Stephen
err分享
err收藏
Synthesis and Biophysical Properties of 3′-Deoxy-β-d-apio-d-furanosyl Nucleic Acids3′-脱氧-β-d-苹果糖基核酸的合成与生物物理性质
errACS Chemical Biology
IF3.8
err2025-10-23
err0
PREAI
errVictorio Jauregui-Matos; Dhrubajyoti Datta; Jayanta Kundu; Vathan Kumar; Joel M. Harp; Adekunle Adebayo; Daniel Donnelly; Esau Medina; John C. Chaput; Martin Egli; Muthiah Manoharan
err分享
err收藏
Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs改性未锁定核酸（MUNA）可减轻小干扰RNA的脱靶效应
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-10-14
err0
errOAAI
errMori, Shohei; Datta, Dhrubajyoti; Perkins, Lydia; Jung, Michelle; Woods, Lauren Blair; Eaton, Alex; Qin, June; Racie, Tim; Kim, MaryBeth; Guenther, Dale C.; Castoreno, Adam; Schlegel, Mark K.; Charisse, Klaus; Egli, Martin; Matsuda, Shigeo; Manoharan, Muthiah
err分享
err收藏
Inverted chimeric RNAi molecules synergistically cotarget MYC and KRAS in KRAS-driven cancers反向嵌合RNAi分子协同共靶向KRAS驱动型癌症中的MYC和KRAS
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-10-01
err1
errOAAI
errChareddy, Yogitha S.; Huggins, Hayden P.; Sahoo, Snehasudha S.; Stanland, Lyla J.; Gutierrez-Ford, Christina; Whately, Kristina M.; Edatt, Lincy; Azam, Salma H.; Fleming, Matthew C.; Im, Jonah; Porrello, Alessandro; Simmons, Imani; Perry, Jillian L.; Bowers, Albert A.; Egli, Martin; Pecot, Chad, V
err分享
err收藏
A first-in-class EGFR-directed KRAS G12V selective inhibitor一类首创的EGFR靶向KRAS G12V选择性抑制剂
errCancer Cell
IF44.5
err2025-06-19
err0
errOAAI
errLyla J. Stanland; Hayden P. Huggins; Snehasudha S. Sahoo; Alessandro Porrello; Yogitha Chareddy; Salma H. Azam; Jillian L. Perry; Pradeep S. Pallan; Kristina Whately; Lincy Edatt; William D. Green; Matthew C. Fleming; Jonah Im; Christina Gutierrez-Ford; Imani Simmons; Alyaa Dawoud; Katherine I. Zhou; Vandanaa Jayaprakash; Rani S. Sellers; Gabriela de la Cruz; Albert Wielgus; Justin Milner; Martin Egli; Albert A. Bowers; Chad V. Pecot
err分享
err收藏
Modulation of TTR gene expression in the eye using modified siRNAs使用修饰的siRNAs调节眼中TTR基因的表达
errNUCLEIC ACIDS RESEARCH
IF13.1
err2025-05-19
err0
errOAAI
errHu, Jiaxin; Gong, Xin; Kundu, Jayanta; Datta, Dhrubajyoti; Egli, Martin; Manoharan, Muthiah; Mootha, V. Vinod; Corey, David R.
err分享
err收藏
Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6′-vinylphosphonate at the 5′ end of the antisense strand improves RNAi activity
errCHEMICAL COMMUNICATIONS
IF4.2
err2025-04-01
err0
PREAI
errDatta, Dhrubajyoti; Kundu, Jayanta; Miller, Patrick; Khan, Mehreen S.; Salinas, Juan; Qin, June; Leblanc, Sarah; Nguyen, Tuyen; Peng, Haiyan; Theile, Christopher S.; Egli, Martin; Manoharan, Muthiah
err分享
err收藏
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain扩展RNAi疗法共轭空间：反义链3′端的配体实现了无妥协的在体效价和疗效，并揭示了与Argonaute-2 PAZ结构域的相互作用
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-02-03
err2
PREAI
errDas, Rajat S.; Datta, Dhrubajyoti; Brown, Christopher R.; Gilbert, Jason A.; Chan, Amy; Willoughby, Jennifer; Gupta, Swati; Kim, Marybeth; Degaonkar, Rohan; Racie, Tim; Lei, Li; Schlegel, Mark K.; Castoreno, Adam; Charisse, Klaus; Rajeev, Kallanthottathil G.; Egli, Martin; Manoharan, Muthiah
err分享
err收藏
A first-in-class EGFR-directed KRAS G12V selective inhibitor
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-11-14
err0
PREAI
errStanland, Lyla; Huggins, Hayden; Porrello, Alessandro; Chareddy, Yogitha; Azam, Salma; Perry, Jillian; Pallan, Pradeep; Whately, Kristina; Edatt, Lincy; Fleming, Matthew; Im, Jonah; Gutierrez-Ford, Christina; Simmons, Imani; Jayaprakash, Vandanaa; Sellers, Rani; de la Cruz, Gabriela; Wielgus, Albert; Egli, Martin; Bowers, Albert; Pecot, Chad
err分享
err收藏
Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications
errORGANIC LETTERS
IF5
err2024-11-11
err1
errOAAI
errDatta, Dhrubajyoti; Kumar, Pawan; Kundu, Jayanta; Qin, June; Gilbert, Jason A.; Schofield, Sally; Donnelly, Daniel P.; Liu, Ju; Degaonkar, Rohan; Egli, Martin; Manoharan, Muthiah
err分享
err收藏
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-10-07
err0
PREAI
errAluri, Krishna C.; Datta, Dhrubajyoti; Waldron, Scott; Taneja, Nate; Qin, June; Donnelly, Daniel P.; Theile, Christopher S.; Guenther, Dale C.; Lei, Li; Harp, Joel M.; Pallan, Pradeep S.; Egli, Martin; Zlatev, Ivan; Manoharan, Muthiah
err分享
err收藏
Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-02-20
err0
errOAAI
errHumboldt, Adrian; Rami, Fabian; Topp, Franka M.; Arnold, Dejana; Goehringer, Daniela; Pallan, Pradeep S.; Egli, Martin; Richert, Clemens
err分享
err收藏
Conformation matters: siRNAs with antisense strands with 5′-(E)-vinyl-phosphonate-α-L-LNA elicit stronger RNAi-mediated gene silencing than those with 5′-(E)-vinyl-phosphonate-LNA
errCHEMICAL COMMUNICATIONS
IF4.2
err2024-01-01
err0
PREAI
errDatta, Dhrubajyoti; Kumar, Pawan; Mandal, Soham; Krampert, Monika; Egli, Martin; Hrdlicka, Patrick J.; Manoharan, Muthiah
err分享
err收藏
Synthesis and Biophysical Studies of High-Affinity Morpholino Oligomers Containing G-Clamp Analogs
errJOURNAL OF ORGANIC CHEMISTRY
IF3.6
err2023-10-16
err3
PREAI
errDas, Arnab; Ghosh, Atanu; Kundu, Jayanta; Egli, Martin; Manoharan, Muthiah; Sinha, Surajit
err分享
err收藏
Robert Letsinger and the Evolution of Oligonucleotide Synthesis
errACS OMEGA
IF4.3
err2023-09-01
err0
errOAAI
errEgli, Martin
err分享
err收藏
Shorter Is Better: The a-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-08-28
err12
PREAI
errMatsuda, Shigeo; Bala, Saikat; Liao, Jen-Yu; Datta, Dhrubajyoti; Mikami, Atsushi; Woods, Lauren; Harp, Joel M.; Gilbert, Jason A.; Bisbe, Anna; Manoharan, Rajar M.; Kim, MaryBeth; Theile, Christopher S.; Guenther, Dale C.; Jiang, Yongfeng; Agarwal, Saket; Maganti, Rajanikanth; Schlegel, Mark K.; Zlatev, Ivan; Charisse, Klaus; Rajeev, Kallanthottathil G.; Castoreno, Adam; Egli, Martin; Janas, Maja M.; Egli, Martin; Chaput, John C.; Manoharan, Muthiah
err分享
err收藏

研究方向

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