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Modified unlocked nucleic acid (MUNA) mitigates off-target effects of small interfering RNAs 改性未锁定核酸（MUNA）可减轻小干扰RNA的脱靶效应 Mori, Shohei; Datta, Dhrubajyoti; Perkins, Lydia; Jung, Michelle; Woods, Lauren Blair; Eaton, Alex; Qin, June; Racie, Tim; Kim, MaryBeth; Guenther, Dale C.; Castoreno, Adam; Schlegel, Mark K.; Charisse, Klaus; Egli, Martin; Matsuda, Shigeo; Manoharan, Muthiah 分享 收藏
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Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6′-vinylphosphonate at the 5′ end of the antisense strand improves RNAi activity Datta, Dhrubajyoti; Kundu, Jayanta; Miller, Patrick; Khan, Mehreen S.; Salinas, Juan; Qin, June; Leblanc, Sarah; Nguyen, Tuyen; Peng, Haiyan; Theile, Christopher S.; Egli, Martin; Manoharan, Muthiah 分享 收藏
Expanding Conjugate Space of RNAi Therapeutics: Ligand at the 3′ End of the Antisense Strand Achieves Uncompromised In Vivo Potency and Efficacy and Reveals Interactions with the Argonaute-2 PAZ Domain 扩展RNAi疗法共轭空间：反义链3′端的配体实现了无妥协的在体效价和疗效，并揭示了与Argonaute-2 PAZ结构域的相互作用 Das, Rajat S.; Datta, Dhrubajyoti; Brown, Christopher R.; Gilbert, Jason A.; Chan, Amy; Willoughby, Jennifer; Gupta, Swati; Kim, Marybeth; Degaonkar, Rohan; Racie, Tim; Lei, Li; Schlegel, Mark K.; Castoreno, Adam; Charisse, Klaus; Rajeev, Kallanthottathil G.; Egli, Martin; Manoharan, Muthiah 分享 收藏
Improved In Vivo Metabolic Stability and Silencing Efficacy of siRNAs with Phosphorothioate Linkage-Free, GalNAc-Conjugated Sense Strands Containing Morpholino-LNA Modifications Datta, Dhrubajyoti; Kumar, Pawan; Kundu, Jayanta; Qin, June; Gilbert, Jason A.; Schofield, Sally; Donnelly, Daniel P.; Liu, Ju; Degaonkar, Rohan; Egli, Martin; Manoharan, Muthiah 分享 收藏
Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway Aluri, Krishna C.; Datta, Dhrubajyoti; Waldron, Scott; Taneja, Nate; Qin, June; Donnelly, Daniel P.; Theile, Christopher S.; Guenther, Dale C.; Lei, Li; Harp, Joel M.; Pallan, Pradeep S.; Egli, Martin; Zlatev, Ivan; Manoharan, Muthiah 分享 收藏
Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates Yu, Mikyung; Qin, June; Liu, Xiumin; Ramsden, Diane; Williams, Brian; Zlatev, Ivan; Guenther, Dale; Matsuda, Shigeo; Tymon, Roxanne; Darcy, Justin; Wong, Catrina; Tsung, Jamie; Zawaneh, Peter; Chong, Saeho; Theile, Christopher S.; Taneja, Nathan; Rogers, Arlin; Liu, Ju; Castellanos-Rizaldos, Elena; Bond, Sarah; So, Kawai; Denoncourt, Jason; Castoreno, Adam; Manoharan, Muthiah; Wu, Jing-Tao; Fitzgerald, Kevin; Maier, Martin A.; Jadhav, Vasant; Nair, Jayaprakash K. 分享 收藏
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Shorter Is Better: The a-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs Matsuda, Shigeo; Bala, Saikat; Liao, Jen-Yu; Datta, Dhrubajyoti; Mikami, Atsushi; Woods, Lauren; Harp, Joel M.; Gilbert, Jason A.; Bisbe, Anna; Manoharan, Rajar M.; Kim, MaryBeth; Theile, Christopher S.; Guenther, Dale C.; Jiang, Yongfeng; Agarwal, Saket; Maganti, Rajanikanth; Schlegel, Mark K.; Zlatev, Ivan; Charisse, Klaus; Rajeev, Kallanthottathil G.; Castoreno, Adam; Egli, Martin; Janas, Maja M.; Egli, Martin; Chaput, John C.; Manoharan, Muthiah 分享 收藏
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Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways Kandasamy, Pachamuthu; Mori, Shohei; Matsuda, Shigeo; Erande, Namrata; Datta, Dhrubajyoti; Willoughby, Jennifer L. S.; Taneja, Nate; O'Shea, Jonathan; Bisbe, Anna; Manoharan, Rajar M.; Yucius, Kristina; Nguyen, Tuyen; Indrakanti, Ramesh; Gupta, Swati; Gilbert, Jason A.; Racie, Tim; Chan, Amy; Liu, Ju; Hutabarat, Renta; Nair, Jayaprakash K.; Charisse, Klaus; Maier, Martin A.; Rajeev, Kallanthottathil G.; Egli, Martin; Manoharan, Muthiah 分享 收藏
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