Nobutaka Hirokawa - Publications, H-index & Citations

Nobutaka Hirokawa

the university of tokyo

115H指数

4.0K论文数

5.5W被引数

收录论文 106

发表时间

The hook-like adaptor and cargo-binding (HAC) domain in the kinesin-2 tail enables adaptor assembly and cargo recognition 动力蛋白-2尾部中的钩状适配器和货物结合（HAC）结构域能够实现适配器组装和货物识别。

Science Advances

IF12.5

2025-10-24

PREAI

Xuguang Jiang; Radostin Danev; Sotaro Ichinose; Baichun Niu; Sumio Ohtsuki; Haruaki Yanagisawa; Satoru Nagatoishi; Kouhei Tsumoto; Nobutaka Hirokawa; Masahide Kikkawa

Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover 动力蛋白KIF12的突变通过破坏脂质生成酶的周转，在人类和小鼠中促进MASH的发生。

EMBO JOURNAL

IF8.3

2025-02-07

OAAI

Etemad, Asieh; Tanaka, Yosuke; Wang, Shuo; Slae, Mordechai; Sultan, Mutaz; Elpeleg, Orly; Hirokawa, Nobutaka

Kinesin-1 mediates proper ER folding of the CaV1.2 channel and maintains mouse glucose homeostasis

EMBO REPORTS

IF6.2

2024-09-25

OAAI

Tanaka, Yosuke; Farkhondeh, Atena; Yang, Wenxing; Ueno, Hitoshi; Noda, Mitsuhiko; Hirokawa, Nobutaka

The two-step cargo recognition mechanism of heterotrimeric kinesin

EMBO REPORTS

IF6.2

2023-08-14

OAAI

Jiang, Xuguang; Ogawa, Tadayuki; Yonezawa, Kento; Shimizu, Nobutaka; Ichinose, Sotaro; Uchihashi, Takayuki; Nagaike, Wataru; Moriya, Toshio; Adachi, Naruhiko; Kawasaki, Masato; Dohmae, Naoshi; Senda, Toshiya; Hirokawa, Nobutaka

Nodal flow transfers polycystin to determine mouse left-right asymmetry

DEVELOPMENTAL CELL

IF8.7

2023-08-01

OAAI

Tanaka, Yosuke; Morozumi, Ai; Hirokawa, Nobutaka

Molecular motor KIF1C is not essential for mouse survival and motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Nakajima, K; Takei, Y; Tanaka, Y; Nakagawa, T; Nakata, T; Noda, Y; Setou, M; Hirokawa, N

KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway

JOURNAL OF CELL BIOLOGY

IF6.4

2022-12-08

PREAI

Wan, Yuansong; Morikawa, Momo; Morikawa, Manatsu; Iwata, Suguru; Naseer, Muhammad Imran; Chaudhary, Adeel Gulzar Ahmed; Tanaka, Yosuke; Hirokawa, Nobutaka

KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

DEVELOPMENTAL CELL

IF8.7

2022-10-01

OAAI

Wang, Shuo; Tanaka, Yosuke; Xu, Ying; Takeda, Sen; Hirokawa, Nobutaka

A neuropathy-associated kinesin KIF1A mutation hyper-stabilizes the motor-neck interaction during the ATPase cycle

EMBO JOURNAL

IF8.3

2022-02-08

OAAI

Morikawa, Manatsu; Jerath, Nivedita U.; Ogawa, Tadayuki; Morikawa, Momo; Tanaka, Yosuke; Shy, Michael E.; Zuchner, Stephan; Hirokawa, Nobutaka

Betaine ameliorates schizophrenic traits by functionally compensating for KIF3-based CRMP2 transport

CELL REPORTS

IF6.9

2021-04-01

OAAI

Yoshihara, Shogo; Jiang, Xuguang; Morikawa, Momo; Ogawa, Tadayuki; Ichinose, Sotaro; Yabe, Hirooki; Kakita, Akiyoshi; Toyoshima, Manabu; Kunii, Yasuto; Yoshikawa, Takeo; Tanaka, Yosuke; Hirokawa, Nobutaka

An activity-dependent local transport regulation via degradation and synthesis of KIF17 underlying cognitive flexibility

SCIENCE ADVANCES

IF12.5

2020-12-18

OAAI

Iwata, Suguru; Morikawa, Momo; Takei, Yosuke; Hirokawa, Nobutaka

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice

EMBO JOURNAL

IF8.3

2019-11-20

OAAI

Alsabban, Ashwaq Hassan; Morikawa, Momo; Tanaka, Yosuke; Takei, Yosuke; Hirokawa, Nobutaka

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

EMBO MOLECULAR MEDICINE

IF8.3

2019-10-28

OAAI

Ide, Masayuki; Ohnishi, Tetsuo; Toyoshima, Manabu; Balan, Shabeesh; Maekawa, Motoko; Shimamoto-Mitsuyama, Chie; Iwayama, Yoshimi; Ohba, Hisako; Watanabe, Akiko; Ishii, Takashi; Shibuya, Norihiro; Kimura, Yuka; Hisano, Yasuko; Murata, Yui; Hara, Tomonori; Morikawa, Momo; Hashimoto, Kenji; Nozaki, Yayoi; Toyota, Tomoko; Wada, Yuina; Tanaka, Yosuke; Kato, Tadafumi; Nishi, Akinori; Fujisawa, Shigeyoshi; Okano, Hideyuki; Itokawa, Masanari; Hirokawa, Nobutaka; Kunii, Yasuto; Kakita, Akiyoshi; Yabe, Hirooki; Iwamoto, Kazuya; Meno, Kohji; Katagiri, Takuya; Dean, Brian; Uchida, Kazuhiko; Kimura, Hideo; Yoshikawa, Takeo

Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

LIFE SCIENCE ALLIANCE

IF2.9

2019-10-07

OAAI

Toyoshima, Manabu; Jiang, Xuguang; Ogawa, Tadayuki; Ohnishi, Tetsuo; Yoshihara, Shogo; Balan, Shabeesh; Yoshikawa, Takeo; Hirokawa, Nobutaka

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

CELL REPORTS

IF6.9

2019-10-01

389

OAAI

Maekawa, Hiroshi; Inoue, Tsuyoshi; Ouchi, Haruki; Jao, Tzu-Ming; Inoue, Reiko; Nishi, Hiroshi; Fujii, Rie; Ishidate, Fumiyoshi; Tanaka, Tetsuhiro; Tanaka, Yosuke; Hirokawa, Nobutaka; Nangaku, Masaomi; Inagi, Reiko

The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling

CELL REPORTS

IF6.9

2019-08-01

OAAI

Ichinose, Sotaro; Ogawa, Tadayuki; Jiang, Xuguang; Hirokawa, Nobutaka

Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport

JOURNAL OF CELL BIOLOGY

IF6.4

2018-10-08

OAAI

Shima, Tomohiro; Morikawa, Manatsu; Kaneshiro, Junichi; Kambara, Taketoshi; Kamimura, Shinji; Yagi, Toshiki; Iwamoto, Hiroyuki; Uemura, Sotaro; Shigematsu, Hideki; Shirouzu, Mikako; Ichimura, Taro; Watanabe, Tomonobu M.; Nitta, Ryo; Okada, Yasushi; Hirokawa, Nobutaka

The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase

CELL REPORTS

IF6.9

2018-09-01

OAAI

Wang, Li; Tanaka, Yosuke; Wang, Doudou; Morikawa, Momo; Zhou, Ruyun; Homma, Noriko; Miyamoto, Yuki; Hirokawa, Nobutaka

KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth

JOURNAL OF CELL BIOLOGY

IF6.4

2018-08-20

OAAI

Xu, Fang; Takahashi, Hironori; Tanaka, Yosuke; Ichinose, Sotaro; Niwa, Shinsuke; Wicklund, Matthew P.; Hirokawa, Nobutaka