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G

G.J. Lockbaum

University of Massachusetts Chan Medical School
H指数:16
被引数:731

个人简介

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教育背景

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工作经历

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荣誉奖项

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Fluorinated HIV-1 Protease Inhibitors Containing Chiral Hydroxyethylbenzene and Indanol as P2′ Ligands with Potent Activity Against Drug-Resistant Variants

含手性羟乙基苯和吲哚醇作为P2′配体的氟化HIV-1蛋白酶抑制剂，对耐药变异体具有显著活性

European Journal of Medicinal Chemistry
IF5.9
2025-12-190
PRE
Jagroop Kaur; Ean Spielvogel; Desaboini Nageswara Rao; Linah N. Rusere; Ala M. Shaqra; Gordon J. Lockbaum; Arooma Maryam; Nese Kurt Yilmaz; Ronald Swanstrom; Celia A. Schiffer; Akbar Ali
Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

ATX020丝兰蛋白KIF18A抑制剂的发现：硅原子替换的战术应用

ACS Medicinal Chemistry Letters
IF4
2025-10-270
PRE
Brian A. Sparling; Hyelee Lee; Mary-Margaret Zablocki; Maureen M. Lynes; Simina Grigoriu; Livia Shehaj; Gordon J. Lockbaum; Sanjoy K. Khan; Taylor Hotz; Young-Tae Lee; Shane M. Buker; Deepali Gotur; Chuang Lu; Scott Ribich; Stephen J. Blakemore; P. Ann Boriack-Sjodin; Serena J. Silver; Robert A. Copeland; Kenneth W. Duncan
Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968的发现：一种可口服的DHX9别构抑制剂

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-290
OA
Daniels, Matthew H.; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E.; Grigoriu, Simina; Lockbaum, Gordon J.; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M.; Liu, Julie; Yao, Shihua; Sparling, Brian A.; Sickmier, E. Allen; Ribich, Scott; Blakemore, Steve J.; Silver, Serena J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Copeland, Robert A.
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor

外切核糖核酸酶XRN1作为癌症靶点的表征及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

COMMUNICATIONS BIOLOGY
IF5.1
2025-04-090
OA
Lockbaum, Gordon J.; Lynes, Maureen M.; Shen, Sophie A.; Liu, Julie; Holt, Nicholas; Nayak, Sunaina P.; Knockenhauer, Kevin E.; Yao, Shihua; Sickmier, E. Allen; Raman, Anugraha; Wu, Jie; Case, April; Shehaj, Livia; Buker, Shane M.; Grigoriu, Simina; Ribich, Scott; Blakemore, Stephen J.; Sparling, Brian A.; Duncan, Kenneth W.; Copeland, Robert A.; Silver, Serena J.; Boriack-Sjodin, P. Ann
RNA-modifying enzyme inhibitors as synthetic lethal cancer therapeutics
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Silver, Serena J.; Lynes, Maureen M.; Sparling, Brian A.; Castro, Jennifer; Daniels, Matthew H.; Pai, Sunaina; Shen, Sophie A.; Brennan, David; Lee, Hyelee; Lockbaum, Gordon J.; Knockenhauer, Kevin; Gotur, Deepali; Grigoriu, Simina; Yao, Shihua; Buker, Shane; Laidlaw, Monique; Wu, Jie; Blakemore, Stephen J.; Boriack-Sjodin, P. Ann; Duncan, Kenneth W.; Sager, Jason A.; Copeland, Robert A.
Discovery of small molecule inhibitors of ADAR1
MOLECULAR CANCER THERAPEUTICS
IF5.5
2023-12-011
PRE
Buker, Shane M.; Blakemore, Stephen J.; Boriack-Sjodin, P. Ann; Collins, Cindy; Copeland, Robert A.; Duncan, Kenneth W.; Ericsson, Anna; Garadino, Alexandra; Greene-Colozzi, April; Leger, Nathalie; Lockbaum, Gordon; Raman, Anugraha; Ribich, Scott; Sickmier, Allen; Sparling, Brian S.; Wu, Jie; Silver, Serena

研究方向

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C
Celia A. Schiffer
H 指数:64论文数:422被引数:1.1万
N
Neşe Kurt Yılmaz
H 指数:31论文数:137被引数:3,336
A
Akbar Ali
H 指数:30论文数:78被引数:3,394
M
M. Henes
H 指数:13论文数:49被引数:421
E
E.A. Nalivaika
H 指数:26论文数:84被引数:2,758
L
L.N. Rusere
H 指数:11论文数:36被引数:410
K
K. Kosovrasti
H 指数:11论文数:50被引数:273
R
Robert A. Copeland
H 指数:54论文数:438被引数:1.8万
K
Kenneth W. Duncan
H 指数:10论文数:61被引数:1,245
P
P. Ann Boriack‐Sjodin
H 指数:32论文数:135被引数:4,907