未登录 分享 收藏
分享 收藏
Template-driven scaffolding of SCFFBXO42 regulates PP2A degradation 模板驱动的SCFFBXO42支架调节PP2A降解 Coassolo, Sebastien; Michaelian, Nairie; Maculins, Timurs; Azumaya, Caleigh M.; Cheung, Tommy K.; Yin, Jianping; Zilberleyb, Inna; Pahuja, Kanika Bajaj; Garner, Thomas; Lau, Ted; Mau, Davis; Grimmer, Matthew; Fortin, Jean-Philippe; Costa, Mike; Dimitrova, Yoana N.; Rose, Christopher M.; Hsu, Peter L.; Yauch, Robert L. 分享 收藏
分享 收藏
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models (vol 67, pg 1262, 2024) PROTACs靶向BRM（SMARCA2）可在体内实现对BRG1（SMARCA4）的选择性降解，并在BRG1突变异种移植肿瘤模型中表现出活性（vol 67, pg 1262, 2024） Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Crew, Andrew P.; Davenport, Kim; Dinicola, Dean; Dong, Hanqing; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Snyder, Lawrence B.; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Gan; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S. 分享 收藏
Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs Zhang, Donglu; Ma, Bin; Dragovich, Peter S.; Ma, Li; Chen, Shu; Chen, Eugene C.; Ye, Xiaofen; Liu, Joyce; Pizzano, Jennifer; Bortolon, Elizabeth; Chan, Emily; Zhang, Xing; Chen, Yi-Chen; Levy, Elizabeth S.; Yauch, Robert L.; Khojasteh, S. Cyrus; Hop, Cornelis E. C. A. 分享 收藏
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models Berlin, Michael; Cantley, Jennifer; Bookbinder, Mark; Bortolon, Elizabeth; Broccatelli, Fabio; Cadelina, Greg; Chan, Emily W.; Chen, Huifen; Chen, Xin; Cheng, Yunxing; Cheung, Tommy K.; Davenport, Kim; DiNicola, Dean; Gordon, Debbie; Hamman, Brian D.; Harbin, Alicia; Haskell, Roy; He, Mingtao; Hole, Alison J.; Januario, Thomas; Kerry, Philip S.; Koenig, Stefan G.; Li, Limei; Merchant, Mark; Perez-Dorado, Inmaculada; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Soto, Leofal; Staben, Leanna R.; Sun, Hongming; Tian, Qingping; Wang, Jing; Wang, Weifeng; Ye, Crystal S.; Ye, Xiaofen; Zhang, Penghong; Zhou, Yuhui; Yauch, Robert; Dragovich, Peter S. 分享 收藏
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats Maher, Jonathan; Stagg, Nicola; Cain, Gary; Andaya, Roxanne; Katavolos, Paula; Gallardo-Chang, Fermin; Pham, Anna; Ye, Xiaofen; Januario, Tom; Alcantar, Tuija; Caothien, Roger; Roose-Girma, Merone; Zhang, Donglu; Li, Ruina; Chen, Shu; Yauch, Robert L. 分享 收藏
PBRM1-deficient PBAF complexes target aberrant genomic loci to activate the NF-κB pathway in clear cell renal cell carcinoma PBRM1-deficient PBAF复合物靶向异常基因组位点以激活透明细胞肾细胞癌中的nf-κb途径 Yao, Xiaosai; Hong, Jing Han; Nargund, Amrita M.; Ng, Michelle Shu Wen; Heng, Hong Lee; Li, Zhimei; Guan, Peiyong; Sugiura, Masahiro; Chu, Pek Lim; Wang, Loo Chien; Ye, Xiaofen; Qu, James; Kwek, Xiu Yi; Lim, Jeffrey Chun Tatt; Ooi, Wen Fong; Koh, Joanna; Wang, Zhenxun; Pan, You-Fu; Ong, Yan Shan; Tan, Kiat-Yi; Goh, Jian Yuan; Ng, Sheng Rong; Pignata, Luca; Huang, Dachuan; Lezhava, Alexander; Tay, Su Ting; Lee, Minghui; Yeo, Xun Hui; Tam, Wai Leong; Rha, Sun Young; Li, Shang; Guccione, Ernesto; Futreal, Andrew; Tan, Jing; Yeong, Joe Poh Sheng; Hong, Wanjin; Yauch, Robert; Chang, Kenneth Tou-En; Sobota, Radoslaw M.; Tan, Patrick; Teh, Bin Tean 分享 收藏
PBRM1-deficient PBAF complexes target de novo genomic loci to activate NF-κB pathway in clear cell renal cell carcinoma Yao, Xiaosai; Hong, Jing Han; Nargund, Amrita; Ng, Michelle Shu Wen; Heng, Hong Lee; Li, Zhimei; Guan, Peiyong; Sugiura, Masahiro; Chu, Pek Lim; Wang, Loo Chien; Ye, Xiaofen; Yauch, Robert; Chang, Kenneth Tou-En; Sobota, Radoslaw M.; Tan, Patrick; Teh, Bin Tean 分享 收藏
Exploratory analysis of hormone receptor-positive (HR plus ), human epidermal growth factor receptor 2-negative (HER-2) PIK3CA mutated (mut) advanced breast cancer (aBC) treated with taselisib (TAS) and/or fulvestrant (FUL) reveals increased CCNE2 expression with poor outcome to placebo (PBO) plus FUL but not TAS plus FUL in SANDPIPER Johnson, Radia M.; Liu, Bonnie; Cortes, Javier; Dent, Susan; Harbeck, Nadia; Krop, Ian E.; Jacot, William; Yauch, Robert L.; Stout, Thomas J.; Schimmoller, Frauke; Gendreau, Steven; Wilson, Timothy R. 分享 收藏
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers Cantley, Jennifer; Ye, Xiaofen; Rousseau, Emma; Januario, Tom; Hamman, Brian D.; Rose, Christopher M.; Cheung, Tommy K.; Hinkle, Trent; Soto, Leofal; Quinn, Connor; Harbin, Alicia; Bortolon, Elizabeth; Chen, Xin; Haskell, Roy; Lin, Eva; Yu, Shang-Fan; Del Rosario, Geoff; Chan, Emily; Dunlap, Debra; Koeppen, Hartmut; Martin, Scott; Merchant, Mark; Grimmer, Matt; Broccatelli, Fabio; Wang, Jing; Pizzano, Jennifer; Dragovich, Peter S.; Berlin, Michael; Yauch, Robert L. 分享 收藏
Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients Fernando, Tharu M.; Piskol, Robert; Bainer, Russell; Sokol, Ethan S.; Trabucco, Sally E.; Zhang, Qing; Trinh, Huong; Maund, Sophia; Kschonsak, Marc; Chaudhuri, Subhra; Modrusan, Zora; Januario, Thomas; Yauch, Robert L. 分享 收藏
Characterization and therapeutic implications of SMARCA4 mutations in cancer Fernando, Tharu M.; Piskol, Robert; Bainer, Russell; Sokol, Ethan; Trabucco, Sally; Zhang, Qing; Huong Trinh; Maund, Sophia; Kschonsak, Marc; Chaudhuri, Subhra; Januario, Tom; Modrusan, Zora; Yauch, Robert L. 分享 收藏
Selective, chemically-induced degradation of BRM (SMARCA2) enables in vivo efficacy in BRG1 (SMARCA4)-deficient xenograft tumor models Berlin, Michael; Cantley, Jennifer; Wang, Jing; Bookbinder, Mark; Cadelina, Gregory; Chan, Emily; Chen, Huifen; Chen, Xin; Davenport, Kim; Fernando, Tharu; Gordon, Debbie; Hamman, Brian; Haskell, Roy; Ishchenko, Alexey; Kirkpatrick, Donald S.; Maher, Jonathan; Merchant, Mark; Moffat, John; Morgan, Alicia; Nguyen, An; Pizzano, Jennifer; Quinn, Connor; Rose, Christopher M.; Rousseau, Emma; Sethuraman, Vijay; Staben, Leanna; Wilson, Catherine; Ye, Xiaofen; Broccatelli, Fabio; Yauch, Robert; Dragovich, Peter S. 分享 收藏
A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types Wagle, Marie-Claire; Kirouac, Daniel; Klijn, Christiaan; Liu, Bonnie; Mahajan, Shilpi; Junttila, Melissa; Moffat, John; Merchant, Mark; Huw, Ling; Wongchenko, Matthew; Okrah, Kwame; Srinivasan, Shrividhya; Mounir, Zineb; Sumiyoshi, Teiko; Haverty, Peter M.; Yauch, Robert L.; Yan, Yibing; Kabbarah, Omar; Hampton, Garret; Amler, Lukas; Ramanujan, Saroja; Lackner, Mark R.; Huang, Shih-Min A. 分享 收藏
分享 收藏
PRC2 mediated repression of SMARCA2 predicts for EZH2 inhibitor activity in tumors with SWI/SNF mutations Januario, Thomas; Ye, Xiaofen; Bainer, Russell; Alicke, Bruno; Solon, Margaret; Haley, Benjamin; Modrusan, Zora; Gould, Stephen; Koeppen, Hartmut; Yauch, Robert L. 分享 收藏
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice 介导小鼠抗肿瘤免疫抑制需要肿瘤和宿主细胞PD-L1 Lau, Janet; Cheung, Jeanne; Navarro, Armando; Lianoglou, Steve; Haley, Benjamin; Totpal, Klara; Sanders, Laura; Koeppen, Hartmut; Caplazi, Patrick; McBride, Jacqueline; Chiu, Henry; Hong, Rebecca; Grogan, Jane; Javinal, Vincent; Yauch, Robert; Irving, Bryan; Belvin, Marcia; Mellman, Ira; Kim, Jeong M.; Schmidt, Maike 分享 收藏
分享 收藏
.png){kind=icon}
.png){kind=icon}
.png)
CANCER RESEARCH.png)
.png){kind=icon}
分享.png){kind=icon}
收藏