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Inhibiting acute, axonal DLK palmitoylation is neuroprotective and avoids deleterious effects of cell-wide DLK inhibition 抑制急性、轴突DLK棕榈酰化具有神经保护作用,并可避免细胞整体DLK抑制的有害影响 Zhang, Xiaotian; Jeong, Heykyeong; Niu, Jingwen; Holland, Sabrina M.; Rotanz, Brittany N.; Gordon, John; Einarson, Margret B.; Childers, Wayne E.; Thomas, Gareth M. 分享 收藏
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Dependence of human immune cell type, and impact of IL-7R or TLR1/2 agonism, upon trastuzumab-mediated ADCC Bryant, Mark; Tut, Gokhan; Harrison, Neale; Welsh, Emma; Morano, Ines; Kaur, Arshpreet; Pegg, Ashley; Chan, Hujo; Li, Zhi; Cowley, Jamie; Brady, Catherine; Gordon, John; Barnes, Nicholas; Qureshi, Omar 分享 收藏
Impact of IL-2 and IL-7 on human regulatory T cell suppression and pembrolizumab-mediated reversal of human T cell exhaustion Tut, Gokhan; Harrison, Neale; Sallie, Leila; Welsh, Emma; Pegg, Ashley; Kaur, Arshpreet; Li, Zhi; Morano, Ines; Chan, Hujo; Cowley, Jamie; Brady, Catherine; Gordon, John; Bryant, Mark; Qureshi, Omar; Barnes, Nicholas M. 分享 收藏
Use of human predictive patch test (HPPT) data for the classification of skin sensitization hazard and potency Herzler, Matthias; Abedini, Jaleh; Allen, David G.; Germolec, Dori; Gordon, John; Ko, Hon-Sum; Matheson, Joanna; Reinke, Emily; Strickland, Judy; Thierse, Hermann-Josef; To, Kim; Truax, James; Vanselow, Jens T.; Kleinstreuer, Nicole 分享 收藏
A database of human predictive patch test data for skin sensitization Strickland, Judy; Abedini, Jaleh; Allen, David G.; Gordon, John; Hull, Victoria; Kleinstreuer, Nicole C.; Ko, Hon-Sum; Matheson, Joanna; Thierse, Hermann-Josef; Truax, James; Vanselow, Jens T.; Herzler, Matthias 分享 收藏
A framework for establishing scientific confidence in new approach methodologies van der Zalm, Anna J.; Barroso, Joao; Browne, Patience; Casey, Warren; Gordon, John; Henry, Tala R.; Kleinstreuer, Nicole C.; Lowit, Anna B.; Perron, Monique; Clippinger, Amy J. 分享 收藏
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Use of Cause-and-Effect Analysis to Optimize the Reliability of In Vitro Inhalation Toxicity Measurements Using an Air-Liquid Interface Petersen, Elijah J.; Sharma, Monita; Clippinger, Amy J.; Gordon, John; Katz, Aaron; Laux, Peter; Leibrock, Lars B.; Luch, Andreas; Matheson, Joanna; Stucki, Andreas O.; Tentschert, Jutta; Bierkandt, Frank S. 分享 收藏
Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation Roberts, Alexander; Bentley, Lindsay; Tang, Tina; Stewart, Fay; Pallini, Chiara; Juvvanapudi, Joel; Wallace, Graham R.; Cooper, Alison J.; Scott, Aaron; Thickett, David; Lugg, Sebastian T.; Bancroft, Hollie; Hemming, Bridget; Ferris, Charlotte; Langman, Gerald; Robinson, Andrew; Chapman, Joanne; Naidu, Babu; Pinkney, Thomas; Taylor, Graham S.; Brock, Kristian; Stamataki, Zania; Brady, Catherine A.; Curnow, S. John; Gordon, John; Qureshi, Omar; Barnes, Nicholas M. 分享 收藏
A robust enhancement of cytokine production in a human chronic activation model of T cell exhaustion in vitro through blockade of PD-1/PDL-1 interactions using pembrolizumab or nivolumab; correlation with dissociated tumor immune cell responses Qureshi, Omar S.; Roberts, Alexander; Bentley, Lindsay; Tang, Tina; Stewart, Fay; Wallace, Graham; Cooper, Alison; Scott, Aaron; Thickett, David; Naidu, Babu; Pinkney, Thomas; Taylor, Graham; Brock, Kristian; Healy, Louise; Stamataki, Zania; Brady, Catherine; Curnow, S. J.; Gordon, John; Barnes, Nicholas M. 分享 收藏
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Exploring current read-across applications and needs among selected US Federal Agencies Patlewicz, Grace; Lizarraga, Lucina E.; Rua, Diego; Allen, David G.; Daniel, Amber B.; Fitzpatrick, Suzanne C.; Garcia-Reyero, Natalia; Gordon, John; Hakkinen, Pertti; Howard, Angela S.; Karmaus, Agnes; Matheson, Joanna; Mumtaz, Moiz; Richarz, Andrea-Nicole; Ruiz, Patricia; Scarano, Louis; Yamada, Takashi; Kleinstreuer, Nicole 分享 收藏
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Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative chemical redesign: mechanisms and pathways to cell death Wasik, Agata M.; Gandy, Michael N.; McIldowie, Matthew; Holder, Michelle J.; Chamba, Anita; Challa, Anita; Lewis, Katie D.; Young, Stephen P.; Scheel-Toellner, Dagmar; Dyer, Martin J.; Barnes, Nicholas M.; Piggott, Matthew J.; Gordon, John 分享 收藏
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