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Integrating Machine Learning and Large Language Models to Advance Exploration of Electrochemical Reactions 整合机器学习和大语言模型推进电化学反应探索 Zheng, Zhiling; Florit, Federico; Jin, Brooke; Wu, Haoyang; Li, Shih-Cheng; Nandiwale, Kakasaheb Y.; Salazar, Chase A.; Mustakis, Jason G.; Green, William H.; Jensen, Klavs F. 分享 收藏
Chemoselective Saponification in the Synthesis of Danuglipron Facilitated with Trifluoroethanol Han, Lu; Li, Bryan; Wang, Ke; Damon, David B.; Magano, Javier; Maloney, Mark T.; Mustakis, Jason; Post, Ronald J.; Li, Ruizhi; Nguyen, Truong 分享 收藏
Probing the chemical 'reactome' with high-throughput experimentation data King-Smith, Emma; Berritt, Simon; Bernier, Louise; Hou, Xinjun; Klug-McLeod, Jacquelyn L.; Mustakis, Jason; Sach, Neal W.; Tucker, Joseph W.; Yang, Qingyi; Howard, Roger M.; Lee, Alpha A. 分享 收藏
Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block Algera, Russell F.; Allais, Christophe; Baldwin, Aaron F.; Busch, Torsten; Colombo, Federica; Colombo, Matteo; Depretz, Christelle; Dumond, Yves Rene; Faria Quintero, Andres R.; Heredia, Maria; Jung, Jorg; Lall, Amrita; Lee, Taegyo; Liu, Yizhou; Mandelli, Stefano; Mantel, Marvin; Morris, Ronald; Mustakis, Jason; Nguyen, Bao; Pearson, Robert; Piper, Jared L.; Ragan, John A.; Ruffin, Brigitte; Talicska, Courtney; Tcyrulnikov, Sergei; Uyeda, Christopher; Weekly, R. Matthew; Zeng, Ming 分享 收藏
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment Algera, Russell F.; Allais, Christophe; Baldwin, Aaron F.; Becirovic, Husein; Bowles, Paul; Brown, Adam R.; Buske, Jamie M.; Clarke, Hugh J.; Do, Nga M.; Doyle, Kevin; Fifer, Jonathan; Gray, Kaitlyn; Happe, Alan; Hardink, Mark; Hubbell, Aran K.; James, Chintelle; Khadamkar, Hrushikesh P.; Magano, Javier; McInturff, Emma L.; Mustakis, Jason; Ozbuyukkaya, Gizem; Piper, Jared L.; Place, David W.; Ragan, John A.; Rauschenberger, Blake; Reyes, Giselle; Shehadeh, Rawan; Stanchina, Corey; Stanley, Michael; Weekly, R. Matthew; Weinstein, Ethan; Weisenburger, Gerald A.; Wood, Ethan; Yayla, Hatice G.; Yu, Shu 分享 收藏
Machine learning directed multi-objective optimization of mixed variable chemical systems 面向机器学习的混合变量化工系统多目标优化 Kershaw, Oliver J.; Clayton, Adam D.; Manson, Jamie A.; Barthelme, Alexandre; Pavey, John; Peach, Philip; Mustakis, Jason; Howard, Roger M.; Chamberlain, Thomas W.; Warren, Nicholas J.; Bourne, Richard A. 分享 收藏
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Developing a Multistep Continuous Manufacturing Process for (1R,2R)-2-Amino-1-methylcyclopentan-1-ol Duan, Shengquan; Feng, Xichun; Gonzalez, Miguel; Bader, Scott; Hayward, Cheryl; Ljubicic, Tomislav; Lu, Jiangping; Mustakis, Jason; Maloney, Mark; Rainville, Joseph; Zhang, Xin 分享 收藏
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Applications of Quantum Chemistry in Pharmaceutical Process Development: Current State and Opportunities Lam, Yu-hong; Abramov, Yuriy; Ananthula, Ravi S.; Elward, Jennifer M.; Hilden, Lori R.; Lill, Sten O. Nilsson; Norrby, Per-Ola; Ramirez, Antonio; Sherer, Edward C.; Mustakis, Jason; Tanoury, Gerald J. 分享 收藏
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Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development Wang, Ke; Han, Lu; Mustakis, Jason; Li, Bryan; Magano, Javier; Damon, David B.; Dion, Amelie; Maloney, Mark T.; Post, Ronald; Li, Ruizhi 分享 收藏
Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium-Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib Li, Chengxi; Wan, Feng; Chen, Yuan; Peng, Henian; Tang, Wenjun; Yu, Shu; McWilliams, J. Christopher; Mustakis, Jason; Samp, Lacey; Maguire, Robert J. 分享 收藏
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Process Development and Scale Up of a Selective JAK3 Covalent Inhibitor PF-06651600 Tao, Yong; McWilliams, J. Christopher; Wiglesworth, Kristin E.; Girard, Kevin P.; Makowski, Teresa M.; Sach, Neal W.; Mustakis, Jason G.; Mehta, Ruchi; Trujillo, John I.; Chen, Xiaofeng; Li, Tangqing; Shi, Feng; Xie, Chengfu; Zhang, Qing 分享 收藏