Caroline J. Barelle - Publications, H-index & Citations

Caroline J. Barelle

elasmogen ltd.

23H指数

58论文数

2.2K被引数

收录论文 27

发表时间

A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload 一种通过理性设计的新型双功能人TNF-α和Janus激酶靶向的soloMER药物偶联物（SDC），其具有中性粒细胞弹性蛋白酶可裂解的连接子，能够实现炎症部位特异性释放有效载荷。

Journal of Medicinal Chemistry

IF6.8

2026-04-07

OAAI

Euan Murray; Stella Priyanka; Julia Martinez-Fraile; Ruslan Grygorash; Mohannad Idress; Luke C. Brownbridge; Stella Glavina; Nicolas Camper; Robert Boyd; Andrew J. Porter; Caroline J. Barelle; Obinna C. Ubah

The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors 鲨鱼可变新抗原受体对可溶性TNF-alpha选择性拮抗的结构基础

Nature Communications

IF15.7

2025-11-29

OAAI

Obinna C. Ubah; Eric W. Lake; Kendahl L. Ott; Stella Priyanka; Sasha Celeda; Jayden L. West; Gihan S. Gunaratne; Ke Shi; Nicholas H. Moeller; Andrew J. Porter; Hideki Aihara; David Kosoff; Aaron M. LeBeau; Caroline J. Barelle

Exploiting a multi-center pre-clinical mouse PDX mini trial to identify new clinical opportunities for protein-drug conjugates (PDCs) targeting ROR1

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Cranston, Aaron N.; Wappett, Mark; McLean, Estelle G.; Saladino, Chiara; McCann, Aidan; Kung, Wei-Wei; Thom, Jennifer; Trumper, Paul; Porter, Andy; Barelle, Caroline; Harrison, Tim; Cotton, Graham

Functionalization of polymeric nanoparticles with targeting VNAR ligands using vinyl sulfone conjugation

JOURNAL OF MATERIALS CHEMISTRY B

IF5.7

2023-01-01

OAAI

Leach, Adam; Finnegan, Marie; Machado, Mariana S.; Ferguson, Laura; Steven, John; Smyth, Peter; Porter, Andrew; Barelle, Caroline; Themistou, Efrosyni; Scott, Christopher J.

Enhancing the Transdermal Delivery of ?Next Generation? Variable New Antigen Receptors Using Microarray Patch Technology: a Proof-of-Concept Study

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2022-12-01

OAAI

Hutton, Aaron R. J.; Ubah, Obinna; Barelle, Caroline; Donnelly, Ryan F.

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

NATURE COMMUNICATIONS

IF15.7

2021-12-16

OAAI

Ubah, Obinna C.; Lake, Eric W.; Gunaratne, Gihan S.; Gallant, Joseph P.; Fernie, Marie; Robertson, Austin J.; Marchant, Jonathan S.; Bold, Tyler D.; Langlois, Ryan A.; Matchett, William E.; Thiede, Joshua M.; Shi, Ke; Yin, Lulu; Moeller, Nicholas H.; Banerjee, Surajit; Ferguson, Laura; Kovaleva, Marina; Porter, Andrew J.; Aihara, Hideki; LeBeau, Aaron M.; Barelle, Caroline J.

Development of next generation nanomedicine-based approaches for the treatment of cancer: we've barely scratched the surface

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2021-10-28

OAAI

Tracey, Shannon R.; Smyth, Peter; Barelle, Caroline J.; Scott, Christopher J.

Exploiting the properties of VNAR domains for the development of novel efficacious protein drug conjugates targeting the oncofetal protein ROR1

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Cotton, Graham; Thom, Jennifer; Trumper, Paul; Kamenski, Andrei; Bell, Stacey; Wappett, Mark; Barelle, Caroline; Kovaleva, Marina; Campion, Alicia; Persiani, Elisa; Porter, Andrew; McLean, Estelle; McCann, Aidan; Saladino, Chiara; Cranston, Aaron; Harrison, Tim

In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development

JOURNAL OF IMMUNOLOGY RESEARCH

IF3.6

2020-02-03

OAAI

Ubah, Obinna C.; Porter, Andrew J.; Barelle, Caroline J.

Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature

NANOSCALE

IF5.1

2020-01-01

OAAI

Leach, Adam; Smyth, Peter; Ferguson, Laura; Steven, John; Greene, Michelle K.; Branco, Cristina M.; McCann, Aidan P.; Porter, Andrew; Barelle, Caroline J.; Scott, Christopher J.

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

FRONTIERS IN IMMUNOLOGY

IF5.9

2019-03-22

OAAI

Ubah, Obinna C.; Steven, John; Porter, Andrew J.; Barelle, Caroline J.

Oriented attachment of VNAR proteins, via site-selective modification, on PLGA-PEG nanoparticles enhances nanoconjugate performance

CHEMICAL COMMUNICATIONS

IF4.2

2019-01-01

OAAI

Nogueira, Joao C. F.; Greene, Michelle K.; Richards, Daniel A.; Furby, Alexander O.; Steven, John; Porter, Andrew; Barelle, Caroline; Scott, Christopher J.; Chudasama, Vijay

Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2018-10-31

PREAI

Ubah, Obinna C.; Buschhaus, Magdalena J.; Ferguson, Laura; Kovaleva, Marina; Steven, John; Porter, Andrew J.; Barelle, Caroline J.

Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis

JOURNAL OF IMMUNOLOGY RESEARCH

IF3.6

2018-10-17

OAAI

O'Dwyer, Ronan; Kovaleva, Marina; Zhang, Jiquan; Steven, John; Cummins, Emma; Luxenberg, Deborah; Darmanin-Sheehan, Alfredo; Carvalho, Miguel F.; Whitters, Matthew; Saunders, Kenneth; Barelle, Caroline J.

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

FRONTIERS IN IMMUNOLOGY

IF5.9

2017-12-22

OAAI

Ubah, Obinna C.; Steven, John; Kovaleva, Marina; Ferguson, Laura; Barelle, Charlotte; Porter, Andrew J. R.; Barelle, Caroline J.

In Vitro Maturation of a humanized shark Vnar Domain to improve its Biophysical Properties to Facilitate clinical Development

FRONTIERS IN IMMUNOLOGY

IF5.9

2017-10-23

OAAI

Steven, John; Mueller, Mischa R.; Carvalho, Miguel F.; Ubah, Obinna C.; Kovaleva, Marina; Donohoe, Gerard; Baddeley, Thomas; Cornock, Dawn; Saunders, Kenneth; Porter, Andrew J.; Barelle, Caroline Jane

Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis

FRONTIERS IN IMMUNOLOGY

IF5.9

2017-09-25

OAAI

Kovaleva, Marina; Johnson, Katherine; Steven, John; Barelle, Caroline J.; Porter, Andrew

Structural insights and biomedical potential of IgNAR scaffolds from sharks

MABS

IF7.3

2015-01-14

119

OAAI

Zielonka, Stefan; Empting, Martin; Grzeschik, Julius; Koenning, Doreen; Barelle, Caroline J.; Kolmar, Harald

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

MABS

IF7.3

2014-10-30

106

OAAI

Mueller, Mischa R.; Saunders, Kenneth; Grace, Christopher; Jin, Macy; Piche-Nicholas, Nicole; Steven, John; O'Dwyer, Ronan; Wu, Leeying; Khetemenee, Lam; Vugmeyster, Yulia; Hickling, Timothy P.; Tchistiakova, Lioudmila; Olland, Stephane; Gill, Davinder; Jensen, Allan; Barelle, Caroline J.

Shark variable new antigen receptor biologics - a novel technology platform for therapeutic drug development

EXPERT OPINION ON BIOLOGICAL THERAPY

IF4

2014-08-04

OAAI

Kovaleva, Marina; Ferguson, Laura; Steven, John; Porter, Andrew; Barelle, Caroline

研究方向