Mathew J. Garnett

wellcome sanger institute

64H指数

545论文数

3.9W被引数

收录论文 97

发表时间

A tumour-derived organoid biobank maps cancer gene dependencies 肿瘤来源的类器官生物样本库绘制了癌症基因依赖图谱

Nature

IF48.5

2026-08-05

OAAI

C. Herranz-Ors; S. G. Bhosle; A. E. Beck; J. G. R. Gilbert; G. Picco; J. Espejo Valle-Inclan; F. Muyas; S. Valentini; A. E. Andres; R. Ansari; S. Barthorpe; G. Battarbee; C. M. Beaver; S. Brocklesby; J. Cantwell; C. A. Collins; J. Davis; H. G. Dimitrova; J. Doran; E. Efendi; K. Evans; M. Fekry; T. A. Fowler; M. Garcia-Casado; J. A. T. Griffiths; C. Hall; R. Hamer; C. Hardy; Z. Hewitson; E. Hitch; L. Holland; D. A. Jackson; N. Joshi; A. Kavasakali; L. Letchford; H. B. Lightfoot; H. Lingala; I. Mali; K. May; T. Mironenko; J. Morris; C. Pacini; S. Price; G. Robert-Tissot; H. A. Rogers; J. V. Smith; K. Smith; E. Souster; W. J. Spence; F. Thomas; S. F. Vieira; S. Walker; G. Alfonsin; H. Bermingham; H. Coles; D. P. Ennis; A. Freeman; G. Giannone; N. Grehan; E. A. Griffiths; J. Hall; S. L. Lee; E. Y. L. Leung; C. Loreno; C. Millington; A. Mirnezami; B. Nutzinger; K. Orzechowska; C. M. A. Pinna; A. M. Redmond; K. Roberts; S. Roy; D. A. Sanders; P. Taniere; M. Vias; K. Wanigasooriya; M. R. Stratton; L. M. Staudt; U. McDermott; J. D. Brenton; I. A. McNeish; A. Biankin; O. J. Sansom; I. Cortes-Ciriano; T. J. Underwood; R. C. Fitzgerald; A. D. Beggs; H. E. Francies; M. J. Garnett

A compendium of next-generation patient-derived models for diverse cancers 用于多种癌症的下一代患者来源模型汇编

Nature

IF48.5

2026-08-05

OAAI

Dina ElHarouni; Mushriq Al-Jazrawe; Seongmin Choi; Merve Dede; Toshinori Hinoue; Sean A. Misek; Heeju Noh; Luca Zanella; Yuen-Yi Tseng; Hayley E. Francies; Dennis Plenker; Cindy W. Kyi; Julyann Perez-Mayoral; Megan J. Stine; Eva Tonsing-Carter; Rachana Agarwal; Jean Claude Zenklusen; James M. Clinton; Jennifer M. Shelton; Timothy R. Chu; William F. Hooper; Xavi Loinaz; Paula Keskula; Jordan Tagle; Peyton C. Kuhlers; Bahar Tercan; Sylvia F. Boj; Alessandro Vasciaveo; Lorenzo Tomassoni; James M. Crawford; Shawna Walsh; Claire Sinai; Sonam Bhatia; Priya Sridevi; Hardik Patel; Maria Antonietta Cerone; Kyle Ellrott; Calvin J. Kuo; Olivier Elemento; Semir Beyaz; Vincenzo Corbo; David L. Spector; Rameen Beroukhim; Martin L. Ferguson; Andrew D. Cherniack; Peter W. Laird; Nicolas Robine; Andrew McPherson; Katherine A. Hoadley; Mathew J. Garnett; David A. Tuveson; Andrea Califano; Paul T. Spellman; Keith L. Ligon; Daniela S. Gerhard; Louis M. Staudt; Jesse S. Boehm

Large-scale drug sensitivity, gene dependency, and proteogenomic analyses of telomere maintenance mechanisms in cancer cells 大规模药物敏感性、基因依赖性和蛋白质基因组学分析，探讨癌细胞中端粒维持机制

Nature Communications

IF15.7

2025-12-23

OAAI

Yangxiu Wu; Zhaoxiang Cai; Dale Cross; Jane R. Noble; Kelsy Prest; Jamie Littleboy; Scott B. Cohen; Baylee Edlundh; Jennifer M. S. Koh; Ran Xu; Zainab Noor; Milad Bastami; Sara Valentini; Laura Richardson; Syd Barthorpe; Nader Arymanesh; Phillip J. Robinson; Peter G. Hains; Mathew J. Garnett; Qing Zhong; Roger R. Reddel; Karen L. MacKenzie

A next-generation dual guide CRISPR system for genetic interaction library screening 一种用于遗传互作文库筛选的下一代双引导CRISPR系统

Nature Communications

IF15.7

2025-12-06

OAAI

Thomas Burgold; Emre Karakoc; Emanuel Gonçalves; Inigo Barrio-Hernandez; Lisa Dwane; Romina Silva; Emily Souster; Mamta Sharma; Alexandra Beck; Gene Ching Chiek Koh; Lykourgos-Panagiotis Zalmas; Mathew J. Garnett; Andrew R. Bassett

Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma

MOLECULAR CARCINOGENESIS

IF3.2

2025-03-01

PREAI

Yee, Pei San; Chai, Annie Wai Yeeng; Yee, Shi Mun; Ooi, Shiyin; Tan, Yee Hua; Garnett, Mathew J.; Ng, Siew Kit; Cheong, Sok Ching

Benchmark Software and Data for Evaluating CRISPR-Cas9 Experimental Pipelines Through the Assessment of a Calibration Screen

CRISPR JOURNAL

IF4

2024-12-01

OAAI

Iannuzzi, Raffaele M.; Manipur, Ichcha; Pacini, Clare; Behan, Fiona M.; Guarracino, Mario R.; Garnett, Mathew J.; Savino, Aurora; Iorio, Francesco

Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning

NATURE COMMUNICATIONS

IF15.7

2024-11-29

OAAI

Cai, Zhaoxiang; Apolinario, Sofia; Baiao, Ana R.; Pacini, Clare; Sousa, Miguel D.; Vinga, Susana; Reddel, Roger R.; Robinson, Phillip J.; Garnett, Mathew J.; Zhong, Qing; Goncalves, Emanuel

Base editing screens define the genetic landscape of cancer drug resistance mechanisms

NATURE GENETICS

IF31.8

2024-10-18

OAAI

Coelho, Matthew A.; Strauss, Magdalena E.; Watterson, Alex; Cooper, Sarah; Bhosle, Shriram; Illuzzi, Giuditta; Karakoc, Emre; Dincer, Cansu; Vieira, Sara F.; Sharma, Mamta; Moullet, Marie; Conticelli, Daniela; Koeppel, Jonas; Mccarten, Katrina; Cattaneo, Chiara M.; Veninga, Vivien; Picco, Gabriele; Parts, Leopold; Forment, Josep V.; Voest, Emile E.; Marioni, John C.; Bassett, Andrew; Garnett, Mathew J.

On-target mutations drive resistance to WRN helicase inhibitors in microsatellite unstable colorectal cancer

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Picco, G.; Rao, Y.; Al Saedi, A.; Vieira, S.; Lee, Y.; Walker, S.; Bhosle, S.; May, K.; Taygerly, J.; Jones, B.; Coelho, M.; Houseley, J.; Sharma, G.; Schwartz, B.; Garnett, M.

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities 癌症药物耐受性持久细胞: 从生物学问题到临床机会

NATURE REVIEWS CANCER

IF66.8

2024-09-02

PREAI

Russo, Mariangela; Chen, Mengnuo; Mariella, Elisa; Peng, Haoning; Rehman, Sumaiyah K.; Sancho, Elena; Sogari, Alberto; Toh, Tzen S.; Balaban, Nathalie Q.; Batlle, Eduard; Bernards, Rene; Garnett, Mathew J.; Hangauer, Matthew; Leucci, Eleonora; Marine, Jean-Christophe; O'Brien, Catherine A.; Oren, Yaara; Patton, E. Elizabeth; Robert, Caroline; Rosenberg, Susan M.; Shen, Shensi; Bardelli, Alberto

Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-06-10

PREAI

Picco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Lee, Yang; Bhosle, Shriram; Herranz-Ors, Carmen; Walker, Samantha; May, Kieron; Coelho, Matthew; Houseley, Jon; Schwartz, Benjamin; Garnett, Mathew J.

Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells

CANCER DISCOVERY

IF33.3

2024-04-06

PREAI

Picco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Lee, Yang; Vieira, Sara F.; Bhosle, Shriram; May, Kieron; Herranz-Ors, Carmen; Walker, Samantha J.; Shenje, Raynold; Dincer, Cansu; Gibson, Freddy; Banerjee, Ruby; Hewitson, Zoe; Werner, Thilo; Cottom, Joshua E.; Peng, Yang; Deng, Nanhua; Zhang, Youyou; Nartey, Eldridge N.; Nickels, Leng; Landis, Philip; Conticelli, Daniela; McCarten, Katrina; Bush, Jacob; Sharma, Mamta; Lightfoot, Howard; House, David; Milford, Emma; Grant, Emma K.; Glogowski, Michal P.; Wagner, Craig D.; Bantscheff, Marcus; Rutkowska-Klute, Anna; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, H. Christian; Jones, Brian T.; Schneck, Jessica L.; Murphy, Dennis J.; Voest, Emile E.; Taygerly, Joshua P.; DeMartino, Michael P.; Coelho, Matthew A.; Houseley, Jonathan; Sharma, Geeta; Schwartz, Benjamin; Garnett, Mathew J.

Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Picco, Gabriele; Rao, Yanhua; Al Saedi, Angham; Vieira, Sara F.; Lee, Yang; Shenje, Ray; Bhosle, Shriram; Walker, Samantha; May, Kieron; Herranz-Ors, Carmen; Dicer, Cansu; Gibson, Freddy; Banerjee, Ruby; Werner, Thilo; Cottom, Josh; Peng, Yang; Deng, Nanhua; Landis, Phil; Angel, Thomas; Bush, Jacob; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Lightfoot, Howard; Zappacosta, Francesca; Pettinger, Jonathan; Barthorpe, Syd; Eberl, Chris; Jones, Brian; Schneck, Jess; Murphy, Dennis; Taygerly, Josh; DeMartino, Mike; Coelho, Matthew; Houseley, Jon; Schwartz, Benjamin; Garnett, Mathew J.

Haplotype-specific assembly of shattered chromosomes in esophageal adenocarcinomas

CELL GENOMICS

IF9

2024-02-01

OAAI

Ijaz, Jannat; Harry, Edward; Raine, Keiran; Menzies, Andrew; Beal, Kathryn; Quail, Michael A.; Zumalave, Sonia; Jung, Hyunchul; Coorens, Tim H. H.; Lawson, Andrew R. J.; Leongamornlert, Daniel; Francies, Hayley E.; Garnett, Mathew J.; Ning, Zemin; Campbell, Peter J.

Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2024-01-17

OAAI

Garcia, Angela L. Caipa; Kucab, Jill E.; Al-Serori, Halh; Beck, Rebekah S. S.; Bellamri, Madjda; Turesky, Robert J.; Groopman, John D.; Francies, Hayley E.; Garnett, Mathew J.; Huch, Meritxell; Drost, Jarno; Zilbauer, Matthias; Arlt, Volker M.; Phillips, David H.

scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics

GENOME BIOLOGY

IF9.4

2024-01-15

OAAI

Cooper, Sarah E.; Coelho, Matthew A.; Strauss, Magdalena E.; Gontarczyk, Aleksander M.; Wu, Qianxin; Garnett, Mathew J.; Marioni, John C.; Bassett, Andrew R.

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

EUROPEAN RESPIRATORY JOURNAL

IF21

2024-01-11

OAAI

Obacz, Joanna; Valer, Jose Antonio; Nibhani, Reshma; Adams, Taylor S.; Schupp, Jonas C.; Veale, Niki; Lewis-Wade, Amanah; Flint, Jasper; Hogan, John; Aresu, Giuseppe; Coonar, Aman S.; Peryt, Adam; Biffi, Giulia; Kaminski, Naftali; Francies, Hayley; Rassl, Doris M.; Garnett, Mathew J.; Rintoul, Robert C.; Marciniak, Stefan J.

Integrative analyses of CRISPR and drug screens identify a selective and potent compound for oral squamous cell carcinoma

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Chai, Annie Wai Yeeng; Tan, Yee Hua; Ooi, Shiyin; Yee, Pei San; Yee, Shi Mun; Lightfoot, Howard; Bathorpe, Syd; Garnett, Mathew J.; Cheong, Sok Ching

Highlights from the 1st European cancer dependency map symposium and workshop

FEBS LETTERS

IF3

2023-07-24

OAAI

Trastulla, Lucia; Savino, Aurora; Beltrao, Pedro; Ciriano, Isidro Cortes; Fenici, Peter; Garnett, Mathew J. J.; Guerini, Ilaria; Bigas, Nuria Lopez; Mattaj, Iain; Petsalaki, Evangelia; Riva, Laura; Tape, Christopher J. J.; Sharma, Sumana; Vazquez, Francisca; Iorio, Francesco

A landscape of response to drug combinations in non-small cell lung cancer

NATURE COMMUNICATIONS

IF15.7

2023-06-28

OAAI

Nair, Nishanth Ulhas; Greninger, Patricia; Zhang, Xiaohu; Friedman, Adam A.; Amzallag, Arnaud; Cortez, Eliane; Sahu, Avinash Das; Lee, Joo Sang; Dastur, Anahita; Egan, Regina K.; Murchie, Ellen; Ceribelli, Michele; Crowther, Giovanna S.; Beck, Erin; McClanaghan, Joseph; Klump-Thomas, Carleen; Boisvert, Jessica L.; Damon, Leah J.; Wilson, Kelli M.; Ho, Jeffrey; Tam, Angela; McKnight, Crystal; Michael, Sam; Itkin, Zina; Garnett, Mathew J.; Engelman, Jeffrey A.; Haber, Daniel A.; Thomas, Craig J.; Ruppin, Eytan; Benes, Cyril H.

研究方向