未登录 Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas SEA-CD40的1期剂量递增研究: 非岩藻糖基化CD40激动剂，用于晚期实体瘤和淋巴瘤 Coveler, Andrew L.; Smith, David C.; Phillips, Tycel; Curti, Brendan D.; Goel, Sanjay; Mehta, Amitkumar N.; Kuzel, Timothy M.; Markovic, Svetomir N.; Rixe, Olivier; Bajor, David L.; Gajewski, Thomas F.; Gutierrez, Martin; Lee, Hun Ju; Gopal, Ajay K.; Caimi, Paolo; Heath, Elisabeth, I; Thompson, John A.; Ansari, Sahar; Jacquemont, Celine; Topletz-Erickson, Ariel; Zhou, Peigen; Schmitt, Michael W.; Grilley-Olson, Juneko E. 分享 收藏
CD4+ T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV Wanjalla, Celestine N.; Gabriel, Curtis L.; Fuseini, Hubaida; Bailin, Samuel S.; Mashayekhi, Mona; Simmons, Joshua; Warren, Christopher M.; Glass, David R.; Oakes, Jared; Gangula, Rama; Wilfong, Erin; Priest, Stephen; Temu, Tecla; Newell, Evan W.; Pakala, Suman; Kalams, Spyros A.; Gianella, Sara; Smith, David; Harrison, David G.; Mallal, Simon A.; Koethe, John R. 分享 收藏
First-in-Human Study of INCB062079, a Fibroblast Growth Factor Receptor 4 Inhibitor, in Patients with Advanced Solid Tumors Harding, James J. J.; Jungels, Christiane; Machiels, Jean-Pascal; Smith, David C. C.; Walker, Chris; Ji, Tao; Jiang, Ping; Li, Xin; Asatiani, Ekaterine; Van Cutsem, Eric; Abou-Alfa, Ghassan K. K. 分享 收藏
A Phase 2 Trial of Nab-paclitaxel in Combination With Anti-PD1 Therapy in Advanced Urothelial Cancer Tsung, Irene; Green, Edward; Palmbos, Phillip; Sloan, Zachery; Reichert, Zachery R.; Vaishampayan, Ulka; Smith, David C.; Caram, Megan E. V.; Yentz, Sarah; Daignault-Newton, Stephanie; Hurley, Laura; Nguyen, Charles B.; Kraft, Shawna; Alva, Ajjai 分享 收藏
FIGHT-101, a first-in-human study of potent and selective FGFR 1-3 inhibitor pemigatinib in pan-cancer patients with FGF/FGFR alterations and advanced malignancies Subbiah, V; Iannotti, N. O.; Gutierrez, M.; Smith, D. C.; Feliz, L.; Lihou, C. F.; Tian, C.; Silverman, I. M.; Ji, T.; Saleh, M. 分享 收藏
Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours Rodon, Jordi; Argiles, Guillem; Connolly, Roisin M.; Vaishampayan, Ulka; de Jonge, Maja; Garralda, Elena; Giannakis, Marios; Smith, David C.; Dobson, Jason R.; McLaughlin, Margaret E.; Seroutou, Abdelkader; Ji, Yan; Morawiak, Jennifer; Moody, Susan E.; Janku, Filip 分享 收藏
Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer Voss, Martin H.; Gordon, Michael S.; Mita, Monica; Rini, Brian; Makker, Vicky; Macarulla, Teresa; Smith, David C.; Cervantes, Andres; Puzanov, Igor; Pili, Roberto; Wang, Ding; Jalal, Shadia; Pant, Shubham; Patel, Manish R.; Neuwirth, Rachel L.; Enke, Aaron; Shou, Yaping; Sedarati, Farhad; Faller, Douglas V.; Burris, Howard A., III 分享 收藏
SEA-CD40 is a non-fucosylated anti-CD40 antibody with potent pharmacodynamic activity in preclinical models and patients with advanced solid tumors Neff-LaFord, Haley; Grilley-Olson, Juneko E.; Smith, David C.; Curti, Brendan; Goel, Sanjay; Kuzel, Timothy M.; Markovic, Svetomir N.; Rixe, Olivier; Bajor, David L.; Gajewski, Thomas F.; Gutierrez, Martin; Heath, Elisabeth I.; Thompson, John; Ansari, Sahar; Gardai, Shyra; Jacquemont, Celine; Schmitt, Michael; Coveler, Andrew L. 分享 收藏
Development of 2 Bromodomain and Extraterminal Inhibitors With Distinct Pharmacokinetic and Pharmacodynamic Profiles for the Treatment of Advanced Malignancies Falchook, Gerald; Rosen, Seth; LoRusso, Patricia; Watts, Justin; Gupta, Shilpa; Coombs, Catherine C.; Talpaz, Moshe; Kurzrock, Razelle; Mita, Monica; Cassaday, Ryan; Harb, Wael; Peguero, Julio; Smith, David C.; Piha-Paul, Sarina A.; Szmulewitz, Russ; Noel, Marcus S.; Yeleswaram, Swamy; Liu, Phillip; Switzky, Julie; Zhou, Gongfu; Zheng, Fred; Mehta, Amitkumar 分享 收藏
A phase 1 study of nevanimibe HCl, a novel adrenal-specific sterol O-acyltransferase 1 (SOAT1) inhibitor, in adrenocortical carcinoma Smith, David C.; Kroiss, Matthias; Kebebew, Electron; Habra, Mouhammed Amir; Chugh, Rashmi; Schneider, Bryan J.; Fassnacht, Martin; Jafarinasabian, Pegah; Ijzerman, M. Marian; Lin, Vivian H.; Mohideen, Pharis; Naing, Aung 分享 收藏
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FIGHT-101: A phase 1/2 study of pemigatinib, a highly selective fibroblast growth factor receptor (FGFR) inhibitor, as monotherapy and as combination therapy in patients with advanced malignancies Subbiah, Vivek; Barve, Minal; Iannotti, Nicholas O.; Gutierrez, Martin; Smith, David C.; Roychowdhury, Sameek; Papadopoulos, Kyriakos P.; Mettu, Niharika; Edenfield, William J.; Morgensztern, Daniel; Feliz, Luis; Lihou, Christine; Zhen, Huiling; Saleh, Mansoor 分享 收藏
Testicular Cancer, Version 2.2020 Gilligan, Timothy; Lin, Daniel W.; Aggarwal, Rahul; Chism, David; Cost, Nicholas; Derweesh, Ithaar H.; Emamekhoo, Hamid; Feldman, Darren R.; Geynisman, Daniel M.; Hancock, Steven L.; LaGrange, Chad; Levine, Ellis G.; Longo, Thomas; Lowrance, Will; McGregor, Bradley; Monk, Paul; Picus, Joel; Pierorazio, Phillip; Rais-Bahrami, Soroush; Saylor, Philip; Sircar, Kanishka; Smith, David C.; Tzou, Katherine; Vaena, Daniel; Vaughn, David; Yamoah, Kosj; Yamzon, Jonathan; Johnson-Chilla, Alyse; Keller, Jennifer; Pluchino, Lenora A. 分享 收藏
A phase 1 trial of SGN-CD70A in patients with CD70-positive, metastatic renal cell carcinoma Pal, Sumanta K.; Forero-Torres, Andres; Thompson, John A.; Morris, John C.; Chhabra, Saurabh; Holmes, Christopher J.; Vogelzang, Nicholas J.; Boyd, Thomas; Bergerot, Paulo G.; Adashek, Jacob J.; Li, Hong; Yu, Xuesong; Gartner, Elaina M.; Carret, Anne-Sophie; Smith, David C. 分享 收藏
A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors Smith, David C.; Chugh, Rashmi; Patnaik, Amita; Papadopoulos, Kyriakos P.; Wang, Min; Kapoun, Ann M.; Xu, Lu; Dupont, Jakob; Stagg, Robert J.; Tolcher, Anthony 分享 收藏
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A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumors Jimeno, Antonio; Moore, Kathleen N.; Gordon, Michael; Chugh, Rashmi; Diamond, Jennifer R.; Aljumaily, Raid; Mendelson, David; Kapoun, Ann M.; Xu, Lu; Stagg, Robert; Smith, David C. 分享 收藏
Castration Remains Despite Decreasing Definitive Treatment of Localized Prostate Cancer in the Elderly: A Case for De-Implementation Skolarus, Ted A.; Caram, Megan E. V.; Chapman, Christina H.; Smith, David C.; Hollenbeck, Brent K.; Hawley, Sarah; Tsodikov, Alexander; Sales, Anne; Wittmann, Daniela; Zaslavsky, Alexander 分享 收藏
A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma Phillips, Tycel; Barr, Paul M.; Park, Steven I.; Kolibaba, Kathryn; Caimi, Paolo F.; Chhabra, Saurabh; Kingsley, Edwin C.; Boyd, Thomas; Chen, Robert; Carret, Anne-Sophie; Gartner, Elaina M.; Li, Hong; Yu, Cindy; Smith, David C. 分享 收藏
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