未登录 Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity Jian, Xinyun; Wang, Cheng; Wu, Shijuan; Sun, Guo; Huang, Chuan; Qiu, Chengbing; Liu, Yuanzheng; Leadlay, Peter F.; Liu, Dong; Deng, Zixin; Zhou, Fuling; Sun, Yuhui 分享 收藏
Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis de Oliveira, Gabriel S.; Bury, Priscila dos S.; Huang, Fanglu; Li, Yuan; de Araujo, Natalia C.; Zhou, Jiahai; Sun, Yuhui; Leeper, Finian J.; Leadlay, Peter F.; Dias, Marcio V. B. 分享 收藏
Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition Zhai, Guifa; Zhu, Yan; Sun, Guo; Zhou, Fan; Sun, Yangning; Hong, Zhou; Dong, Chuan; Leadlay, Peter F.; Hong, Kui; Deng, Zixin; Zhou, Fuling; Sun, Yuhui 分享 收藏
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Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis Li, Sicong; Bury, Priscila dos Santos; Huang, Fanglu; Guo, Junhong; Sun, Guo; Reva, Anna; Huang, Chuan; Jian, Xinyun; Li, Yuan; Zhou, Jiahai; Deng, Zixin; Leeper, Finian J.; Leadlay, Peter F.; Dias, Marcio V. B.; Sun, Yuhui 分享 收藏
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Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase Zhai, Guifa; Wang, Wenyan; Xu, Wei; Sun, Guo; Hu, Chaoqun; Wu, Xiangming; Cong, Zisong; Deng, Liang; Shi, Yanrong; Leadlay, Peter F.; Song, Heng; Hong, Kui; Deng, Zixin; Sun, Yuhui 分享 收藏
Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase 具有3-羟基苯甲酸酯部分的缩肽的生物合成和选择性抗癌活性涉及chorismatase Shen, Yaoyao; Sun, Fan; Zhang, Liu; Cheng, Yijia; Zhu, Hongrui; Wang, Shu-Ping; Jiao, Wei-Hua; Leadlay, Peter F.; Zhou, Yongjun; Lin, Hou-Wen 分享 收藏
Sarpeptins A and B, Lipopeptides Produced by Streptomyces sp. KO-7888 Overexpressing a Specific SARP Regulator Koomsiri, Wilaiwan; Inahashi, Yuki; Leetanasaksakul, Kantinan; Shiomi, Kazuro; Takahashi, Yoko; Omura, Satoshi; Samborskyy, Markiyan; Leadlay, Peter F.; Wattana-Amorn, Pakorn; Thamchaipenet, Arinthip; Nakashima, Takuji 分享 收藏
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Directed Accumulation of Anticancer Depsipeptides by Characterization of Neoantimycins Biosynthetic Pathway and an NADPH-Dependent Reductase Zhou, Yongjun; Lin, Xiao; Williams, Simon R.; Liu, Liyun; Shen, Yaoyao; Wang, Shu-Ping; Sun, Fan; Xu, Shihai; Deng, Hai; Leadlay, Peter F.; Lin, Hou-Wen 分享 收藏
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Diversity oriented biosynthesis via accelerated evolution of modular gene clusters Wlodek, Aleksandra; Kendrew, Steve G.; Coates, Nigel J.; Hold, Adam; Pogwizd, Joanna; Rudder, Steven; Sheehan, Lesley S.; Higginbotham, Sarah J.; Stanley-Smith, Anna E.; Warneck, Tony; Nur-E-Alam, Mohammad; Radzom, Markus; Martin, Christine J.; Overvoorde, Lois; Samborskyy, Markiyan; Alt, Silke; Heine, Daniel; Carter, Guy T.; Graziani, Edmund I.; Koehn, Frank E.; McDonald, Leonard; Alanine, Alexander; Sarmiento, Rosa Maria Rodriguez; Chao, Suzan Keen; Ratni, Hasane; Steward, Lucinda; Norville, Isobel H.; Sarkar-Tyson, Mitali; Moss, Steven J.; Leadlay, Peter F.; Wilkinson, Barrie; Gregory, Matthew A. 分享 收藏
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An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain Xu, Wei; Zhai, Guifa; Liu, Yuanzhen; Li, Yuan; Shi, Yanrong; Hong, Kui; Hong, Hui; Leadlay, Peter F.; Deng, Zixin; Sun, Yuhui 分享 收藏
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