未登录 BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models Rauh, Ulrike; Wei, Guo; Serrano-Wu, Michael; Kosmidis, Georgios; Kaulfuss, Stefan; Siegel, Franziska; Thede, Kai; Mcfarland, James; Lemke, Christopher T.; Werbeck, Nicolas; Nowak-Reppel, Katrin; Pilari, Sabine; Menz, Stephan; Ocker, Matthias; Zhang, Weiqun; Davis, Kyle; Poncet-Montange, Guillaume; Roth, Jennifer; Daniels, Douglas; Kaushik, Virendar K.; Hubbard, Brian; Ziegelbauer, Karl; Golub, Todd R. 分享 收藏
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Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries Misek, Sean A.; Fultineer, Aaron; Kalfon, Jeremie; Noorbakhsh, Javad; Boyle, Isabella; Roy, Priyanka; Dempster, Joshua; Petronio, Lia; Huang, Katherine; Saadat, Alham; Green, Thomas; Brown, Adam; Doench, John G.; Root, David E.; McFarland, James M.; Beroukhim, Rameen; Boehm, Jesse S. 分享 收藏
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Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal 当基因敲除是全致死性时，部分CRISPR-Cas9抑制可改善对癌症脆弱性的识别 Krill-Burger, J. Michael; Dempster, Joshua M.; Borah, Ashir A.; Paolella, Brenton R.; Root, David E.; Golub, Todd R.; Boehm, Jesse S.; Hahn, William C.; McFarland, James M.; Vazquez, Francisca; Tsherniak, Aviad 分享 收藏
DELINEATING MEDIATORS OF ONCOGENESIS IN FOXR2-EXPRESSING DIFFUSE MIDLINE GLIOMAS Tsai, Jessica; Cejas, Paloma; Coppola, Marissa; Wang, Dayle; Patel, Smruti; Wu, David; Arounleut, Phonepasong; Wei, Xin; Zhou, Ningxuan; Syamala, Sudeepa; Dubois, Frank; Pelton, Kristine; Vogelzang, Jayne; Sousa, Cecilia; Baguette, Audrey; Chen, Xiaolong; Condurat, Alexandra; Dixon-Clarke, Sarah; Zhou, Kevin; Lu, Sophie; Gonzalez, Elizabeth; Chacon, Madison; Digiacomo, Jeromy; Kumbhani, Rushil; Novikov, Dana; Tsoli, Maria; Ziegler, David; Dirksen, Uta; Jager, Natalie; Balsubramanian, Gnana Prakash; Kramm, Christof; Nathrath, Michaela; Bielack, Stefan; Baker, Suzanne; Zhang, Jinghui; McFarland, James; Getz, Gad; Aguet, Francois; Jabado, Nada; Witt, Olaf; Pfister, Stefan; Ligon, Keith; Hovestadt, Volker; Kleinman, Claudia; Long, Henry; Jones, David; Bandopadhayay, Pratiti; Phoenix, Timothy 分享 收藏
Defining the landscape of cancer vulnerabilities that are engendered by germline genetic variation Misek, Sean; Fultineer, Aaron; Kalfon, Jeremie; Noorbakhsh, Javad; Boyle, Isabella; Dempster, Joshua; Petronio, Lia; Huang, Katherine; Green, Thomas; Brown, Adam; Doench, John; Root, David; McFarland, James; Beroukhim, Rameen; Boehm, Jesse 分享 收藏
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias Simoes, Ricardo de Matos; Shirasaki, Ryosuke; Downey-Kopyscinski, Sondra L.; Matthews, Geoffrey M.; Barwick, Benjamin G.; Gupta, Vikas A.; Dupere-Richer, Daphne; Yamano, Shizuka; Hu, Yiguo; Sheffer, Michal; Dhimolea, Eugen; Dashevsky, Olga; Gandolfi, Sara; Ishiguro, Kazuya; Meyers, Robin M.; Bryan, Jordan G.; Dharia, Neekesh V.; Hengeveld, Paul J.; Bruggenthies, Johanna B.; Tang, Huihui; Aguirre, Andrew J.; Sievers, Quinlan L.; Ebert, Benjamin L.; Glassner, Brian J.; Ott, Christopher J.; Bradner, James E.; Kwiatkowski, Nicholas P.; Auclair, Daniel; Levy, Joan; Keats, Jonathan J.; Groen, Richard W. J.; Gray, Nathanael S.; Culhane, Aedin C.; McFarland, James M.; Dempster, Joshua M.; Licht, Jonathan D.; Boise, Lawrence H.; Hahn, William C.; Vazquez, Francisca; Tsherniak, Aviad; Mitsiades, Constantine S. 分享 收藏
Rapid label-free imaging-based evaluation of cancer dependencies in zero-passage primary cells Al-Jazrawe, Mushriq; Molnar, Csaba; Abeyta, Elisabeth; Blum, Steven; Rindtorff, Niklas; Cebula, Kathryn; Misek, Sean; Alimova, Maria; Colgan, William; Rios, Carmen; Tseng, Moony; McFarland, James; Regev, Aviv; Cimini, Beth; Carpenter, Anne; Bass, Adam; Klempner, Samuel; Boehm, Jesse 分享 收藏
Dissecting mechanisms underlying FOXR2-mediated gliomagenesis in diffuse midline gliomas Tsai, Jessica W.; Cejas, Paloma; Coppola, Marissa; Wang, Dayle K.; Patel, Smruti; Wu, David W.; Arounleut, Phonepasong; Wei, Xin; Zhou, Ningxuan; Syamala, Sudeepa; Dubois, Frank P.; Pelton, Kristine; Vogelzang, Jayne; Sousa, Cecilia; Baguette, Audrey; Chen, Xiaolong; Condurat, Alexandra L.; Dixon-Clarke, Sarah E.; Charles, Annarah; Zhou, Kevin N.; Lu, Sophie D.; Gonzalez, Elizabeth M.; Chacon, Madison S.; Digiacomo, Jeromy J.; Kumbhani, Rushil; Novikov, Dana; Tsoli, Maria; Ziegler, David S.; Dirksen, Uta; Jager, Natalie; Balasubramanian, Gnana Prakash; Kramm, Christof M.; Nathrath, Michaela; Bielack, Stefan; Baker, Suzanne J.; Zhang, Jinghui; McFarland, James M.; Getz, Gad; Aguet, Francois; Jabado, Nada; Witt, Olaf; Pfister, Stefan M.; Ligon, Keith L.; Hovestadt, Volker; Kleinman, Claudia; Long, Henry; Jones, David T.; Bandopadhayay, Pratiti; Phoenix, Timothy N. 分享 收藏
ANJ810 is a highly selective novel MCL1 inhibitor with optimized in vivo clearance showing robust efficacy in preclinical solid and hematological tumor models Rauh, Ulrike; Wei, Guo; Serrano-Wu, Michael; Kosmidis, Georgios; Kaulfuss, Stefan; Siegel, Franziska; Thede, Kai; McFarland, James; Lemke, Christopher; Werbeck, Nicolas; Nowak-Reppel, Katrin; Pillari, Sabine; Menz, Stephan; Ocker, Matthias; Hubbard, Brian; Kaushik, Virendar; Ziegelbauer, Karl; Golub, Todd 分享 收藏
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas Cervia, Lisa D.; Shibue, Tsukasa; Borah, Ashir A.; Gaeta, Benjamin; He, Linh; Leung, Lisa; Li, Naomi; Moyer, Sydney M.; Shim, Brian H.; Dumont, Nancy; Gonzalez, Alfredo; Bick, Nolan R.; Kazachkova, Mariya; Dempster, Joshua M.; Krill-Burger, John Michael; Piccioni, Federica; Udeshi, Namrata D.; Olive, Meagan E.; Carr, Steven A.; Root, David E.; McFarland, James M.; Vazquez, Francisca; Hahn, William C. 分享 收藏
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FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits Tsai, Jessica W.; Cejas, Paloma; Wang, Dayle K.; Patel, Smruti; Wu, David W.; Arounleut, Phonepasong; Wei, Xin; Zhou, Ningxuan; Syamala, Sudeepa; Dubois, Frank P. B.; Crane, Alexander; Pelton, Kristine; Vogelzang, Jayne; Sousa, Cecilia; Baguette, Audrey; Chen, Xiaolong; Condurat, Alexandra L.; Dixon-Clarke, Sarah E.; Zhou, Kevin N.; Lu, Sophie D.; Gonzalez, Elizabeth M.; Chacon, Madison S.; Digiacomo, Jeromy J.; Kumbhani, Rushil; Novikov, Dana; Hunter, J'Ya; Tsoli, Maria; Ziegler, David S.; Dirksen, Uta; Jager, Natalie; Balasubramanian, Gnana Prakash; Kramm, Christof M.; Nathrath, Michaela; Bielack, Stefan; Baker, Suzanne J.; Zhang, Jinghui; McFarland, James M.; Getz, Gad; Aguet, Francois; Jabado, Nada; Witt, Olaf; Pfister, Stefan M.; Ligon, Keith L.; Hovestadt, Volker; Kleinman, Claudia L.; Long, Henry; Jones, David T. W.; Bandopadhayay, Pratiti; Phoenix, Timothy N. 分享 收藏
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer Bondeson, Daniel P.; Paolella, Brenton R.; Asfaw, Adhana; Rothberg, Michael, V; Skipper, Thomas A.; Langan, Carly; Mesa, Gabriel; Gonzalez, Alfredo; Surface, Lauren E.; Ito, Kentaro; Kazachkova, Mariya; Colgan, William N.; Warren, Allison; Dempster, Joshua M.; Krill-Burger, John M.; Ericsson, Maria; Tang, Andrew A.; Fung, Iris; Chambers, Emily S.; Abdusamad, Mai; Dumont, Nancy; Doench, John G.; Piccioni, Federica; Root, David E.; Boehm, Jesse; Hahn, William C.; Mannstadt, Michael; McFarland, James M.; Vazquez, Francisca; Golub, Todd R. 分享 收藏
Sparse dictionary learning recovers pleiotropy from human cell fitness screens Pan, Joshua; Kwon, Jason J.; Talamas, Jessica A.; Borah, Ashir A.; Vazquez, Francisca; Boehm, Jesse S.; Tsherniak, Aviad; Zitnik, Marinka; McFarland, James M.; Hahn, William C. 分享 收藏
A ubiquitination cascade regulating the integrated stress response and survival in carcinomas Cervia, Lisa D.; Shibue, Tsukasa; Gaeta, Benjamin; Borah, Ashir A.; Leung, Lisa; Li, Naomi; Dumont, Nancy; Gonzalez, Alfredo; Bick, Nolan; Kazachkova, Mariya; Dempster, Joshua M.; Krill-Burger, John M.; Piccioni, Federica; Udeshi, Namrata D.; Olive, Meagan E.; Carr, Steven A.; Root, David E.; McFarland, James M.; Vazquez, Francisca; Hahn, William C. 分享 收藏
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Gene Fusions Create Partner and Collateral Dependencies Essential to Cancer Cell Survival Gillani, Riaz; Seong, Bo Kyung A.; Crowdis, Jett; Conway, Jake R.; Dharia, Neekesh V.; Alimohamed, Saif; Haas, Brian J.; Han, Kyuho; Park, Jihye; Dietlein, Felix; He, Meng Xiao; Imamovic, Alma; Ma, Clement; Bassik, Michael C.; Boehm, Jesse S.; Vazquez, Francisca; Gusev, Alexander; Liu, David; Janeway, Katherine A.; McFarland, James M.; Stegmaier, Kimberly; Van Allen, Eliezer M. 分享 收藏
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