Richard F. Loeser - Publications, H-index & Citations

Richard F. Loeser

University of North Carolina at Chapel Hill

85H指数

423论文数

2.9W被引数

收录论文 175

发表时间

MDL-800-induced SIRT6 activation decreases age-associated osteoarthritis in mice MDL-800诱导的SIRT6激活降低小鼠年龄相关性骨关节炎

Arthritis & Rheumatology

IF10.9

2026-09-23

OAAI

Matheus Moreira Perez; Pranay Ramteke PhD; Bahiyah Watson; Owen Haslam; Eirene Choi; Susan Chubinskaya PhD; Mandy J. Peffers PhD; William R. Davis; Jacqueline Shine; Brian O. Diekman PhD; Richard F. Loeser MD; Theresa A. Freeman PhD; Makarand V. Risbud PhD; John A. Collins PhD

Comparative whole-genome analyses of articular chondrocytes and skin fibroblasts reveal distinct genome instability landscapes in mesenchymal cell types 比较关节软骨细胞和皮肤成纤维细胞的全基因组分析揭示间充质细胞类型中不同的基因组不稳定性景观

PLoS Genetics

IF3.7

2026-05-01

PREAI

Sauty, Safia Mahabub; Shine, Jacqueline; Bostan, Hamed; Li, Jian-Liang; Mieczkowski, Piotr A.; Loeser, Richard F.; Diekman, Brian O.; Gordenin, Dmitry A.

Osteoarthritic Synovial Fibroblasts Drive Inflammatory Responses and Impair Chondrocyte Function in Response to a Fibronectin Matrikine 骨关节炎滑膜成纤维细胞通过响应纤维连接蛋白基质肽驱动炎症反应并损害软骨细胞功能

Osteoarthritis and Cartilage

IF9

2026-04-20

OAAI

Jorge G. Fernandez Davila; Ralph A. Alberto; Seyoun Byun; Susan D’Costa; Jacqueline Shine; Carolina Alvarez; Adam B. Yanke; Christopher W. Olcott; Brian O. Diekman; Douglas H. Phanstiel; Richard F. Loeser

Screening of an FDA-approved drug library reveals MEK1/2 inhibitors block production of osteoarthritis mediators in activated human chondrocytes and synovial fibroblasts 对FDA批准的药物库进行筛选发现，MEK1/2抑制剂可阻断活化的人软骨细胞和滑膜成纤维细胞中骨关节炎介质的产生。

Osteoarthritis and Cartilage

IF9

2026-03-17

PREAI

Philip R. Coryell; Jorge G. Fernandez Davila; Adam B. Yanke; Kenneth H. Pearce; Richard F. Loeser

Sustained release of exogeneous fetuin-A from Hyaluronic acid microplates decreases joint degeneration, synovial hyperplasia and muscle damage in a murine post-traumatic osteoarthritis model 透明质酸微球中异源Fetuin-A的持续释放可降低小鼠创伤后骨关节炎模型中的关节退变、滑膜增生和肌肉损伤。

Arthritis Research & Therapy

IF4.6

2025-10-03

OAAI

Helen Willcockson; Antonietta Greco; Agnese Fragassi; Roberto Palomba; Kihyun Kwon; Huseyin Ozkan; Samuel T. Bartlett; Richard F. Loeser; Paolo Decuzzi; Lara Longobardi

Determining optimal diet/exercise treatment assignment for patients with symptomatic knee osteoarthritis using baseline gait forces 基于基线步态力的有症状膝关节骨关节炎患者最优饮食/运动治疗方案分配研究

OSTEOARTHRITIS AND CARTILAGE OPEN

IF2.8

2025-10-01

OAAI

Kostic, Aleksandra M.; Arbeeva, Liubov; Jiang, Xiaotong; Golightly, Yvonne M.; Messier, Stephen P.; Loeser, Richard F.; Borgert, J. E.; Marron, J. S.; Kosorok, Michael R.; Nelson, Amanda E.

Cross-sectional associations of radiographic multiple joint osteoarthritis and symptoms, laboratory values and the gut microbiota: A multimodal study in humans and pet dogs 放射学多关节骨关节炎的横断面关联及其与症状、实验室指标和肠道微生物群的关联：一项在人类和宠物犬中的多模式研究

OSTEOARTHRITIS AND CARTILAGE OPEN

IF2.8

2025-09-01

OAAI

Nelson, Amanda E.; Arbeeva, Liubov; Johnson, Kelly; Savage-Guin, Serena; Walker, Tessa; Enomoto, Masataka; Stevens, Christina; Koskinen, Milja; Cole, Tracey; Aker, Savannah; Thonen-Fleck, Connor; Azcarate-Peril, M. Andrea; Loeser, Richard F.; Renner, Jordan B.; Golightly, Yvonne M.; Lascelles, B. Duncan X.

Sirt6 deficiency promotes senescence and age-associated intervertebral disc degeneration in mice Sirt6 缺乏促进衰老和年龄相关的椎间盘退变在小鼠中

Bone Research

IF15

2025-05-08

OAAI

Pranay Ramteke; Bahiyah Watson; Mallory Toci; Victoria A. Tran; Shira Johnston; Maria Tsingas; Ruteja A. Barve; Ramkrishna Mitra; Richard F. Loeser; John A. Collins; Makarand V. Risbud

Secreted PD-L1 alleviates inflammatory arthritis in mice through local and systemic AAV gene therapy

FRONTIERS IN IMMUNOLOGY

IF5.9

2025-02-03

OAAI

Li, Wenjun; Sun, Junjiang; Feng, Susi; La Rosa, Ariana; Zhang, Panli; Wu, Eveline Y.; Loeser, Richard; Li, Chengwen

Disparities Between Rural and Urban Communities: Response to 18 Months of Diet and Exercise Versus Control for Knee Osteoarthritis and Overweight or Obesity

ARTHRITIS CARE & RESEARCH

IF3.3

2024-11-11

OAAI

Messier, Stephen P.; Monroe, Megan G.; Callahan, Leigh F.; Mihalko, Shannon L.; Beavers, Daniel P.; Queen, Kate; Miller, Gary D.; Losina, Elena; Katz, Jeffrey N.; Loeser, Richard F.; Devita, Paul; Hunter, David J.; Quandt, Sara A.

Integrin signalling in joint development, homeostasis and osteoarthritis (vol 20, pg 492, 2024)整合素信号在关节发育，稳态和骨关节炎中的作用 (第20卷，492页，2024)

NATURE REVIEWS RHEUMATOLOGY

IF32.7

2024-09-20

PREAI

Miao, Michael Z.; Lee, Janice S.; Yamada, Kenneth M.; Loeser, Richard F.

Association of Serum Biochemical Biomarker Profiles of Joint Tissue Inflammation and Cartilage Metabolism With Posttraumatic Osteoarthritis-Related Symptoms at 12 Months After ACLR

AMERICAN JOURNAL OF SPORTS MEDICINE

IF4.5

2024-08-11

PREAI

Lisee, Caroline; Obudzinski, Sarah; Pietrosimone, Brian G.; Creighton, R. Alexander; Kamath, Ganesh; Longobardi, Lara; Loeser, Richard; Schwartz, Todd A.; Spang, Jeffrey T.

Integrin signalling in joint development, homeostasis and osteoarthritis 整合素信号在关节发育，稳态和骨关节炎中的作用

NATURE REVIEWS RHEUMATOLOGY

IF32.7

2024-07-16

PREAI

Miao, Michael Z.; Lee, Janice S.; Yamada, Kenneth M.; Loeser, Richard F.

A NOVEL MATRIKINE STIMULATED EQUINE SYNOVIAL FIBROBLAST AND CHONDROCYTE COCULTURE MODEL OF OSTEOARTHRITIS: A PROPOSED ALTERNATIVE TO TRADITIONAL LPS AND IL-1B MODELS

OSTEOARTHRITIS AND CARTILAGE

IF9

2024-06-01

PREAI

Gagliardi, Rachel; Loeser, Richard F.; Schnabel, Lauren

Clinical phenotypes, molecular endotypes and theratypes in OA therapeutic development

NATURE REVIEWS RHEUMATOLOGY

IF32.7

2024-05-17

PREAI

Mobasheri, Ali; Loeser, Richard

Aging and the emerging role of cellular senescence in osteoarthritis

OSTEOARTHRITIS AND CARTILAGE

IF9

2024-04-01

PREAI

Diekman, Brian O.; Loeser, Richard F.

Cost-Effectiveness of Community-Based Diet and Exercise for Patients with Knee Osteoarthritis and Obesity or Overweight

ARTHRITIS CARE & RESEARCH

IF3.3

2024-03-22

PREAI

Kopp, Paul T.; Yang, Catherine; Yang, Heidi; Katz, Jeffrey N.; Paltiel, A. David; Hunter, David J.; Callahan, Leigh F.; Mihalko, Shannon L.; Newman, Jovita J.; Devita, Paul; Loeser, Richard F.; Miller, Gary D.; Messier, Stephen P.; Losina, Elena

DNA Damage and Cellular Senescence in Osteoarthritis: An Unexpected Role for Interferon Regulatory Factor 1 in Chondrocyte DNA Repair

ARTHRITIS & RHEUMATOLOGY

IF10.9

2024-02-27

PREAI

Diekman, Brian O.; Loeser, Richard F.

Clinical, Health-Related Quality of Life, and Gait Differences Among Obesity Classes in Adults With Knee Osteoarthritis

ARTHRITIS CARE & RESEARCH

IF3.3

2024-01-16

OAAI

Messier, Stephen P.; Gill, Malia E.; Mihalko, Shannon L.; Beavers, Daniel P.; Queen, Kate; Miller, Gary D.; Losina, Elena; Katz, Jeffrey N.; Loeser, Richard F.; Devita, Paul; Hunter, David J.; Quandt, Sara A.; Lyles, Mary F.; Hudson, David; Callahan, Leigh F.

Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritis

SCIENCE SIGNALING

IF6.6

2023-10-31

OAAI

Miao, Michael Z.; Su, Qian Peter; Cui, Yang; Bahnson, Edward M.; Li, Gang; Wang, Menglin; Yang, Yuchen; Collins, John A.; Wu, Di; Gu, Qisheng; Chubinskaya, Susan; Diekman, Brian O.; Yamada, Kenneth M.; Loeser, Richard F.

研究方向