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L

Li-Chuan Chan

university of texas system
H指数:30
被引数:7,836

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RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer

RNase1驱动的ALK激活是非小细胞肺癌中的致癌驱动因子和治疗靶点。

SIGNAL TRANSDUCTION AND TARGETED THERAPY
IF52.7
2025-04-180
OA
Zha, Zhengyu; Liu, Chunxiao; Yan, Meisi; Chen, Cong; Yu, Cheng; Chen, Yaohui; Zhou, Chenhao; Li, Lu; Li, Yi-Chuan; Yamaguchi, Hiro; Ye, Leiguang; Liu, Tong; Wang, Ying-Nai; Lee, Heng-Huan; Yang, Wen-Hao; Chan, Li-Chuan; Ke, Baozhen; Hsu, Jennifer L.; Ding, Lieming; Ji, Dong; Pan, Peng; Meng, Yiran; Pu, Yue; Hung, Mien-Chie
Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex
NATURE CANCER
IF28.5
2022-10-1713
OAAI
Chu, Yu-Yi; Chen, Mei-Kuang; Wei, Yongkun; Lee, Heng-Huan; Xia, Weiya; Wang, Ying-Nai; Yam, Clinton; Hsu, Jennifer L.; Wang, Hung-Ling; Chang, Wei-Chao; Yamaguchi, Hirohito; Jiang, Zhou; Liu, Chunxiao; Li, Ching-Fei; Nie, Lei; Chan, Li-Chuan; Gao, Yuan; Wang, Shao-Chun; Liu, Jinsong; Westin, Shannon N.; Lee, Sanghoon; Sood, Anil K.; Yang, Liuqing; Hortobagyi, Gabriel N.; Yu, Dihua; Hung, Mien-Chie
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer

ATR介导的CD47和PD-L1上调限制了结直肠癌放疗诱导的免疫启动和远位反应

SCIENCE IMMUNOLOGY
IF16.3
2022-06-2480
OA
Hsieh, Rodney Cheng-En; Krishnan, Sunil; Wu, Ren-Chin; Boda, Akash R.; Liu, Arthur; Winkler, Michelle; Hsu, Wen-Hao; Lin, Steven Hsesheng; Hung, Mien-Chie; Chan, Li-Chuan; Bhanu, Krithikaa Rajkumar; Srinivasamani, Anupallavi; De Azevedo, Ricardo Alexandre; Chou, Yung-Chih; DePinho, Ronald A.; Gubin, Matthew; Vilar, Eduardo; Chen, Chao Hsien; Slay, Ravaen; Jayaprakash, Priyamvada; Hegde, Shweta Mahendra; Hartley, Genevieve; Lea, Spencer T.; Prasad, Rishika; Morrow, Brittany; Couillault, Coline Agnes; Steiner, Madeline; Wang, Chun-Chieh; Venkatesulu, Bhanu Prasad; Taniguchi, Cullen; Kim, Yon Son Betty; Chen, Junjie; Rudqvist, Nils-Petter; Curran, Michael A.
Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer
JOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
2022-04-0116
OA
Cha, Jong-Ho; Chan, Li-Chuan; Wang, Ying-Nai; Chu, Yu-Yi; Wang, Chie-Hong; Lee, Heng-Huan; Xia, Weiya; Shyu, Woei-Cherng; Liu, Shih-Ping; Yao, Jun; Chang, Chiung-Wen; Cheng, Fan-Ru; Liu, Jielin; Lim, Seung-Oe; Hsu, Jennifer L.; Yang, Wen-Hao; Hortobagyi, Gabriel N.; Lin, Chunru; Yang, Liuqing; Yu, Dihua; Jeng, Long-Bin; Hung, Mien-Chie
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
NATURE COMMUNICATIONS
IF15.7
2021-05-1320
OAAI
Lee, Heng-Huan; Wang, Ying-Nai; Yang, Wen-Hao; Xia, Weiya; Wei, Yongkun; Chan, Li-Chuan; Wang, Yu-Han; Jiang, Zhou; Xu, Shouping; Yao, Jun; Qiu, Yufan; Hsu, Yi-Hsin; Hwang, Wei-Lun; Yan, Meisi; Cha, Jong-Ho; Hsu, Jennifer L.; Shen, Jia; Ye, Yuanqing; Wu, Xifeng; Hou, Ming-Feng; Tseng, Lin-Ming; Wang, Shao-Chun; Pan, Mei-Ren; Yang, Chin-Hua; Wang, Yuan-Liang; Yamaguchi, Hirohito; Pang, Da; Hortobagyi, Gabriel N.; Yu, Dihua; Hung, Mien-Chie
Targeting glycosylated PD-1 induces potent anti-tumor immunity
CANCER RESEARCH
IF16.6
2020-08-151
PRE
Wang, Yuhan; Sun, Linlin; Yang, Riyao; Liu, Jielin; Qiu, Yufan; Hsu, Jennifer L.; Cha, Jong-ho; Chan, Li-Chuan; Hsu, Jung-Mao; Lee, Heng-Huan; Lai, Yun-Ju; Khoo, Kay-Hooi; Chung, Ezra M.; Li, Chia-Wei; Kim, Yong-Soo; Park, Andrew H.; Yang, Yi; Yoo, Stephen S.; Hung, Mien-Chie
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
CANCER RESEARCH
IF16.6
2020-06-02115
OAAI
Sun, Linlin; Li, Chia-Wei; Chung, Ezra M.; Yang, Riyao; Kim, Yong-Soo; Park, Andrew H.; Lai, Yun-Ju; Yang, Yi; Wang, Yu-Han; Liu, Jielin; Qiu, Yufan; Khoo, Kay-Hooi; Yao, Jun; Hsu, Jennifer L.; Cha, Jong-Ho; Chan, Li-Chuan; Hsu, Jung-Mao; Lee, Heng-Huan; Yoo, Stephen S.; Hung, Mien-Chie
CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer (vol 10, 5114, 2019)
NATURE COMMUNICATIONS
IF15.7
2020-01-292
OAAI
Nie, Lei; Wei, Yongkun; Zhang, Fei; Hsu, Yi-Hsin; Chan, Li-Chuan; Xia, Weiya; Ke, Baozhen; Zhu, Cihui; Deng, Rong; Tang, Jun; Yao, Jun; Chu, Yu-Yi; Zhao, Xixi; Han, Ye; Hou, Junwei; Huo, Longfei; Ko, How-Wen; Lin, Wan-Chi; Yamaguchi, Hirohito; Hsu, Jung-Mao; Yang, Yi; Pan, Dean N.; Hsu, Jennifer L.; Kleer, Celina G.; Davidson, Nancy E.; Hortobagyi, Gabriel N.; Hung, Mien-Chie
CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer
NATURE COMMUNICATIONS
IF15.7
2019-11-0875
OAAI
Nie, Lei; Wei, Yongkun; Zhang, Fei; Hsu, Yi-Hsin; Chan, Li-Chuan; Xia, Weiya; Ke, Baozhen; Zhu, Cihui; Deng, Rong; Tang, Jun; Yao, Jun; Chu, Yu-Yi; Zhao, Xixi; Han, Ye; Hou, Junwei; Huo, Longfei; Ko, How-Wen; Lin, Wan-Chi; Yamaguchi, Hirohito; Hsu, Jung-Mao; Yang, Yi; Pan, Dean N.; Hsu, Jennifer L.; Kleer, Celina G.; Davidson, Nancy E.; Hortobagyi, Gabriel N.; Hung, Mien-Chie
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2019-07-15266
OA
Chan, Li-Chuan; Li, Chia-Wei; Xia, Weiya; Hsu, Jung-Mao; Lee, Heng-Huan; Cha, Jong-Ho; Wang, Hung-Ling; Yang, Wen-Hao; Yen, Er-Yen; Chang, Wei-Chao; Zha, Zhengyu; Lim, Seung-Oe; Lai, Yun-Ju; Liu, Chunxiao; Liu, Jielin; Dong, Qiongzhu; Yang, Yi; Sun, Linlin; Wei, Yongkun; Nie, Lei; Hsu, Jennifer L.; Li, Hui; Ye, Qinghai; Hassan, Manal M.; Amin, Hesham M.; Kaseb, Ahmed O.; Lin, Xin; Wang, Shao-Chun; Hung, Mien-Chie
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression
NATURE IMMUNOLOGY
IF27.6
2019-06-03265
OAAI
Hu, Qingsong; Ye, Youqiong; Chan, Li-Chuan; Li, Yajuan; Liang, Ke; Lin, Aifu; Egranov, Sergey D.; Zhang, Yaohua; Xia, Weiya; Gong, Jing; Pan, Yinghong; Chatterjee, Sujash S.; Yao, Jun; Evans, Kurt W.; Nguyen, Tina K.; Park, Peter K.; Liu, Jiewei; Coarfa, Cristian; Donepudi, Sri Ramya; Putluri, Vasanta; Putluri, Nagireddy; Sreekumar, Arun; Ambati, Chandrashekar R.; Hawke, David H.; Marks, Jeffrey R.; Gunaratne, Preethi H.; Caudle, Abigail S.; Sahin, Aysegul A.; Hortobagyi, Gabriel N.; Meric-Bernstam, Funda; Chen, Lieping; Yu, Dihua; Hung, Mien-Chie; Curran, Michael A.; Han, Leng; Lin, Chunru; Yang, Liuqing

研究方向

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M
Mien‐Chie Hung
H 指数:163论文数:1,535被引数:9.9万
J
Jennifer L. Hsu
H 指数:39论文数:191被引数:1.1万
W
Weiya Xia
H 指数:73论文数:381被引数:3.0万
H
Heng‐Huan Lee
H 指数:32论文数:127被引数:7,853
J
Jong‐Ho Cha
H 指数:34论文数:118被引数:8,259
J
Jung-Mao Hsu
H 指数:45论文数:144被引数:1.3万
Y
Yongkun Wei
H 指数:49论文数:194被引数:1.4万
G
Gabriel N. Hortobágyi
H 指数:187论文数:1,906被引数:13.9万
Jun Yao 封面图
Jun Yao
H 指数:57论文数:238被引数:1.7万
Dihua Yu 封面图
Dihua Yu
H 指数:85论文数:553被引数:2.9万