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Novel bispecific molecules combining HERA-CD40L with anti-CEA or with anti-PD-L1 for targeting Thiemann, Meinolf; Billian-Frey, Katharina; Schroeder, Matthias; Merz, Christian; Sykora, Jaromir; Richards, David M.; Mueller, Mauricio Redondo; Sefrin, Julian P.; Heinonen, Karl; Gieffers, Christian; Hill, Oliver 分享 收藏
Hexavalent HERA-CD40L induces a productive T cell-mediated anti-tumor immune response and shows superior activity in comparison to benchmark CD40 agonistic antibodies Gieffers, Christian; Richards, David M.; Sykora, Jaromir; Merz, Christian; Sefrin, Julian P.; Billian-Frey, Katharina; Heinonen, Karl; Mueller, Mauricio Redondo; Schroeder, Matthias; Thiemann, Meinolf; Hill, Oliver 分享 收藏
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HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality Herra-gitrl激活T细胞并促进抗肿瘤功效,而与fc γ r结合功能无关 Richards, David M.; Marschall, Viola; Billian-Frey, Katharina; Heinonen, Karl; Merz, Christian; Mueller, Mauricio Redondo; Sefrin, Julian P.; Schroeder, Matthias; Sykora, Jaromir; Fricke, Harald; Hill, Oliver; Gieffers, Christian; Thiemann, Meinolf 分享 收藏
The novel hexavalent human GITR agonist HERA-GITRL promotes anti-tumor efficacy independent of Fc-functionality and shows superior activity compared with the monoclonal anti-GITR antibody TRX518 Schroeder, Matthias; Marshall, Viola; Thiemann, Meinolf; Richards, David M.; Merz, Christian; Sykora, Jaromir; Sefrin, Julian P.; Redondo-Mueller, Mauricio; Heinonen, Karl; Billian-Frey, Katharina; Hill, Oliver; Gieffers, Christian 分享 收藏
HERA-CD40L a hexavalent CD40 agonist induces T cell mediated antitumor immune response and shows superior activity in direct comparison to benchmark agonistic antibodies Gieffers, Christian; Sykora, Jaromir; Merz, Christian; Muller, Mauricio Redondo; Richards, David M.; Sefrin, Julian; Billian-Frey, Katharina; Heinonen, Karl; Marschall, Viola; Schroder, Matthias; Fricke, Harald; Thiemann, Meinolf; Oliver, Hill 分享 收藏
HERA-CD27L, a true CD27 agonist, is a hexavalent CD27 ligand that enhances T cell activation and induces potent anti-tumor immunity Sefrin, Julian P.; Richards, David M.; Billian-Frey, Katharina; Heinonen, Karl; Marschall, Viola; Merz, Christian; Mueller, Mauricio Redondo; Schroeder, Matthias; Sykora, Jaromir; Thiemann, Meinolf; Fricke, Harald; Gieffers, Christian; Hill, Oliver 分享 收藏
The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell-mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells 六价CD40激动剂HERA-CD40L通过激活抗原呈递细胞诱导T细胞介导的抗肿瘤免疫反应 Merz, Christian; Sykora, Jaromir; Marschall, Viola; Richards, David M.; Heinonen, Karl; Mueller, Mauricio Redondo; Thiemann, Meinolf; Schnyder, Tim; Fricke, Harald; Hill, Oliver; Gieffers, Christian 分享 收藏
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity Thiemann, Meinolf; Richards, David M.; Heinonen, Karl; Kluge, Michael; Marschall, Viola; Merz, Christian; Muller, Mauricio Redondo; Schnyder, Tim; Sefrin, Julian P.; Sykora, Jaromir; Fricke, Harald; Gieffers, Christian; Hill, Oliver 分享 收藏
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The novel hexavalent human CD137/4-1BB agonist HERA-CD137L promotes anti-cancer immunity by activating CD8 T cells while regulatory T cells are not affected Thiemann, Meinolf; Sykora, Jaromir; Richards, David M.; Merz, Christian; Marschall, Viola; Mueller, Mauricio Redondo; Sefrin, Julian P.; Heinonen, Karl; Fricke, Harald; Gieffers, Christian; Hill, Oliver 分享 收藏
Novel hexavalent HVEM agonist HERA-LIGHT promotes T cell activation and expansion Sefrin, Julian P.; Richards, David M.; Sykora, Jaromir; Thiemann, Meinolf; Merz, Christian; Marschall, Viola; Mueller, Mauricio Redondo; Heinonen, Karl; Fricke, Harald; Gieffers, Christian; Hill, Oliver 分享 收藏
Hexavalent CD27 agonists show single agent anti-tumor activity and enhanced memory formation in mouse syngeneic tumor models Gieffers, Christian; Richards, David; Sykora, Jaromir; Redondo-Muller, Mauricio; Thiemann, Meinolf; Merz, Christian; Heinonen, Karl Heinonen; Marschall, Viola; Fricke, Harald; Hill, Oliver 分享 收藏
Novel hexavalent GITR agonists stimulate T cells and enhance memory formation Thiemann, Meinolf; Gieffers, Christian; Richards, David M.; Merz, Christian; Heinonen, Karl; Mueller, Mauricio Redondo; Marschall, Viola; Sykora, Jaromir; Fricke, Harald; Hill, Oliver 分享 收藏
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