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I

Isaac Cohen

University of California System
H指数:37
被引数:4,460

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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

实验性eIF2B激活剂DNL343在TDP-43病理学的临床前模型和随机临床试验中的ALS患者中调节整合应激反应

Nature Communications
IF15.7
2025-08-180
OAAI
Brittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock
Precision medicine integrating whole-genome sequencing, comprehensive metabolomics, and advanced imaging

整合全基因组测序、综合代谢组学和高级成像的精准医学

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2020-01-2479
OAAI
Hou, Ying-Chen Claire; Yu, Hung-Chun; Martin, Rick; Cirulli, Elizabeth T.; Schenker-Ahmed, Natalie M.; Hicks, Michael; Cohen, Isaac V.; Jonsson, Thomas J.; Heister, Robyn; Napier, Lori; Swisher, Christine Leon; Dominguez, Saints; Tang, Haibao; Li, Weizhong; Perkins, Bradley A.; Barea, Jaime; Rybak, Christina; Smith, Emily; Duchicela, Keegan; Doney, Michael; Brar, Pamila; Hernandez, Nathaniel; Kirkness, Ewen F.; Kahn, Andrew M.; Venter, J. Craig; Karow, David S.; Caskey, C. Thomas
An unsupervised learning approach to identify novel signatures of health and disease from multimodal data
GENOME MEDICINE
IF11.2
2020-01-1032
OAAI
Shomorony, Ilan; Cirulli, Elizabeth T.; Huang, Lei; Napier, Lori A.; Heister, Robyn R.; Hicks, Michael; Cohen, Isaac V.; Yu, Hung-Chun; Swisher, Christine Leon; Schenker-Ahmed, Natalie M.; Li, Weizhong; Nelson, Karen E.; Brar, Pamila; Kahn, Andrew M.; Spector, Timothy D.; Caskey, C. Thomas; Venter, J. Craig; Karow, David S.; Kirkness, Ewen F.; Shah, Naisha

研究方向

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