未登录 Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration Dong, Shuzhi; Zhao, Zhiqiang; Tang, Haiqun; Li, Guoqing; Pan, Jianping; Gu, Xin; Jiang, Jinlong; Xiao, Li; Scapin, Giovanna; Hunter, David N.; Yang, Dexi; Huang, Yuhua; Bennett, Frank; Yang, Shu-Wei; Mandal, Mihirbaran; Tang, Haifeng; Su, Jing; Tudge, Clare; Dejesus, Reynalda Keh; Ding, Fa-Xiang; Lombardo, Matthew; Hicks, Jacqueline D.; Fischmann, Thierry; Mirza, Asra; Dayananth, Priya; Painter, Ronald E.; Villafania, Artjohn; Garlisi, Charles G.; Zhang, Rumin; Mayhood, Todd W.; Si, Qian; Li, Nianyu; Amin, Rupesh P.; Bhatt, Bhavana; Chen, Feifei; Regan, Christopher P.; Regan, Hillary; Lin, Xinjie; Wu, Jin; Leithead, Andrew; Pollack, Scott R.; Scott, Jack D.; Nargund, Ravi P.; Therien, Alex G.; Black, Todd; Young, Katherine; Pasternak, Alexander 分享 收藏
Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies Dang, Xibei; Guelen, Lars; Hulsik, David Lutje; Ermakov, Grigori; Hsieh, Edward J.; Kreijtz, Joost; Stammen-Vogelzangs, Judith; Lodewijks, Imke; Bertens, Astrid; Bramer, Arne; Guadagnoli, Marco; Nazabal, Alexis; van Elsas, Andrea; Fischmann, Thierry; Juan, Veronica; Beebe, Amy; Beaumont, Maribel; van Eenennaam, Hans 分享 收藏
Structural insights into selective small molecule activation of PKG1α Metwally, Essam; Mak, Victor; Soriano, Aileen; Zebisch, Matthias; Silvestre, H. Leonardo; McEwan, Paul A.; Ermakov, Grigori; Beaumont, Maribel; Tawa, Paul; Barker, John J.; Yen, Rose; Patel, Akash; Lim, Yeon-Hee; Healy, David; Hanisak, Jennifer; Cheng, Alan C.; Greshock, Tom; Fischmann, Thierry O. 分享 收藏
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases Kleiner, Victoria A.; Fischmann, Thierry O.; Howe, John A.; Beshore, Douglas C.; Eddins, Michael J.; Hou, Yan; Mayhood, Todd; Klein, Daniel; Nahas, Debbie D.; Lucas, Bob J.; Xi, He; Murray, Edward; Ma, Daphne Y.; Getty, Krista; Fearns, Rachel 分享 收藏
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta- Lactamase Inhibitors: Initial Leads toward Clinical Candidates Mandal, Mihirbaran; Xiao, Li; Pan, Weidong; Scapin, Giovanna; Li, Guoqing; Tang, Haiqun; Yang, Shu-Wei; Pan, Jianping; Root, Yuriko; de Jesus, Reynalda Keh; Yang, Christine; Prosise, Winnie; Dayananth, Priya; Mirza, Asra; Therien, Alex G.; Young, Katherine; Flattery, Amy; Garlisi, Charles; Zhang, Rumin; Chu, Donald; Sheth, Payal; Chu, Inhou; Wu, Jin; Markgraf, Carrie; Kim, Hai-Young; Painter, Ronald; Mayhood, Todd W.; DiNunzio, Edward; Wyss, Daniel F.; Buevich, Alexei, V; Fischmann, Thierry; Pasternak, Alexander; Dong, Shuzhi; Hicks, Jacqueline D.; Villafania, Artjohn; Liang, Lianzhu; Murgolo, Nicholas; Black, Todd; Hagmann, William K.; Tata, Jim; Parmee, Emma R.; Weber, Ann E.; Su, Jing; Tang, Haifeng 分享 收藏
Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α Mak, Victor W.; Patel, Akash M.; Yen, Rose; Hanisak, Jennifer; Lim, Yeon-Hee; Bao, Jianming; Zheng, Rong; Seganish, W. Michael; Yu, Yang; Healy, David R.; Ogawa, Aimie; Ren, Zhao; Soriano, Aileen; Ermakov, Grigori P.; Beaumont, Maribel; Metwally, Essam; Cheng, Alan C.; Verras, Andreas; Fischmann, Thierry; Zebisch, Matthias; Silvestre, H. Leonardo; McEwan, Paul A.; Barker, John; Rearden, Paul; Greshock, Thomas J. 分享 收藏
Characterization and Modeling of Reversible Antibody Self-Association Provide Insights into Behavior, Prediction, and Correction Mieczkowski, Carl; Cheng, Alan; Fischmann, Thierry; Hsieh, Mark; Baker, Jeanne; Uchida, Makiko; Raghunathan, Gopalan; Strickland, Corey; Fayadat-Dilman, Laurence 分享 收藏
Pembrolizumab microgravity crystallization experimentation Pembrolizumab微重力结晶实验 Reichert, Paul; Prosise, Winifred; Fischmann, Thierry O.; Scapin, Giovanna; Narasimhan, Chakravarthy; Spinale, April; Polniak, Ray; Yang, Xiaoyu; Walsh, Erika; Patel, Daya; Benjamin, Wendy; Welch, Johnathan; Simmons, Denarra; Strickland, Corey 分享 收藏
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability Methot, Joey L.; Zhou, Hua; Kattar, Sam D.; McGowan, Meredeth A.; Wilson, Kevin; Garcia, Yudith; Deng, Yongi; Altman, Michael; Fradera, Xavier; Lesburg, Charles; Fischmann, Thierry; Li, Chaomin; Alves, Steve; Shah, Sanjiv; Fernandez, Rafael; Goldenblatt, Peter; Hill, Armetta; Shaffer, Lynsey; Chen, Dapeng; Tong, Vince; McLeod, Robbie L.; Yu, Hongshi; Bass, Alan; Kemper, Ray; Gatto, Nicholas T.; LaFranco-Scheuch, Lisa; Trotter, Benjamin Wesley; Guzi, Timothy; Katz, Jason D. 分享 收藏
Discovery of Selective RNA-Binding Small Molecules by Affinity Selection Mass Spectrometry Rizvi, Noreen F.; Howe, John A.; Nahvi, Ali; Klein, Daniel J.; Fischmann, Thierry O.; Kim, Hai-Young; McCoy, Mark A.; Walker, Scott S.; Hruza, Alan; Richards, Matthew P.; Chamberlin, Chad; Saradjian, Peter; Butko, Margaret T.; Mercado, Gabriel; Burchard, Julja; Strickland, Corey; Dandliker, Peter J.; Smith, Graham F.; Nickbarg, Elliott B. 分享 收藏
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Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets Mann, Paul A.; Mueller, Anna; Wolff, Kerstin A.; Fischmann, Thierry; Wang, Hao; Reed, Patricia; Hou, Yan; Li, Wenjin; Mueller, Christa E.; Xiao, Jianying; Murgolo, Nicholas; Sher, Xinwei; Mayhood, Todd; Sheth, Payal R.; Mirza, Asra; Labroli, Marc; Xiao, Li; McCoy, Mark; Gill, Charles J.; Pinho, Mariana G.; Schneider, Tanja; Roemer, Terry 分享 收藏
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis Liu, Jian; Guiadeen, Deodial; Krikorian, Arto; Gao, Xiaolei; Wang, James; Boga, Sobhana Babu; Alhassan, Abdul-Basit; Yu, Younong; Vaccaro, Henry; Liu, Shilan; Yang, Chundao; Wu, Hao; Cooper, Alan; de Man, Jos; Kaptein, Allard; Maloney, Kevin; Hornak, Viktor; Gao, Ying-Duo; Fischmann, Thierry O.; Raaijmakers, Hans; Vu-Pham, Diep; Presland, Jeremy; Mansueto, My; Xu, Zangwei; Leccese, Erica; Zhang-Hoover, Jie; Knemeyer, Ian; Garlisi, Charles G.; Bays, Nathan; Stivers, Peter; Brandish, Philip E.; Hicks, Alexandra; Kim, Ronald; Kozlowskit, Joseph A. 分享 收藏
Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors 2，6-二氨基嘧啶-4-酮IRAK4抑制剂的发现和结构使合成成为可能 Seganish, W. Michael; Fischmann, Thierry O. .; Sherborne, Brad; Matasi, Julius; Lavey, Brian; McElroy, William T.; Tulshian, Deen; Tata, James; Sondey, Christopher; Garlisi, Charles G.; Devito, Kristine; Fossetta, James; Lundell, Daniel; Niu, Xiaoda 分享 收藏
Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation McElroy, William T.; Tan, Zheng; Ho, Ginny; Paliwal, Sunil; Li, Guoqing; Seganish, W. Michael; Tulshian, Deen; Tata, James; Fischmann, Thierry O.; Sondey, Christopher; Bian, Hong; Bober, Loretta; Jackson, James; Garlisi, Charles G.; Devito, Kristine; Fossetta, James; Lundell, Daniel; Niu, Xiaoda 分享 收藏
Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4 IRAK4的5-氨基-n-(1h-吡唑-4-基) 吡唑并 [1，5-a]pyrimidine-3-carboxamide抑制剂的发现 Lim, Jongwon; Altman, Michael D.; Baker, James; Brubaker, Jason D.; Chen, Hongmin; Chen, Yiping; Fischmann, Thierry; Gibeau, Craig; Kleinschek, Melanie A.; Leccese, Erica; Lesburg, Charles; Maclean, John K. F.; Moy, Lily Y.; Mulrooney, Erin F.; Presland, Jeremy; Rakhilina, Larissa; Smith, Graham F.; Steinhuebel, Dietrich; Yang, Ruojing 分享 收藏
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Modulating the interaction between cdk2 and cyclin A: Screening, synthesis and characterization of a quinoline-based inhibitor Windsor, William T.; Deng, Yongqi; Shipps, Gerald W.; Zhao, Lianyun; Siddiqui, Arshad; Popovici-Muller, Janeta; Curran, Patrick; Fischmann, Thierry; Duca, Jose S.; Hruza, Alan; Zhang, Rumin; McNemar, Charles; Mayhood, Todd; Syto, Rosalinda; Parry, David A.; Lees, Emma; Kirschmeier, Paul 分享 收藏
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Dinaciclib (SCH 727965), a Novel and Potent Cyclin-Dependent Kinase Inhibitor Parry, David; Guzi, Timothy; Shanahan, Frances; Davis, Nicole; Prabhavalkar, Deepa; Wiswell, Derek; Seghezzi, Wolfgang; Paruch, Kamil; Dwyer, Michael P.; Doll, Ronald; Nomeir, Amin; Windsor, William; Fischmann, Thierry; Wang, Yaolin; Oft, Martin; Chen, Taiying; Kirschmeier, Paul; Lees, Emma M. 分享 收藏
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