Richard J. Heath

Barbara Ann Karmanos Cancer Institute

H指数:40

被引数:7,444

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Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design

苯基二氢尿嘧啶: 用于PROTAC设计的替代cerebon粘合剂

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2023-01-0433

The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model

CANCER RESEARCH

IF16.6

2021-02-2610

Mechanisms of NT5C2-Mediated Thiopurine Resistance in Acute Lymphoblastic Leukemia

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-10-0119

OAAI

Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance

与REV1的泛素结合基序结合的小分子抑制REV1与K164-monoubiquitinated PCNA的相互作用并抑制DNA损伤耐受性

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2018-05-0120

OAAI

Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo

MBIO

IF4.7

2016-12-3039

OAAI

Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2016-09-0138

OAAI

A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

DNA复制辅助因子增殖细胞核抗原 (PCNA) 的位点选择性，不可逆抑制剂

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2014-11-0120

OAAI

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin

单核增殖细胞核抗原 (PCNA) 的小分子抑制剂抑制链间DNA交联的修复，增强DNA双链断裂，并使癌细胞对顺铂敏感

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-03-0187

OAAI

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid-CbpA Peptide Recombinant Fusion Protein

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2013-09-1673

OAAI

Crystal Structure of the Avian Astrovirus Capsid Spike

JOURNAL OF VIROLOGY

IF3.8

2013-07-1541

OAAI

Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-04-01132

OAAI

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity

PLOS PATHOGENS

IF4.9

2011-12-01118

OAAI

Collagen stabilization and modification using a polyepoxide, triglycidyl isocyanurate

POLYMER DEGRADATION AND STABILITY

IF7.4

2009-10-0156

PREAI

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae

EMBO JOURNAL

IF8.3

2004-12-1694

OAAI

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK)

BIOCHEMICAL JOURNAL

IF4.3

2003-03-15134

OAAI

The Claisen condensation in biology

NATURAL PRODUCT REPORTS

IF10.6

2002-07-11241

PREAI

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

IF4.3

2002-05-01197

PREAI

Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2002-02-0150

OAAI

Lipid biosynthesis as a target for antibacterial agents

PROGRESS IN LIPID RESEARCH

IF14.9

2001-11-01344

PREAI

Bacterial fatty-acid biosynthesis: an antibacterial drug target waiting to be exploited

DRUG DISCOVERY TODAY

IF7.5

2001-07-0117

PREAI

Richard J. Heath

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