Kian‐Huat Lim - Publications, H-index & Citations

Kian‐Huat Lim

Washington University School of Medicine

40H指数

278论文数

9.7K被引数

收录论文 56

发表时间

Acquired resistance to the RAS(ON) multi-selective inhibitor daraxonrasib guides rational combination therapy strategies in pancreatic cancer 对RAS(ON) 多选择性抑制剂daraxonrasib的获得性耐药性指导胰腺癌的合理联合治疗策略

Nature Medicine

IF50

2026-08-11

OAAI

Ida Aronchik; Sumit Kar; Yongxian Zhuang; Ethan Ahler; Lick Pui Lai; Vidya Seshadri; Yu Chi Yang; Ashenafi Bulle; Marie Menard; Biswadeep Nayak; Mark P. Labrecque; Julien Dilly; Eejung Kim; Lingyan Jiang; Jason Yano; Urszula N. Wasko; Ciara Helland; Sean Bredeson; Brett Garrick; Yevgeniy Gindin; Brad Sickler; Xing Wei; Kyle Seamon; Jingjing Jiang; Kian-Huat Lim; Matthew Holderfield; Elsa Quintana; Aparna Hegde; Zeena Salman; Alexander Starodub; Alexander Spira; Wungki Park; David S. Hong; Minal Barve; Meredith Pelster; David Sommerhalder; Salman R. Punekar; Ignacio Garrido-Laguna; Brian M. Wolpin; Anirban Maitra; W. Clay Gustafson; Steve Kelsey; Jacqueline A. M. Smith; Kevin K. Lin; Andrew J. Aguirre; Mallika Singh

Blockade of Tumor TAK1 Induces DNA Damage and Immunogenic cGAS-STING Pathway Activation in Pancreatic Cancer 抑制肿瘤TAK1诱导胰腺癌中DNA损伤和免疫原性cGAS-STING通路激活

Gastroenterology

IF25.1

2026-05-01

OAAI

Sapana P. Bansod; Timothy Hung-Po Chen; Vikas K. Somani; Lin Li; Yutong Geng; Yu Wang; Ashenafi Bulle; Suneeta Modekurty; Brett L. Knolhoff; Ryan C. Fields; Marianna B. Ruzinova; David G. DeNardo; Kian-Huat Lim

Meeting Report From the 2024 Symposium on IRAK4 in Cancer: Highlights and Clinical Updates 会议报告：2024年癌症领域IRAK4专题研讨会——要点与临床更新

Clinical Lymphoma Myeloma and Leukemia

IF2.7

2025-05-30

OAAI

Eric S. Winer; Marina Konopleva; Han W. Tun; Kian-Huat Lim; Bently Doonan; Klaus H. Metzeler; Lakshmi Nayak; Andrés J.M. Ferreri; Christina von Roemeling; Grzegorz S. Nowakowski; Guillermo Garcia-Manero

Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy 基质重编程克服了对ras-mapk抑制的抵抗力，从而改善了胰腺癌对细胞毒性和免疫治疗的反应

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-10-23

PREAI

Liu, Xiuting; Baer, John M.; Stone, Meredith L.; Knolhoff, Brett L.; Hogg, Graham D.; Turner, Madeleine C.; Kao, Yu-Lan; Weinstein, Alyssa G.; Ahmad, Faiz; Chen, Jie; Schmidt, Andrew D.; Klomp, Jeffrey A.; Coho, Heather; Coho, Kayjana S.; Coma, Silvia; Pachter, Jonathan A.; Bryant, Kirsten L.; Kang, Liang-, I; Lim, Kian-Huat; Beatty, Gregory L.; DeNardo, David G.

Antisense Oligonucleotide STK-002 Increases OPA1 in Retina and Improves Mitochondrial Function in Autosomal Dominant Optic Atrophy Cells

NUCLEIC ACID THERAPEUTICS

IF4.7

2024-10-01

PREAI

Venkatesh, Aditya; McKenty, Taylor; Ali, Syed; Sonntag, Donna; Ravipaty, Shobha; Cui, Yanyan; Slate, Deirdre; Lin, Qian; Christiansen, Anne; Jacobson, Sarah; Kach, Jacob; Lim, Kian Huat; Srinivasan, Vaishnavi; Zinshteyn, Boris; Aznarez, Isabel; Huryn, Laryssa A.; Li, Zhiyu; Hufnagel, Robert B.; Liau, Gene; Anderson, Karen; Hoger, Jeff

The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS

CELL REPORTS

IF6.9

2024-09-01

OAAI

Bansod, Sapana; Dodhiawala, Paarth B.; Geng, Yutong; Bulle, Ashenafi; Liu, Peng; Li, Lin; Townsend, Reid; Grierson, Patrick M.; Held, Jason M.; Adhikari, Hema; Lim, Kian-Huat

Epacadostat with preoperative chemoradiation in locally advanced rectal cancer (LARC): Results of a translational phase I clinical trial

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Park, Haeseong; Pedersen, Katrina; Huang, Katherine; Mutch, Matthew; Kim, Hyun; Trikalinos, Nikolaos; Aranha, Olivia; Tan, Benjamin; Suresh, Rama; Ratner, Lee; Khushman, Moh'd; Visconti, John; Lim, Kian-Huat; Henke, Lauren; Swiecicki, Maddie; Liu, Jingxia; Parikh, Parag; Ciorba, Matthew

Combined inhibition of RAF, MEK and FAK increases PDAC responsiveness to cytotoxic- and immune therapy

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Liu, Xiuting; Baer, John; Knolhoff, Brett; Hogg, Graham; Ahmad, Faiz; Coma, Silvia; Pachter, Jonathan; Lim, Kian; DeNardo, David

Combined KRAS-MAPK pathway inhibitors and HER2-directed drug conjugate is efficacious in pancreatic cancer 联合kras-mapk通路抑制剂和HER2-directed药物偶联物对胰腺癌有效

NATURE COMMUNICATIONS

IF15.7

2024-03-20

OAAI

Bulle, Ashenafi; Liu, Peng; Seehra, Kuljeet; Bansod, Sapana; Chen, Yali; Zahra, Kiran; Somani, Vikas; Khawar, Iftikhar Ali; Chen, Hung-Po; Dodhiawala, Paarth B.; Li, Lin; Geng, Yutong; Mo, Chia-Kuei; Mahsl, Jay; Ding, Li; Govindan, Ramaswamy; Davies, Sherri; Mudd, Jacqueline; Hawkins, William G.; Fields, Ryan C.; Denardo, David G.; Knoerzer, Deborah; Held, Jason M.; Grierson, Patrick M.; Wang-Gillam, Andrea; Ruzinova, Marianna B.; Lim, Kian-Huat

High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival

NPJ PRECISION ONCOLOGY

IF8

2023-10-19

OAAI

Storrs, Erik P.; Chati, Prathamesh; Usmani, Abul; Sloan, Ian; Krasnick, Bradley A.; Babbra, Ramandeep; Harris, Peter K.; Sachs, Chloe M.; Qaium, Faridi; Chatterjee, Deyali; Wetzel, Chris; Goedegebuure, S. Peter; Hollander, Thomas; Anthony, Hephzibah; Ponce, Jennifer; Khaliq, Ateeq M.; Badiyan, Shahed; Kim, Hyun; Denardo, David G.; Lang, Gabriel D.; Cosgrove, Natalie D.; Kushnir, Vladimir M.; Early, Dayna S.; Masood, Ashiq; Lim, Kian-Huat; Hawkins, William G.; Ding, Li; Fields, Ryan C.; Das, Koushik K.; Chaudhuri, Aadel A.

Combining the Tyrosine Kinase Inhibitor Cabozantinib and the mTORC1/2 Inhibitor Sapanisertib Blocks ERK Pathway Activity and Suppresses Tumor Growth in Renal Cell Carcinoma

CANCER RESEARCH

IF16.6

2023-09-27

OAAI

Wu, Yige; Chen, Siqi; Yang, Xiaolu; Sato, Kazuhito; Lal, Preet; Wang, Yuefan; Shinkle, Andrew T.; Wendl, Michael C.; Primeau, Tina M.; Zhao, Yanyan; Gould, Alanna; Sun, Hua; Mudd, Jacqueline L.; Hoog, Jeremy; Mashl, R. Jay; Wyczalkowski, Matthew A.; Mo, Chia-Kuei; Liu, Ruiyang; Herndon, John M.; Davies, Sherri R.; Liu, Di; Ding, Xi; Evrard, Yvonne A.; Welm, Bryan E.; Lum, David; Koh, Mei Yee; Welm, Alana L.; Chuang, Jeffrey H.; Moscow, Jeffrey A.; Meric-Bernstam, Funda; Govindan, Ramaswamy; Li, Shunqiang; Hsieh, James; Fields, Ryan C.; Lim, Kian-Huat; Ma, Cynthia X.; Zhang, Hui; Ding, Li; Chen, Feng

Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study

CANCER & METABOLISM

IF5.3

2023-05-18

OAAI

Park, Lauren K.; Lim, Kian-Huat; Volkman, Jonas; Abdiannia, Mina; Johnston, Hannah; Nigogosyan, Zack; Siegel, Marilyn J.; McGill, Janet B.; McKee, Alexis M.; Salam, Maamoun; Zhang, Rong M.; Ma, Da; Popuri, Karteek; Chow, Vincent Tze Yang; Beg, Mirza Faisal; Hawkins, William G.; Peterson, Linda R.; Ippolito, Joseph E.

Stromal and therapy-induced macrophage proliferation promotes PDAC progression and susceptibility to innate immunotherapy

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2023-03-23

OAAI

Zuo, Chong; Baer, John M.; Knolhoff, Brett L.; Belle, Jad, I; Liu, Xiuting; De La Lastra, Angela Alarcon; Fu, Christina; Hogg, Graham D.; Kingston, Natalie L.; Breden, Marcus A.; Dodhiawala, Paarth B.; Zhou, Daniel Cui; Lander, Varintra E.; James, C. Alston; Ding, Li; Lim, Kian-Huat; Fields, Ryan C.; Hawkins, William G.; Weber, Jason D.; Zhao, Guoyan; DeNardo, David G.

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

106

OAAI

Lim, Kian-Huat; Brady, Donita C.; Kashatus, David F.; Ancrile, Brooke B.; Der, Channing J.; Cox, Adrienne D.; Counter, Christopher M.

IRAK4 Signaling Drives Resistance to Checkpoint in Pancreatic Ductal Adenocarcinoma

GASTROENTEROLOGY

IF25.1

2022-06-01

OAAI

Somani, Vikas K.; Zhang, Daoxiang; Dodhiawala, Paarth B.; Lander, Varintra E.; Liu, Xiuting; Kang, Liang-, I; Chen, Hung-Po; Knolhoff, Brett L.; Li, Lin; Grierson, Patrick M.; Ruzinova, Marianna B.; DeNardo, David G.; Lim, Kian-Huat

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (vol 12, 5086, 2021)536患者来源的异种移植模型的综合表征优先考虑靶向治疗的候选者 (第12卷，5086，2021)

NATURE COMMUNICATIONS

IF15.7

2022-01-07

OAAI

Sun, Hua; Cao, Song; Mashl, R. Jay; Mo, Chia-Kuei; Zaccaria, Simone; Wendl, Michael C.; Davies, Sherri R.; Bailey, Matthew H.; Primeau, Tina M.; Hoog, Jeremy; Mudd, Jacqueline L.; Dean, Dennis A., II; Patidar, Rajesh; Chen, Li; Wyczalkowski, Matthew A.; Jayasinghe, Reyka G.; Rodrigues, Fernanda Martins; Terekhanova, Nadezhda V.; Li, Yize; Lim, Kian-Huat; Wang-Gillam, Andrea; Van Tine, Brian A.; Ma, Cynthia X.; Aft, Rebecca; Fuh, Katherine C.; Schwarz, Julie K.; Zevallos, Jose P.; Puram, Sidharth V.; Dipersio, John F.; Davis-Dusenbery, Brandi; Ellis, Matthew J.; Lewis, Michael T.; Davies, Michael A.; Herlyn, Meenhard; Fang, Bingliang; Roth, Jack A.; Welm, Alana L.; Welm, Bryan E.; Meric-Bernstam, Funda; Chen, Feng; Fields, Ryan C.; Li, Shunqiang; Govindan, Ramaswamy; Doroshow, James H.; Moscow, Jeffrey A.; Evrard, Yvonne A.; Chuang, Jeffrey H.; Raphael, Benjamin J.; Ding, Li

The MK2/Hsp27 axis is a major survival mechanism for pancreatic ductal adenocarcinoma under genotoxic stress

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2021-12-01

PREAI

Grierson, Patrick M.; Dodhiawala, Paarth B.; Cheng, Yi; Chen, Timothy Hung-Po; Khawar, Iftikhar Ali; Wei, Qing; Zhang, Daoxiang; Li, Lin; Herndon, John; Monahan, Joseph B.; Ruzinova, Marianna B.; Lim, Kian-Huat

Nonoperative Rectal Cancer Management With Short-Course Radiation Followed by Chemotherapy: A Nonrandomized Control Trial

CLINICAL COLORECTAL CANCER

IF3.2

2021-09-01

PREAI

Kim, Hyun; Pedersen, Katrina; Olsen, Jeffrey R.; Mutch, Matthew G.; Chin, Re-, I; Glasgow, Sean C.; Wise, Paul E.; Silviera, Matthew L.; Tan, Benjamin R.; Wang-Gillam, Andrea; Lim, Kian-Huat; Suresh, Rama; Amin, Manik; Huang, Yi; Henke, Lauren E.; Park, Haeseong; Ciorba, Matthew A.; Badiyan, Shahed; Parikh, Parag J.; Roach, Michael C.; Hunt, Steven R.

Phase 1 study combining alisertib with nab-paclitaxel in patients with advanced solid malignancies

EUROPEAN JOURNAL OF CANCER

IF7.1

2021-09-01

PREAI

Lim, Kian-Huat; Opyrchal, Mateusz; Acharya, Abhi; Boice, Nick; Wu, Ningying; Gao, Feng; Webster, Jace; Lockhart, Albert C.; Waqar, Saiama N.; Govindan, Ramaswamy; Morgensztern, Daniel; Picus, Joel; Tan, Benjamin R.; Baggstrom, Maria Q.; Maher, Christopher A.; Wang-Gillam, Andrea

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment 536患者来源的异种移植模型的综合表征优先考虑靶向治疗的候选者

NATURE COMMUNICATIONS

IF15.7

2021-08-24

OAAI

Sun, Hua; Cao, Song; Mashl, R. Jay; Mo, Chia-Kuei; Zaccaria, Simone; Wendl, Michael C.; Davies, Sherri R.; Bailey, Matthew H.; Primeau, Tina M.; Hoog, Jeremy; Mudd, Jacqueline L.; Dean, Dennis A.; Patidar, Rajesh; Chen, Li; Wyczalkowski, Matthew A.; Jayasinghe, Reyka G.; Rodrigues, Fernanda Martins; Terekhanova, Nadezhda, V; Li, Yize; Lim, Kian-Huat; Wang-Gillam, Andrea; Van Tine, Brian A.; Ma, Cynthia X.; Aft, Rebecca; Fuh, Katherine C.; Schwarz, Julie K.; Zevallos, Jose P.; Puram, Sidharth, V; Dipersio, John F.; Consortium, Nci PDXNet; Davis-Dusenbery, Brandi; Ellis, Matthew J.; Lewis, Michael T.; Davies, Michael A.; Herlyn, Meenhard; Fang, Bingliang; Roth, Jack A.; Welm, Alana L.; Welm, Bryan E.; Meric-Bernstam, Funda; Chen, Feng; Fields, Ryan C.; Li, Shunqiang; Govindan, Ramaswamy; Doroshow, James H.; Moscow, Jeffrey A.; Evrard, Yvonne A.; Chuang, Jeffrey H.; Raphael, Benjamin J.; Ding, Li

研究方向