未登录 PML mutants from arsenic-resistant patients reveal SUMO1-TOPORS and SUMO2/3-RNF4 degradation pathways 来自砷耐药患者的PML突变体揭示了SUMO1-TOPORS和SUMO2/3-RNF4降解通路 Jaffray, Ellis G.; Tatham, Michael H.; Mojsa, Barbara; Plechanovova, Anna; Rojas-Fernandez, Alejandro; Liu, Julio C. Y.; Mailand, Niels; Ibrahim, Adel F. M.; Ball, Graeme; Porter, Iain M.; Hay, Ronald T. 分享 收藏
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation TOPORS和RNF4的协同SUMO靶向泛素连接酶活性对于应激管理和细胞增殖至关重要 Liu, Julio C. Y.; Ackermann, Leena; Hoffmann, Saskia; Gal, Zita; Hendriks, Ivo A.; Jain, Charu; Morlot, Louise; Tatham, Michael H.; Mclelland, Gian-Luca; Hay, Ronald T.; Nielsen, Michael Lund; Brummelkamp, Thijn; Haahr, Peter; Mailand, Niels 分享 收藏
VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Mendez, Blanca Lopez; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels 分享 收藏
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The SUMO-NIP45 pathway processes toxic DNA catenanes to prevent mitotic failure Hertz, Emil P. T.; Alonso-de Vega, Ignacio; Kruse, Thomas; Wang, Yiqing; Hendriks, Ivo A.; Bizard, Anna H.; Eugui-Anta, Ania; Hay, Ronald T.; Nielsen, Michael L.; Nilsson, Jakob; Hickson, Ian D.; Mailand, Niels 分享 收藏
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ATXN3 controls DNA replication and transcription by regulating chromatin structure Hernandez-Carralero, Esperanza; Cabrera, Elisa; Rodriguez-Torres, Gara; Hernandez-Reyes, Yeray; Singh, Abhay N.; Santa-Maria, Cristina; Fernandez-Justel, Jose Miguel; Janssens, Roel C.; Marteijn, Jurgen A.; Evert, Bernd O.; Mailand, Niels; Gomez, Maria; Ramadan, Kristijan; Smits, Veronique A. J.; Freire, Raimundo 分享 收藏
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Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy Grange, Laura J.; Reynolds, John J.; Ullah, Farid; Isidor, Bertrand; Shearer, Robert F.; Latypova, Xenia; Baxley, Ryan M.; Oliver, Antony W.; Ganesh, Anil; Cooke, Sophie L.; Jhujh, Satpal S.; McNee, Gavin S.; Hollingworth, Robert; Higgs, Martin R.; Natsume, Toyoaki; Khan, Tahir; Martos-Moreno, Gabriel A.; Chupp, Sharon; Mathew, Christopher G.; Parry, David; Simpson, Michael A.; Nahavandi, Nahid; Yuksel, Zafer; Drasdo, Mojgan; Kron, Anja; Vogt, Petra; Jonasson, Annemarie; Seth, Saad Ahmed; Gonzaga-Jauregui, Claudia; Brigatti, Karlla W.; Stegmann, Alexander P. A.; Kanemaki, Masato; Josifova, Dragana; Uchiyama, Yuri; Oh, Yukiko; Morimoto, Akira; Osaka, Hitoshi; Ammous, Zineb; Argente, Jesus; Matsumoto, Naomichi; Stumpel, Constance T. R. M.; Taylor, Alexander M. R.; Jackson, Andrew P.; Bielinsky, Anja-Katrin; Mailand, Niels; Le Caignec, Cedric; Davis, Erica E.; Stewart, Grant S. 分享 收藏
Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061 Vit, Gianmatteo; Duro, Joana; Rajendraprasad, Girish; Hertz, Emil P. T.; Holland, Lya Katrine Kauffeldt; Weisser, Melanie Bianca; McEwan, Brennan C.; Lopez-Mendez, Blanca; Sotelo-Parrilla, Paula; Jeyaprakash, A. Arockia; Montoya, Guillermo; Mailand, Niels; Maeda, Kenji; Kettenbach, Arminja; Barisic, Marin; Nilsson, Jakob 分享 收藏
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SCAI promotes error-free repair of DNA interstrand crosslinks via the Fanconi anemia pathway SCAI通过Fanconi贫血途径促进DNA链间交联的无错修复 Schubert, Lisa; Hendriks, Ivo A.; Hertz, Emil P. T.; Wu, Wei; Selles-Baiget, Selene; Hoffmann, Saskia; Viswalingam, Keerthana Stine; Gallina, Irene; Pentakota, Satyakrishna; Benedict, Bente; Johansen, Joachim; Apelt, Katja; Luijsterburg, Martijn S.; Rasmussen, Simon; Lisby, Michael; Liu, Ying; Nielsen, Michael L.; Mailand, Niels; Duxin, Julien P. 分享 收藏
Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway SUMO-RNF4途径DNA复制非依赖性DNA-蛋白质交联修复的机制和功能 Liu, Julio C. Y.; Kuhbacher, Ulrike; Larsen, Nicolai B.; Borgermann, Nikoline; Garvanska, Dimitriya H.; Hendriks, Ivo A.; Ackermann, Leena; Haahr, Peter; Gallina, Irene; Guerillon, Claire; Branigan, Emma; Hay, Ronald T.; Azuma, Yoshiaki; Nielsen, Michael Lund; Duxin, Julien P.; Mailand, Niels 分享 收藏
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Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination 断裂的复制叉上的蛋白质组动力学揭示了抑制DNA双链断裂泛素化的独特的ATM定向修复反应 Nakamura, Kyosuke; Kustatscher, Georg; Alabert, Constance; Hoedl, Martina; Forne, Ignasi; Voelker-Albert, Moritz; Satpathy, Shankha; Beyer, Tracey E.; Mailand, Niels; Choudhary, Chunaram; Imhof, Axel; Rappsilber, Juri; Groth, Anja 分享 收藏
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis Gallina, Irene; Hendriks, Ivo A.; Hoffmann, Saskia; Larsen, Nicolai B.; Johansen, Joachim; Colding-Christensen, Camilla S.; Schubert, Lisa; Selles-Baiget, Selene; Fabian, Zita; Kuhbacher, Ulrike; Gao, Alan O.; Raeschle, Markus; Rasmussen, Simon; Nielsen, Michael L.; Mailand, Niels; Duxin, Julien P. 分享 收藏
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease Hoffmann, Saskia; Pentakota, Satyakrishna; Mund, Andreas; Haahr, Peter; Coscia, Fabian; Gallo, Marta; Mann, Matthias; Taylor, Nicholas M., I; Mailand, Niels 分享 收藏
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The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8 Singh, Abhay Narayan; Oehler, Judith; Torrecilla, Ignacio; Kilgas, Susan; Li, Shudong; Vaz, Bruno; Guerillon, Claire; Fielden, John; Esperanza Hernandez-Carralero; Cabrera, Elisa; Tullis, Iain D. C.; Meerang, Mayura; Barber, Paul R.; Freire, Raimundo; Parsons, Jason; Vojnovic, Borivoj; Kiltie, Anne E.; Mailand, Niels; Ramadan, Kristijan 分享 收藏
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