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Yasuyuki Sakai

University of Pennsylvania

38H指数
323论文数
6.7K被引数
收录论文 117
发表时间
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Proteomic analysis reveals a metabolic switch and cellular remodelling in pancreatic-like cell spheroids cocultured with hepatocyte-like cells using an interconnected liver-pancreas-on-chip system蛋白质组学分析揭示使用互连的肝-胰腺芯片系统共培养的类胰腺细胞球与类肝细胞共培养中的代谢转换和细胞重塑
errMolecular Omics
IF2.4
err2026-08-26
err0
PREAI
errAmal Essaouiba; Jérôme Vicogne; Alexandre Stella; Mathieu Danoy; Anne Gonzalez de Peredo; Cécile Legallais; Yasuyuki Sakai; Rachid Jellali; Eric Leclerc
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A novel sorting method uncovers metabolic heterogeneity between mononucleated and binucleated tetraploid hepatocytes一种新型分选方法揭示了单核细胞和多核四倍体肝细胞之间的代谢异质性
errJournal of Biological Chemistry
IF3.9
err2026-08-01
err0
PREAI
errWatanabe, Yusuke, V; Sussman, Jonathan H.; Anami, Tomoya; Shimodaira, Gaku; Hattori, Moena; Yamane, Saaya; Nishikawa, Masaki; Sakai, Yasuyuki; Katsuda, Takeshi
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Organoid bioprinting for vascularized tumor assembloids类器官生物打印用于血管化肿瘤组装体
errTrends in Biotechnology
IF14.9
err2026-05-07
err0
PREAI
errZhenzhen Zhou; Yuan Pang; Zhendong Liao; Chang Zhou; Meiling Fu; Changru Liu; Yuting Guo; Kamto Yang; Jianyu He; Botao Gao; Marie Shinohara; Yasuyuki Sakai; Wei Sun
err分享
err收藏
A proof-of-concept study on high pressure freezing for cryopreservation一项关于高压冷冻在低温保存中应用的概念验证研究
errPNAS Nexus
IF3.8
err2026-03-20
err0
errOAAI
errFang Song; Mayuko Sato; Yuya Toyama; Taiyo Ishikawa; Fumiya Tokito; Takeshi Katsuda; Kiminori Toyooka; Yasuyuki Sakai; Masaki Nishikawa
err分享
err收藏
A Computational Model of Inflammation Reveals Crosstalk among Energy Metabolism, Oxidative Stress, Insulin, and Cytokines in Hepatocytes during Early MASLD Progression
errToxicological Sciences
IF4.1
err2025-12-17
err0
PREAI
errYuki Miura; Yasuyuki Sakai; Masaki Nishikawa; Eric Leclerc
err分享
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Palmitic acid induced the onset of lipotoxicity in a HepaSH-on-chip model with raised of H2O2 and IL-6, and altered p38/MAPK & JAK/STAT pathways棕榈酸在HepaSH-on-chip模型中诱导了脂毒性，伴随H2O2和IL-6水平升高，并改变了p38/MAPK和JAK/STAT通路。
errToxicology
IF4.6
err2025-11-22
err0
PREAI
errHanyuan Wang; Stéphane Poulain; Wenxin Cao; Hiroshi Arakawa; Soo Hyeon Kim; Yukio Kato; Masaki Nishikawa; Yasuyuki Sakai; Eric Leclerc
err分享
err收藏
PS19.2: Modeling early vascular-mesenchymal interactions in human endochondral ossification using human embryonic-stem-cell-derived organoid on a microfluidic chip.PS19.2: 使用人类胚胎干细胞来源的类器官在微流控芯片上模拟人类软骨内成骨过程中的早期血管-间充质相互作用。
errTransplantation
IF5
err2025-10-20
err0
PREAI
errKesharwani, Abhiraj; Tani, Shoichiro; Nishikawa, Masaki; Sakai, Yasuyuki; Okada, Hiroyuki; Ohba, Shinsuke; Chung, Ung-il; Hojo, Hironori
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Computational modeling of the hepatocytes reveals new insights into alterations in drug metabolism, oxidative stress response, and glutathione detoxification in acetaminophen-induced hepatotoxicity associated with MASLD肝细胞计算建模揭示了关于与MASLD相关的对乙酰氨基酚诱导肝毒性中药物代谢、氧化应激反应和谷胱甘肽解毒变化的新的见解。
errComputational Toxicology
IF2.9
err2025-09-27
err0
PREAI
errYuki Miura; Yasuyuki Sakai; Masaki Nishikawa; Eric Leclerc
err分享
err收藏
3D hepatic spheroids and liver-organ on chip models displayed maintenance of hepatic functions and maturation profile in a long-term culture of the humanized HepaSH cells, a human cell population harvested from chimeric mice3D肝细胞球体和肝器官芯片模型显示，在长期培养的人类化HepaSH细胞（一种从嵌合小鼠中获取的人类细胞群）中，保持了肝功能维持和成熟表型。
errBiotechnology Progress
IF2.5
err2025-05-31
err0
PREAI
errHanyuan Wang; Carla Meschini; Stéphane Poulain; Soo Hyeon Kim; Hiroshi Arakawa; Yukio Kato; Cecile Legallais; Ulysse Pereira; Yasuyuki Sakai; Eric Leclerc
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Transcriptomic characterization of the synergy between human induced pluripotent stem cells-derived liver- and pancreas-on-chip coculture人诱导多能干细胞衍生的肝脏-和胰腺-芯片共培养的转录组学表征及其协同作用
errMolecular and Cellular Endocrinology
IF3.6
err2025-05-21
err0
PREAI
errAmal Essaouiba; Rachid Jellali; Stéphane Poulain; Soo Hyeon Kim; Mathieu Danoy; Cécile Legallais; Yasuyuki Sakai; Eric Leclerc
err分享
err收藏
Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure利用化学诱导的人源多能干细胞来源的功能性肝细胞类器官进行生物打印以治疗肝衰竭
errGUT
IF25.8
err2025-03-03
err1
PREAI
errLi, Guangya; He, Jianyu; Shi, Jihang; Li, Xinyi; Liu, Lulu; Ge, Xinlan; Chen, Wenhan; Jia, Jun; Wang, Jinlin; Yin, Ming; Sakai, Yasuyuki; Sun, Wei; Deng, Hongkui; Pang, Yuan
err分享
err收藏
Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid
errREGENERATIVE THERAPY
IF3.5
err2025-03-01
err0
PREAI
errKesharwani, Abhiraj; Tani, Shoichiro; Nishikawa, Masaki; Sakai, Yasuyuki; Okada, Hiroyuki; Ohba, Shinsuke; Chung, Ung-il; Hojo, Hironori
err分享
err收藏
A computational model of the crosstalk between hepatocyte fatty acid metabolism and oxidative stress highlights the key enzymes, metabolites, and detoxification pathways in the context of MASLD
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2025-02-01
err0
PREAI
errMiura, Yuki; Voican, Cosmin; Sakai, Yasuyuki; Nishikawa, Masaki; Leclerc, Eric
err分享
err收藏
Establishment of human induced pluripotent stem cell-derived hepatobiliary organoid with bile duct for pharmaceutical research use用于药物研究的人诱导多能干细胞衍生的肝胆器官与胆管的建立
errBIOMATERIALS
IF12.9
err2024-10-01
err2
PREAI
errWang, Luyao; Koui, Yuta; Kido, Taketomo; Yabe, Shigeharu; Tai, Kenpei; Nakajima, Yoshiko; Kusuhara, Hiroyuki; Sakai, Yasuyuki; Miyajima, Atsushi; Okochi, Hitoshi; Tanaka, Minoru
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Size-Dependent Internalization of Microplastics and Nanoplastics Using In Vitro Model of the Human Intestine-Contribution of Each Cell in the Tri-Culture Models使用人肠道体外模型的微塑料和纳米塑料的尺寸依赖性内化-三培养模型中每个细胞的贡献
errNANOMATERIALS
IF4.3
err2024-09-02
err1
errOAAI
errChoi, Hyunjin; Kaneko, Shohei; Suzuki, Yusei; Inamura, Kosuke; Nishikawa, Masaki; Sakai, Yasuyuki
err分享
err收藏
Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro
errBIOFABRICATION
IF8
err2024-03-25
err0
PREAI
errScheidecker, Benedikt; Poulain, Stephane; Sugimoto, Masahiro; Kido, Taketomo; Kawanishi, Takumi; Miyajima, Atsushi; Kim, Soo Hyeon; Arakawa, Hiroshi; Kato, Yukio; Nishikawa, Masaki; Danoy, Mathieu; Sakai, Yasuyuki; Leclerc, Eric
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err收藏
Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects
errREGENERATIVE THERAPY
IF3.5
err2024-03-01
err2
errOAAI
errNepal, Shant; Si, Jinyan; Ishikawa, Shohei; Nishikawa, Masaki; Sakai, Yasuyuki; Akimoto, Aya M.; Okada, Hiroyuki; Ohba, Shinsuke; Chung, Ung-il; Sakai, Takamasa; Hojo, Hironori
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Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism肠-肝微生理系统揭示了调节药物代谢的潜在串扰机制
errPNAS NEXUS
IF3.8
err2024-02-09
err4
errOAAI
errKurniawan, Dhimas Agung; Leo, Sylvia; Inamatsu, Mutsumi; Funaoka, Sohei; Aihara, Taichi; Aiko, Mizuno; Rei, Inoue; Sakura, Takeshi; Arakawa, Hiroshi; Kato, Yukio; Matsugi, Tomoaki; Esashika, Katsuhiro; Shiraki, Nobuaki; Kume, Shoen; Shinha, Kenta; Kimura, Hiroshi; Nishikawa, Masaki; Sakai, Yasuyuki
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Mechanobiological stimulation in organ-on-a-chip systems reduces hepatic drug metabolic capacity in favor of regenerative specialization
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2024-01-07
err1
PREAI
errScheidecker, Benedikt; Poulain, Stephane; Sugimoto, Masahiro; Arakawa, Hiroshi; Kim, Soo H.; Kawanishi, Takumi; Kato, Yukio; Danoy, Mathieu; Nishikawa, Masaki; Sakai, Yasuyuki
err分享
err收藏
A highly efficient cell culture method using oxygen-permeable PDMS-based honeycomb microwells produces functional liver organoids from human induced pluripotent stem cell-derived carboxypeptidase M liver progenitor cells
errBIOTECHNOLOGY AND BIOENGINEERING
IF3.6
err2024-01-07
err3
errOAAI
errUtami, Tia; Danoy, Mathieu; Khadim, Rubina Rahaman; Tokito, Fumiya; Arakawa, Hiroshi; Kato, Yukio; Kido, Taketomo; Miyajima, Atsushi; Nishikawa, Masaki; Sakai, Yasuyuki
err分享
err收藏

研究方向

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合作学者
合作期刊
A
Ali Khademhosseini
H 指数: 177 · 论文数: 1.1K
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H 指数: 128 · 论文数: 522
R
Roger D. Kamm
H 指数: 117 · 论文数: 769
T
Takahiro Ochiya
H 指数: 102 · 论文数: 686
N
Nam‐Trung Nguyen
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