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J

Jessica A. Downs

The Institute of Cancer Research

34H指数
120论文数
4.8K被引数
收录论文 48
发表时间
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Keeping forks in the loop: how chromatin architecture shields stalled replication forks将叉子保持在循环中：染色质结构如何保护停滞的复制叉
errSignal Transduction and Targeted Therapy
IF52.7
err2026-09-25
err0
errOAAI
errNagham Ghaddar; Jessica A. Downs
err分享
err收藏
The SMARCA4 subunit of the SWI/SNF complex prevents genome instability at G quadruplexesSWI/SNF复合物的SMARCA4亚基可防止G四链体的基因组不稳定性
errGenome Biology
IF9.4
err2026-04-20
err0
errOAAI
errAlison Harrod; Hugang Feng; Nagham Ghaddar; Federica Schiavoni; Karen A. Lane; Lillian Wu; Pedro Zuazua-Villar; Zuzanna Kozik; Felix M. Dobbs; Patrick van Eijk; Gene Ching Chiek Koh; Navita Somaiah; Jyoti Choudhary; Serena Nik-Zainal; Simon H. Reed; Jessica A. Downs
err分享
err收藏
The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJCIP2A-TOPBP1轴通过MiDAS和MMEJ促进有丝分裂DNA修复
errNature Communications
IF15.7
err2025-11-27
err0
errOAAI
errPeter R. Martin; Jadwiga Nieminuszczy; Zuza Kozik; Nihal Jakub; Szymon Kowalski; Maxime Lecot; Julia Vorhauser; Karen A. Lane; Alexandra Kanellou; Jörg Mansfeld; Laurence H. Pearl; Antony W. Oliver; Jessica A. Downs; Jyoti S. Choudhary; Matthew Day; Wojciech Niedzwiedz
err分享
err收藏
ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatinARID1A通过G4配体pyridostatin诱导的DNA断裂稳定非同源末端连接因子
errCell Reports
IF6.9
err2025-09-11
err0
errOAAI
errSusana Simões-Sousa; Noa Amin; Karen A. Lane; Alison Harrod; Malin Pedersen; Mercedes Pardo; Christine Rasetti-Escargueil; Zuzanna Kozik; Katheryn A.G. Begg; Alison Ribeiro; Susana Banerjee; Manuel Stucki; Kevin J. Harrington; Jyoti S. Choudhary; Jessica A. Downs
err分享
err收藏
Chromatin remodeling and spatial concerns in DNA double-strand break repairDNA双链断裂修复中的染色质重塑和空间问题
errCURRENT OPINION IN CELL BIOLOGY
IF4.3
err2024-10-01
err1
errOAAI
errDowns, Jessica A.; Gasser, Susan M.
err分享
err收藏
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
errDNA REPAIR
IF2.7
err2024-01-01
err4
PREAI
errBegg, Katheryn A. G.; Braun, Hanna; Ghaddar, Nagham; Wu, Lillian; Downs, Jessica A.
err分享
err收藏
Interdependent interactions between TFIIB, TATA binding protein, and DNA
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err15
errOAAI
errBuratowski, RM; Downs, J; Buratowski, S
err分享
err收藏
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase钉书钉肽发现的重组方法可产生RAD51重组酶的抑制剂
errCHEMICAL SCIENCE
IF7.4
err2023-01-01
err2
errOAAI
errPantelejevs, Teodors; Zuazua-Villar, Pedro; Koczy, Oliwia; Counsell, Andrew J.; Walsh, Stephen J.; Robertson, Naomi S.; Spring, David R.; Downs, Jessica A.; Hyvonen, Marko
err分享
err收藏
Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
errNATURE COMMUNICATIONS
IF15.7
err2022-04-01
err11
errOAAI
errSchiavoni, Federica; Zuazua-Villar, Pedro; Roumeliotis, Theodoros, I; Benstead-Hume, Graeme; Pardo, Mercedes; Pearl, Frances M. G.; Choudhary, Jyoti S.; Downs, Jessica A.
err分享
err收藏
Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats基于BRC重复序列的模块性，通过基序改组改进RAD51结合剂
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-11-11
err8
errOAAI
errLindenburg, Laurens H.; Pantelejevs, Teodors; Gielen, Fabrice; Zuazua-Villar, Pedro; Butz, Maren; Rees, Eric; Kaminski, Clemens F.; Downs, Jessica A.; Hyvonen, Marko; Hollfelder, Florian
err分享
err收藏
PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in CancerPBRM1缺乏使癌症中的DNA修复抑制剂具有合成致死率
errCANCER RESEARCH
IF16.6
err2021-04-23
err68
errOAAI
errChabanon, Roman M.; Morel, Daphne; Eychenne, Thomas; Colmet-Daage, Leo; Bajrami, Ilirjana; Dorvault, Nicolas; Garrido, Marlene; Meisenberg, Cornelia; Lamb, Andrew; Ngo, Carine; Hopkins, Suzanna R.; Roumeliotis, Theodoros, I; Jouny, Samuel; Henon, Clemence; Kawai-Kawachi, Asuka; Astier, Clemence; Konde, Asha; Del Nery, Elaine; Massard, Christophe; Pettitt, Stephen J.; Margueron, Raphael; Choudhary, Jyoti S.; Almouzni, Genevieve; Soria, Jean-Charles; Deutsch, Eric; Downs, Jessica A.; Lord, Christopher J.; Postel-Vinay, Sophie
err分享
err收藏
Histone isoforms and the oncohistone code
errCURRENT OPINION IN GENETICS & DEVELOPMENT
IF3.6
err2021-04-01
err14
PREAI
errFlaus, Andrew; Downs, Jessica A.; Owen-Hughes, Tom
err分享
err收藏
TP53 modulates radiotherapy fraction size sensitivity in normal and malignant cells
errSCIENTIFIC REPORTS
IF3.9
err2021-03-29
err16
errOAAI
errAnbalagan, Selvakumar; Stroem, Cecilia; Downs, Jessica A.; Jeggo, Penny A.; McBay, David; Wilkins, Anna; Rothkamm, Kai; Harrington, Kevin J.; Yarnold, John R.; Somaiah, Navita
err分享
err收藏
Differential and longitudinal immune gene patterns associated with reprogrammed microenvironment and viral mimicry in response to neoadjuvant radiotherapy in rectal cancer直肠癌新辅助放疗后与重编程微环境和病毒模拟相关的差异和纵向免疫基因模式
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2021-03-07
err17
errOAAI
errWilkins, Anna; Fontana, Elisa; Nyamundanda, Gift; Ragulan, Chanthirika; Patil, Yatish; Mansfield, David; Kingston, Jennifer; Errington-Mais, Fiona; Bottomley, Daniel; von Loga, Katharina; Bye, Hannah; Carter, Paul; Tinkler-Hundal, Emma; Noshirwani, Amir; Downs, Jessica; Dillon, Magnus; Demaria, Sandra; Sebag-Montefiore, David; Harrington, Kevin; West, Nick; Melcher, Alan; Sadanandam, Anguraj
err分享
err收藏
CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
errNATURE COMMUNICATIONS
IF15.7
err2020-11-13
err31
errOAAI
errRother, Magdalena B.; Pellegrino, Stefania; Smith, Rebecca; Gatti, Marco; Meisenberg, Cornelia; Wiegant, Wouter W.; Luijsterburg, Martijn S.; Imhof, Ralph; Downs, Jessica A.; Vertegaal, Alfred C. O.; Huet, Sebastien; Altmeyer, Matthias; van Attikum, Haico
err分享
err收藏
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaksSWI/SNF染色质重塑复合物在DNA双链断裂反应中的作用
errDNA REPAIR
IF2.7
err2020-09-01
err39
PREAI
errHarrod, Alison; Lane, Karen A.; Downs, Jessica A.
err分享
err收藏
Targeting chromatin remodeling-associated genetic vulnerabilities in cancer: PBRM1 defects are synthetic lethal with PARP and ATR inhibitors
errCANCER RESEARCH
IF16.6
err2020-08-15
err2
PREAI
errChabanon, Roman Merial; Morel, Daphne; Colmet-Daage, Leo; Eychenne, Thomas; Dorvault, Nicolas; Bajrami, Ilirjana; Garrido, Marlene; Hopkins, Suzanna; Meisenberg, Cornelia; Lamb, Andrew; Roumeliotis, Theo; Jouny, Samuel; Astier, Clemence; Konde, Asha; Almouzni, Genevieve; Choudhary, Jyoti; Soria, Jean-Charles; Downs, Jessica; Lord, Christopher J.; Postel-Vinay, Sophie
err分享
err收藏
Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
errMOLECULAR CELL
IF16.6
err2019-01-01
err86
errOAAI
errMeisenberg, Cornelia; Pinder, Sarah I.; Hopkins, Suzanna R.; Wooller, Sarah K.; Benstead-Hume, Graeme; Pearl, Frances M. G.; Jeggo, Penny A.; Downs, Jessica A.
err分享
err收藏
Targeting the epigenetic regulator KAT2a in cancer
errCANCER RESEARCH
IF16.6
err2018-07-01
err0
PREAI
errGunnell, Andrea; Downs, Jessica; Pennicott, Lewis; Osborn, Kay; Le Grand, Darren; Duffell, Katie; Patel, Hitesh; Hudson, Jessica; Booth, Jessica R.; Ward, Simon
err分享
err收藏
Cell cycle checkpoint modulates radiotherapy fraction size sensitivity in normal and malignant cells
errRADIOTHERAPY AND ONCOLOGY
IF5.3
err2018-04-01
err1
errOAAI
errSomaiah, N.; Anbalagan, S.; Strom, C.; Downs, J.; Jeggo, P.; Wilkins, A.; Boyle, S.; Rothkamm, K.; Yarnold, J.
err分享
err收藏

研究方向

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