Histone isoforms and the oncohistone code

Andrew Flaus

doi:10.1016/j.gde.2020.11.003

2021-04-01

PRE

Andrew Flaus

Jessica A. Downs *

Tom Owen‐Hughes *

DOI：10.1016/j.gde.2020.11.003

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摘要

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Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene families. There is heterogeneity among these genes at the level of the underlying sequence, the amino acid composition of the encoded histone isoform, and the expression levels. One question that arises, therefore, is whether all histone-encoding genes function equally as oncohistones. In this review, we consider this question and explore what this means in terms of the mechanisms by which oncohistones can exert their effects in chromatin.

Keyword:

VARIANTS TH2A

MUTATIONS

STABILITY

GAIN

H2AX

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Current Opinion in Genetics and Development

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3.6

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ollscoil na gaillimhe-university of galway

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university of london

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institute of cancer research - uk

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