David J. Irwin

University of Pennsylvania

H指数:75

被引数:2.5万

个人简介

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教育背景

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工作经历

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荣誉奖项

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An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration

乙酰化Tau-174 CSF生物标志物区分额颞叶变性患者的TDP-43和tau病理

Nature Medicine

IF50

2026-04-150

OAAI

Madison I. J. Honey; Yanaika S. Hok-A-Hin; Elisabeth H. Thijssen; Katheryn A. Q. Cousins; Babette van der Weijden; Lisanne in ‘t Veld; Erik Stoops; Sterre C. M. de Boer; Flora H. Duits; Julie F. H. de Houwer; Tjado H. J. Morrema; Daniel Alcolea; Ignacio Illán-Gala; Juan Fortea; Alberto Lleó; Adam L. Boxer; David J. Irwin; Edward B. Lee; Leslie Shaw; Corey T. McMillan; David A. Wolk; Jeroen J. M. Hoozemans; Wiesje M. van der Flier; Emma van der Ende; Harro Seelaar; Inge M. W. Verberk; Li Gan; Yolande Pijnenburg; Charlotte E. Teunissen

Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease

血浆P-tau217与帕金森病中阿尔茨海默病共病理性及认知下降的关系

Annals of Neurology

IF7.7

2026-03-180

OAAI

Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling

Annals of Neurology

IF7.7

2026-01-290

OAAI

Shubir Dutt PhD; Dana Leichter BS; Yann Cobigo PhD; Amy Wolf BS; John Kornak PhD; Annie Clark MS; Lucy L. Russell PhD; Arabella Bouzigues MSc; David M. Cash PhD; Martina Bocchetta PhD; Molly Olzinski BS; Brian Appleby MD; Ece Bayram MD, PhD; Barbara Borroni MD; Andrea Bozoki MD; Chris R. Butler PhD; David Clark MD; Rhian S. Convery MSc; R. Ryan Darby MD; Alexandre de Mendonça PhD; Bradford Dickerson MD; Kimiko Domoto-Reilly MD; Simon Ducharme MD; Eve Ferry-Bolder BA; Elizabeth Finger MD; Phoebe H. Foster BSc; Douglas R. Galasko MD; Daniela Galimberti PhD; Alexander Gerhard MD; Nupur Ghoshal MD; Caroline Graff PhD; Neill Graff-Radford MD; Ian M. Grant MD; Chadwick M. Hales MD, PhD; Lawrence S. Honig MD, PhD; Ging-Yuek Hsiung MD; Edward D. Huey MD; David Irwin MD; Lize C. Jiskoot PhD; Walter Kremers PhD; Justin Y. Kwan MD; Robert Laforce MD; Isabelle Le Ber PhD; Gabriel C. Léger MD; Johannes Levin MD; Irene Litvan MD, MSc; Ian R. Mackenzie MD; Mario Masellis PhD; Mario F. Mendez MD, PhD; Fermin Moreno PhD; Chiadi Onyike MD, MHS; Markus Otto MD; Belen Pascual PhD; Peter Pressman MD; Rosa Rademakers PhD; Eliana Marisa Ramos PhD; Aaron Ritter MD; Erik D. Roberson MD, PhD; James B. Rowe PhD; Raquel Sanchez-Valle MD; Isabel Santana PhD; Harro Seelaar PhD; Allison Snyder MD; Sandro Sorbi PhD; Matthis Synofzik MD; Maria Carmela Tartaglia MD; Pietro Tiraboschi MD; John C. van Swieten MD, PhD; Marijne Vandebergh PhD; Rik Vandenberghe MD; Hilary W. Heuer PhD; Bruce L. Miller MD; William W. Seeley MD; Maria Luisa Gorno-Tempini MD; Joel H. Kramer PsyD; Leah Forsberg PhD; Kejal Kantarci MD; Bradley F. Boeve MD; Adam L. Boxer MD, PhD; Jonathan D. Rohrer PhD; Howard J. Rosen MD; Adam M. Staffaroni PhD; FTD Prevention Initiative (FPI) investigators

Interim Safety and Biomarker Data From upliFT‐D Trial of PBFT02 in FTD with GRN Mutations

upliFT‐D试验中PBFT02治疗GRN基因突变型额颞叶痴呆的 interim 安全性和生物标志物数据

Alzheimers & Dementia

IF11.1

2025-12-250

OAAI

Where do PDD and DLB SYNdromes fit in neuronal alpha-SYNuclein biological frameworks?

PDD和DLB综合征在神经元α-突触核蛋白生物学框架中处于什么位置？

Journal of Neural Transmission

IF4

2025-12-040

OAAI

The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies

TDP-43 PET配体对TDP-43蛋白病的生物学诊断的潜力

Nature Communications

IF15.7

2025-10-240

OAAI

Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease

连接性作为非典型阿尔茨海默病中tau进展的通用预测因子。

BRAIN

IF11.7

2025-10-012

PRE

de Bruin, Hannah; Groot, Colin; Barthel, Henryk; Bischof, Gerard N.; Blazhenets, Ganna; Boellaard, Ronald; Boon, Baayla D. C.; Brendel, Matthias; Cash, David M.; Coath, William; Day, Gregory S.; Dickerson, Bradford C.; Doering, Elena; Drzezga, Alexander; van Dyck, Christopher H.; van Eimeren, Thilo; van der Flier, Wiesje M.; Fredericks, Carolyn A.; Fryer, Tim D.; van de Giessen, Elsmarieke; Gordon, Brian A.; Graff-Radford, Jonathan; Grinberg, Lea T.; Hansson, Oskar; Hobbs, Diana A.; Hoenig, Merle C.; Hoglinger, Gunter; Irwin, David J.; Jones, P. Simon; Josephs, Keith A.; Katsumi, Yuta; La Joie, Renaud; Lee, Edward B.; Levin, Johannes; Malpetti, Maura; Mcginnis, Scott M.; Mecca, Adam P.; Mohanty, Rosaleena; Nasrallah, Ilya M.; O'Brien, John T.; O'Dell, Ryan S.; Palleis, Carla; Perneczky, Robert; Phillips, Jeffrey S.; Putcha, Deepti; Rabinovici, Gil D.; Rahmouni, Nesrine; Rosa-Neto, Pedro; Rowe, James B.; Rullmann, Michael; Sabri, Osama; Saur, Dorothee; Schildan, Andreas; Schott, Jonathan M.; Schroeter, Matthias L.; Seeley, William W.; Servaes, Stijn; Sintini, Irene; Smith, Ruben; Spina, Salvatore; Stevenson, Jenna; Stomrud, Erik; Strandberg, Olof; Therriault, Joseph; Tideman, Pontus; Touroutoglou, Alexandra; Trainer, Anne E.; Visser, Denise; Wekselman, Fattin; Weston, Philip S. J.; Whitwell, Jennifer L.; Wolk, David A.; Yong, Keir; Pijnenburg, Yolande A. L.; Franzmeier, Nicolai; Ossenkoppele, Rik

Performance of 123I-ioflupane SPECT striatal binding in dementia with Lewy bodies

123I-ioflupane SPECT纹状体结合在路易体痴呆中的性能

Alzheimer's & Dementia

IF11.1

2025-09-160

OAAI

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia

大规模CSF蛋白质组学分析鉴定了用于额颞叶痴呆准确诊断的生物标志物

Molecular Neurodegeneration

IF17.5

2025-08-280

OAAI

Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease

比较不同种族中血浆p-tau217/Aβ42、p-tau217和Aβ42/Aβ40生物标志物对阿尔茨海默病的检测能力

Alzheimer's & Dementia

IF11.1

2025-08-130

OAAI

Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia

执行功能障碍与行为变异型额颞叶痴呆中的显著性网络解离有关

neuroimage clinical

IF0

2025-07-240

OAAI

Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G

与VCP D395G相关的空泡状tau蛋白病的临床病理学特征

Alzheimer's & Dementia

IF11.1

2025-07-180

OAAI

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration

通过衰老和神经退行性变的变革性神经病理学加速脑健康生物医学发现

Neuron

IF15

2025-07-180

OAAI

Melissa E. Murray; Colin Smith; Vilas Menon; C. Dirk Keene; Ed Lein; Michael Hawrylycz; Adriano Aguzzi; Brett Benedetti; Katja Brose; Kelsey Caetano-Anolles; Maria Inmaculada Cobos Sillero; John F. Crary; Philip L. De Jager; Arline Faustin; Margaret E. Flanagan; Ozgun Gokce; Seth G.N. Grant; Lea T. Grinberg; David A. Gutman; Elizabeth M.C. Hillman; Zhi Huang; David J. Irwin; David T. Jones; Alifiya Kapasi; Celeste M. Karch; Walter T. Kukull; Tammaryn Lashley; Edward B. Lee; Thomas Lehner; Laura Parkkinen; Maria Pedersen; Dominique Pritchett; Matthew H. Rutledge; Julie A. Schneider; William W. Seeley; Claire E. Shepherd; Tara L. Spires-Jones; Judith A. Steen; Margaret Sutherland; Sanja Vickovic; Bin Zhang; David J. Stewart; Michael J. Keiser; Jacob W. Vogel; Brittany N. Dugger; Hemali Phatnani

Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia

行为变异型额颞叶痴呆临床表型的性别差异

ALZHEIMERS & DEMENTIA

IF11.1

2025-04-251

OAAI

Liu, XL; de Boer, SCM; Cortez, K; Poos, JM; Illán-Gala, I; Heuer, H; Forsberg, LK; Casaletto, K; Memel, M; Appleby, BS; Barmada, S; Bozoki, A; Clark, D; Cobigo, Y; Darby, R; Dickerson, BC; Domoto-Reilly, K; Galasko, DR; Geschwind, DH; Ghoshal, N; Graff-Radford, NR; Grant, IM; Hsiung, GYR; Honig, LS; Huey, ED; Irwin, D; Kantarci, K; Léger, GC; Litvan, I; Mackenzie, IR; Masdeu, JC; Mendez, MF; Onyike, CU; Pascual, B; Pressman, P; Bayram, E; Ramos, EM; Roberson, ED; Rogalski, E; Bouzigues, A; Russell, LL; Foster, PH; Ferry-Bolder, E; Masellis, M; van Swieten, J; Jiskoot, L; Seelaar, H; Sanchez-Valle, R; Laforce, R; Graff, C; Galimberti, D; Vandenberghe, R; de Mendonça, A; Tiraboschi, P; Santana, I; Gerhard, A; Levin, J; Sorbi, S; Otto, M; Pasquier, F; Ducharme, S; Butler, CR; Le Ber, I; Finger, E; Rowe, JB; Synofzik, M; Moreno, F; Borroni, B; Boeve, BF; Boxer, AL; Rosen, HJ; Pijnenburg, YAL; Rohrer, JD; Tartaglia, MC

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing

通过全基因组测序破译ftld-tdp病理亚型的不同遗传危险因素

NATURE COMMUNICATIONS

IF15.7

2025-04-250

Pottier, Cyril; Kuecuekali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D.; van Blitterswijk, Marka; Vicente, Cristina T.; De Coster, Wouter; Wynants, Sarah; van de Walle, Pieter; Ross, Owen A.; Murray, Melissa E.; Faura, Julia; Haggarty, Stephen J.; van Rooij, Jeroen GJ.; Mol, Merel O.; Hsiung, Ging-Yuek R.; Graff, Caroline; Oeijerstedt, Linn; Neumann, Manuela; Asmann, Yan; Mcdonnell, Shannon K.; Baheti, Saurabh; Josephs, Keith A.; Whitwell, Jennifer L.; Bieniek, Kevin F.; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G.; Yokoyama, Jennifer S.; Oddi, Alexis P.; Flanagan, Margaret; Mao, Qinwen; Hodges, John R.; Kwok, John B.; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C.; Evers, Bret M.; Dugger, Brittany N.; Munoz, David G.; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, Eunran; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R.; Edbauer, Dieter; Woodruff, Bryan K.; Caselli, Richard J.; Donker Kaat, Laura L.; Huey, Edward D.; Reiman, Eric M.; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L.; Ertekin-Taner, Nilufer; Knopman, David S.; Petersen, Ronald C.; Petrucelli, Leonard; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ramos, Eliana Marisa; Grinberg, Lea T.; Tempini, Maria Luisa Gorno; Rosen, Howard J.; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q.; Keene, C. Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H.; Rissman, Robert A.; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M.; Beach, Thomas G.; Serrano, Geidy E.; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L.; Honig, Lawrence S.; Vonsattel, Jean P.; Lopez, Oscar L.; Kofler, Julia; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D.; Irwin, David J.; Lee, Edward B.; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M.; Tartaglia, Maria C.; Finger, Elizabeth C.; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L.; Miller, Bruce L.; Seelaar, Harro; Graff-Radford, Neill R.; Boeve, Bradley F.; Mackenzie, Ian RA.; van Swieten, John C.; Seeley, William W.; Sleegers, Kristel; Dickson, Dennis W.; Biernacka, Joanna M.; Rademakers, Rosa

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders

全面的血浆胶质纤维酸性蛋白和神经丝蛋白轻链在额颞叶痴呆谱系障碍中的横断面和纵向比较

MOLECULAR NEURODEGENERATION

IF17.5

2025-03-120

Sheth, Udit; Oijerstedt, Linn; Heckman, Michael G.; White, Launia J.; Heuer, Hilary W.; Lario Lago, Argentina; Forsberg, Leah K.; Faber, Kelley M.; Foroud, Tatiana M.; Rademakers, Rosa; Ramos, Eliana Marisa; Appleby, Brian S.; Bozoki, Andrea C.; Darby, R. Ryan; Dickerson, Bradford C.; Domoto-Reilly, Kimiko; Galasko, Douglas R.; Ghoshal, Nupur; Graff-Radford, Neill R.; Grant, Ian M.; Hales, Chadwick M.; Hsiung, Ging-Yuek Robin; Huey, Edward D.; Irwin, David; Kwan, Justin Y.; Litvan, Irene; Mackenzie, Ian R.; Masdeu, Joseph C.; Mendez, Mario F.; Onyike, Chiadi U.; Pascual, Belen; Pressman, Peter S.; Roberson, Erik D.; Snyder, Allison; Tartaglia, M. Carmela; Seeley, William W.; Dickson, Dennis W.; Rosen, Howard J.; Boeve, Bradley F.; Boxer, Adam L.; Petrucelli, Leonard; Gendron, Tania F.

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration

与遗传性行为变异型额颞叶萎缩相关的差异性和共享性转录组特征

MOLECULAR NEURODEGENERATION

IF17.5

2025-02-070