Yuan Yan Sin

university of glasgow

H指数:16

被引数:849

个人简介

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教育背景

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工作经历

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荣誉奖项

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The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

使用PROTAC选择性降解PDE4B短型，可抑制HCT116细胞中的多种癌症标志物

British Journal of Pharmacology

IF7.7

2026-07-290

OAAI

KTX207-mediated PDE4D degradation disrupts tumour cell migration, invasion, and angiogenic potential

KTX207介导的PDE4D降解破坏肿瘤细胞迁移、侵袭和血管生成潜能

Cell Communication and Signaling

IF8.9

2026-05-210

Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders

PDE4B和PDE4D选择性双功能降解剂在慢性炎症性疾病管理中的发现

Journal of Translational Autoimmunity

IF3.6

2025-10-310

OAAI

Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera

FEBS JOURNAL

IF4.2

2024-12-131

OAAI

SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

IF2.8

2024-11-010

OAAI

Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage

EBIOMEDICINE

IF10.8

2024-09-010

OAAI

McNeilly, Sarah; Thomson, Cameron R.; Gonzalez-Trueba, Laura; Sin, Yuan Yan; Granata, Alessandra; Hamilton, Graham; Lee, Michelle; Boland, Erin; McClure, John D.; Lumbreras-Perales, Cristina; Aman, Alisha; Kumar, Apoorva A.; Cantini, Marco; Gok, Caglar; Graham, Delyth; Tomono, Yasuko; Anderson, Christopher D.; Lu, Yinhui; Smith, Colin; Markus, Hugh S.; Abramowicz, Marc; Vilain, Catheline; Salman, Rustam Al-Shahi; Salmeron-Sanchez, Manuel; Hainsworth, Atticus H.; Fuller, William; Kadler, Karl E.; Bulleid, Neil J.; Van Agtmael, Tom

Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability

FEBS LETTERS

IF3

2024-05-092