孔

孔建强 (Jian-Qiang Kong)

Chinese Academy of Medical Sciences and Peking Union Medical College邮箱:jianqiangk@imm.ac.cn

H指数:19

被引数:1,564

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荣誉奖项

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Glycosylation switches spiramycin from an antibiotic to a hepatoprotective agent by targeting GSTP1

糖基化通过靶向GSTP1将螺旋霉素从抗生素转变为肝保护剂

Bioorganic Chemistry

IF4.7

2026-08-280

PRE

Convergent Evolution and De Novo Reconstitution of Apiin Biosynthesis

PLANT BIOTECHNOLOGY JOURNAL

IF10.5

2025-12-010

OAAI

The clarification of two hydroxylation steps in the conversion of cholesterol to OSW-1 in Ornithogalum saundersiae

在Ornithogalum saundersiae中胆固醇转化为OSW-1过程中两个羟基化步骤的阐明

Plant Biotechnology Journal

IF10.5

2025-06-220

OAAI

A promiscuous xyloglucan xylosyltransferase 1 (OsaXXT1) from Ornithogalum saundersiae recognizes both cello-oligosaccharides and nonsaccharide lignans

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2024-04-010

PRE

Green acetyl modification of puerarin to form puerarin 6′′-O-acetate using engineered Escherichia coli with favorable pathways and elevated acetyl-CoA supply

GREEN CHEMISTRY

IF9.2

2024-01-011

PRE

Exploring 3-O-glycosylations of 20(R)-dammarane ginsenosides and the catalytic mechanism underlying the stereoselectivity with the combined assistance of AlphaFold 2 and molecular docking

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

IF8.5

2024-01-010

PRE

Protein Engineering of PhUGT, a Donor Promiscuous Glycosyltransferase, for the Improved Enzymatic Synthesis of Antioxidant Quercetin 3-O-N-Acetylgalactosamine

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IF6.2

2022-03-249

PRE

Glycodiversifying Testosterone with a Promiscuous Glycosyltransferase OsSGT2 from Ornithogalum saundersiae

ACS SYNTHETIC BIOLOGY

IF3.9

2021-11-305

PRE

Diacerein as a Promising Acyl Donor in Biosynthetic Acetyl-CoA and Glycosyl Esters Mediated by a Multifunctional Maltose O-Acetyltransferase from Escherichia coli

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IF6.2

2021-06-035

PREAI

Altering the Regioselectivity of Cytochrome P450 BM3 Variant M13 toward Genistein through Protein Engineering and Variation of Reaction Conditions

ACS OMEGA

IF4.3

2020-12-0211

OAAI

OcUGT1-Catalyzing Glycodiversification of Steroids through Glucosylation and Transglucosylation Actions

MOLECULES

IF4.6

2020-01-2210

OAAI

Structure and bioactivity of cholestane glycosides from the bulbs of Ornithogalum saundersiae Baker

PHYTOCHEMISTRY

IF3.4

2019-08-0116

PREAI

Characterization of two flavonol synthases with iron-independent flavanone 3-hydroxylase activity from Ornithogalum caudatum Jacq

BMC PLANT BIOLOGY

IF4.8

2019-05-1420

OAAI

OcUGT1-catalyzed glycosylation of testosterone with alternative donor substrates

PROCESS BIOCHEMISTRY

IF4

2018-10-015

PREAI

The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity

ACTA PHARMACEUTICA SINICA B

IF14.6

2018-10-0123

OAAI

OcUGT1-Catalyzed Glucosylation of Sulfuretin Yields Ten Glucosides

CATALYSTS

IF4

2018-09-254

OAAI

Probing and Engineering Key Residues for Bis-C-glycosylation and Promiscuity of a C-Glycosyltransferase

ACS CATALYSIS

IF13.1

2018-04-2343

PREAI

Isolation and characterization of a multifunctional flavonoid glycosyltransferase from Ornithogalum caudatum with glycosidase activity

SCIENTIFIC REPORTS

IF3.9

2018-04-1230

OAAI

Steroids hydroxylation catalyzed by the monooxygenase mutant 139-3 from Bacillus megaterium BM3

ACTA PHARMACEUTICA SINICA B

IF14.6

2017-07-0116

OAAI

Functional analyses of OcRhS1 and OcUER1 involved in UDP-L-rhamnose biosynthesis in Ornithogalum caudatum

PLANT PHYSIOLOGY AND BIOCHEMISTRY

IF5.7

2016-12-0125

PREAI

研究方向

植物天然药物合成生物学天然药物生物合成相关基因的分离、筛选及功能鉴定植物天然药物代谢工程菌的构建天然药物生物合成青蒿素前体紫穗槐-4,11-二烯和青蒿酸酵母工程菌的构建完成了金丝桃素大肠杆菌和酿酒酵母工程菌的构建紫杉醇前体紫杉烯大肠杆菌工程菌的构建工程菌发酵生产天然药物及其前体

H 指数:24论文数:146被引数:2,160

Ming Liu

H 指数:39论文数:544被引数:6,487

Yujia Sun

H 指数:18论文数:58被引数:1,582

刘

刘星

H 指数:39论文数:214被引数:5,684

贺

贺玖明

H 指数:40论文数:177被引数:5,802

Yiting Pan

H 指数:22论文数:87被引数:1,259