Benjamin P. Brown - Publications, H-index & Citations

Benjamin P. Brown

vanderbilt university

18H指数

81论文数

1.4K被引数

收录论文 22

发表时间

Modeling protein conformational ensembles by guiding AlphaFold2 with Double Electron Electron Resonance (DEER) distance distributions 通过双电子电子共振（DEER）距离分布引导AlphaFold2，对蛋白质构象集合进行建模

Nature Communications

IF15.7

2025-08-02

OAAI

Tianqi Wu; Richard A. Stein; Te-Yu Kao; Benjamin Brown; Hassane S. Mchaourab

Interpretable Deep-Learning pK a Prediction for Small Molecule Drugs via Atomic Sensitivity Analysis

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2024-12-30

OAAI

Decorte, Joseph; Brown, Benjamin; Jeffrey, Rathmell; Meiler, Jens

Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-06-07

OAAI

Jones, Caleb A. H.; Brown, Benjamin P.; Schultz, Daniel C.; Engers, Julie; Kramlinger, Valerie M.; Meiler, Jens; Lindsley, Craig W.

Characterization of EGFR ectodomain mutation in acquired resistance to cetuximab in colorectal cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Joshi, Neeraj; Deal, Ramona Graves; Bogatcheva, Galina; Higginbotham, James N.; Ramirez, Marisol; Brown, Benjamin P.; Liu, Qi; Meiler, Jens; Singh, Bhuminder

Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations

JOURNAL OF CHEMICAL THEORY AND COMPUTATION

IF5.5

2024-01-12

OAAI

Brown, Benjamin P.; Stein, Richard A.; Meiler, Jens; Mchaourab, Hassane S.

Acquired Secondary HER2 Mutations Enhance HER2/MAPK Signaling and Promote Resistance to HER2 Kinase Inhibition in Breast Cancer

CANCER RESEARCH

IF16.6

2023-07-05

PREAI

Marin, Arnaldo; Al Mamun, Abdullah; Patel, Hima; Akamatsu, Hiroaki; Ye, Dan; Sudhan, Dhivya R.; Eli, Lisa; Marcelain, Katherine; Brown, Benjamin P.; Meiler, Jens; Arteaga, Carlos L.; Hanker, Ariella B.

Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6

ACS CHEMICAL BIOLOGY

IF3.8

2023-04-07

OAAI

Christianson, David W.; Watson, Paris R.; Gupta, Suchetana; Hosseinzadeh, Parisa; Brown, Benjamin P.; Baker, David

Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer 肺癌中EGFR外显子19缺失突变的等位基因特异性激活，酶动力学和抑制剂敏感性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2022-07-22

OAAI

Brown, Benjamin P.; Zhang, Yun-Kai; Kim, Soyeon; Finneran, Patrick; Yan, Yingjun; Du, Zhenfang; Kim, Jiyoon; Hartzler, Abigail Leigh; LeNoue-Newton, Michele L.; Smith, Adam W.; Meiler, Jens; Lovly, Christine M.

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

NATURE COMMUNICATIONS

IF15.7

2022-06-08

OAAI

Bozhanova, Nina G.; Flyak, Andrew, I; Brown, Benjamin P.; Ruiz, Stormy E.; Salas, Jordan; Rho, Semi; Bombardi, Robin G.; Myers, Luke; Soto, Cinque; Bailey, Justin R.; Crowe, James E.; Bjorkman, Pamela J.; Meiler, Jens

The sector-level safety net provided by the current mix of farm programs

APPLIED ECONOMIC PERSPECTIVES AND POLICY

IF3.4

2022-04-20

OAAI

Westhoff, Patrick; Rosenbohm, Marc; Kim, Youngjune; Brown, Benjamin

A Review of Embodied Carbon in Landscape Architecture. Practice and Policy

C-JOURNAL OF CARBON RESEARCH

IF2.9

2022-03-26

OAAI

Nikologianni, Anastasia; Plowman, Theodoros; Brown, Benjamin

A spectrum of secondary mutations in HER2 augment breast cancer cell growth and reduce neratinib sensitivity in HER2-mutant breast cancer

CANCER RESEARCH

IF16.6

2022-02-15

PREAI

Marin, Arnaldo Andres; Al Mamun, Abdullah; Akamatsu, Hiroaki; Ye, Dan; Sudhan, Dhivya; Brown, Benjamin; Brewer, Monica Red; Eli, Lisa; Meiler, Jens; Arteaga, Carlos L.; Hanker, Ariella B.

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5' Leader Pre-tRNA Recognition

FRONTIERS IN MOLECULAR BIOSCIENCES

IF4

2021-09-03

OAAI

Zeng, Danyun; Abzhanova, Ainur; Brown, Benjamin P.; Reiter, Nicholas J.

Structure-function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting

NATURE COMMUNICATIONS

IF15.7

2021-03-02

OAAI

Du, Zhenfang; Brown, Benjamin P.; Kim, Soyeon; Ferguson, Donna; Pavlick, Dean C.; Jayakumaran, Gowtham; Benayed, Ryma; Gallant, Jean-Nicolas; Zhang, Yun-Kai; Yan, Yingjun; Red-Brewer, Monica; Ali, Siraj M.; Schrock, Alexa B.; Zehir, Ahmet; Ladanyi, Marc; Smith, Adam W.; Meiler, Jens; Lovly, Christine M.

General Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2021-01-26

OAAI

Brown, Benjamin P.; Mendenhall, Jeffrey; Geanes, Alexander R.; Meiler, Jens

BCL::Conf: Improved Open-Source Knowledge-Based Conformation Sampling Using the Crystallography Open Database

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2020-12-22

OAAI

Mendenhall, Jeffrey; Brown, Benjamin P.; Kothiwale, Sandeepkumar; Meiler, Jens

Lipocalin Blc is a potential heme-binding protein

FEBS LETTERS

IF3

2020-12-03

OAAI

Bozhanova, Nina G.; Calcutt, M. Wade; Beavers, William N.; Brown, Benjamin P.; Skaar, Eric P.; Meiler, Jens

EGFR kinase domain duplication (EGFR-KDD) is activated by asymmetric intramolecular dimerization

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Du, Zhenfang; Gallant, Jean-Nicolas; Red-Brewer, Monica; Brown, Benjamin; Sheehan, Jonathan; Meiler, Jens; Lovly, Christine M.

On-target resistance to mutant selective EGFR inhibitors develops in an allele-specific manner dependent on the original EGFR activating mutation

CANCER RESEARCH

IF16.6

2019-07-01

PREAI

Zhang, Yunkai; Brown, Benjamin P.; Westover, David; Yan, Yingjun; Qiao, Huan; Huang, Vincent; Du, Zhenfang; Smith, Jarrod A.; Ross, Jeffrey S.; Miller, Vincent A.; Ali, Siraj; Bazhenova, Lyudmila; Schrock, Alexa B.; Meiler, Jens; Lovly, Christine M.

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation 对突变选择性EGFR抑制剂奥希替尼的靶向耐药可以等位基因特异性方式发展，依赖于原始EGFR激活突变

CLINICAL CANCER RESEARCH

IF10.2

2019-06-03

OAAI

Brown, Benjamin P.; Zhang, Yun-Kai; Westover, David; Yan, Yingjun; Qiao, Huan; Huang, Vincent; Du, Zhenfang; Smith, Jarrod A.; Ross, Jeffrey S.; Miller, Vincent A.; Ali, Siraj; Bazhenova, Lyudmila; Schrock, Alexa B.; Meiler, Jens; Lovly, Christine M.

研究方向