Alexander J. Dear - Publications, H-index & Citations

Alexander J. Dear

lund university

22H指数

65论文数

1.8K被引数

收录论文 32

发表时间

Structural defects in amyloid-β fibrils drive secondary nucleation 淀粉样蛋白β纤维的结构缺陷驱动二次成核

Nature Communications

IF15.7

2026-02-18

OAAI

Jing Hu; Tom Scheidt; Dev Thacker; Emil Axell; Elin Stemme; Urszula Łapińska; Stefan Wennmalm; Georg Meisl; Samo Curk; Maria Andreasen; Michele Vendruscolo; Paolo Arosio; Anđela Šarić; Jeremy D. Schmit; Tuomas P. J. Knowles; Emma Sparr; Sara Linse; Thomas C. T. Michaels; Alexander J. Dear

General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta coaggregation 复杂自组装反应的通用积分速率定律揭示了Amyloid-beta共聚集的机制

Phys. Chem. Chem. Phys.

IF2.9

2025-10-01

PREAI

Alexander J. Dear; Georg Meisl; Emil Axell; Xiaoting Yang; Risto Cukalevski; Thomas C. T. Michaels; Sara Linse; L. Mahadevan

Approximate Lie symmetries and singular perturbation theory 近似李对称性与奇异摄动理论

PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

IF3

2025-04-16

PREAI

Dear, Alexander J.

Kinetics of Amyloid Oligomer Formation 淀粉样寡聚体形成的动力学

ANNUAL REVIEW OF BIOPHYSICS

IF13.7

2025-02-10

PREAI

Wei, Jiapeng; Meisl, Georg; Dear, Alexander J.; Michaels, Thomas C. T.; Knowles, Tuomas P. J.

α-Synuclein oligomers form by secondary nucleation

NATURE COMMUNICATIONS

IF15.7

2024-08-17

OAAI

Xu, Catherine K.; Meisl, Georg; Andrzejewska, Ewa A.; Krainer, Georg; Dear, Alexander J.; Castellana-Cruz, Marta; Turi, Soma; Edu, Irina A.; Vivacqua, Giorgio; Jacquat, Raphael P. B.; Arter, William E.; Spillantini, Maria Grazia; Vendruscolo, Michele; Linse, Sara; Knowles, Tuomas P. J.

The role of shear forces in primary and secondary nucleation of amyloid fibrils 剪切力在淀粉样蛋白原纤维的初级和次级成核中的作用

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-06-14

OAAI

Axell, Emil; Hu, Jing; Lindberg, Max; Dear, Alexander J.; Ortigosa-Pascual, Lei; Andrzejewska, Ewa A.; Sneideriene, Greta; Thacker, Dev; Knowles, Tuomas P. J.; Sparr, Emma; Linse, Sara

Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-05-24

OAAI

Dear, Alexander J.; Thacker, Dev; Wennmalm, Stefan; Ortigosa-Pascual, Lei; Andrzejewska, Ewa A.; Meisl, Georg; Linse, Sara; Knowles, Tuomas P. J.

Maximum entropy determination of mammalian proteome dynamics 哺乳动物蛋白质组动力学的最大熵测定

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-04-23

OAAI

Dear, Alexander J.; Garcia, Gonzalo A.; Meisl, Georg; Collins, Galen A.; Knowles, Tuomas P. J.; Goldberg, Alfred L.

Surface effects on functional amyloid formation 表面效应对功能性淀粉样蛋白形成的影响

NANOSCALE

IF5.1

2024-01-01

PREAI

Dear, Alexander J.; Meisl, Georg; Taylor, Christopher G.; Palmiero, Umberto Capasso; Stubbe, Susanne Nordby; Liu, Qian; Arosio, Paolo; Linse, Sara; Knowles, Tuomas P. J.; Andreasen, Maria

Kinetic models reveal the interplay of protein production and aggregation

CHEMICAL SCIENCE

IF7.4

2024-01-01

OAAI

Wei, Jiapeng; Meisl, Georg; Dear, Alexander; Oosterhuis, Matthijs; Melki, Ronald; Emanuelsson, Cecilia; Linse, Sara; Knowles, Tuomas P. J.

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed

CHEMICAL SCIENCE

IF7.4

2024-01-01

OAAI

Dear, Alexander J.; Teng, Xiangyu; Ball, Sarah R.; Lewin, Joshua; Horne, Robert I.; Clow, Daniel; Stevenson, Alisdair; Harper, Natasha; Yahya, Kim; Yang, Xiaoting; Brewerton, Suzanne C.; Thomson, John; Michaels, Thomas C. T.; Linse, Sara; Knowles, Tuomas P. J.; Habchi, Johnny; Meisl, Georg

Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation

ACS CHEMICAL NEUROSCIENCE

IF3.9

2022-11-21

OAAI

Thacker, Dev; Willas, Amanda; Dear, Alexander J.; Linse, Sara

Kinetic profiling of therapeutic strategies for inhibiting the formation of amyloid oligomers

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2022-04-25

OAAI

Michaels, Thomas C. T.; Dear, Alexander J.; Cohen, Samuel I. A.; Vendruscolo, Michele; Knowles, Tuomas P. J.

Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation

CHEMICAL SCIENCE

IF7.4

2022-01-01

OAAI

Braun, Gabriel A.; Dear, Alexander J.; Sanagavarapu, Kalyani; Zetterberg, Henrik; Linse, Sara

Feedback control of protein aggregation

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2021-08-09

PREAI

Dear, Alexander J.; Michaels, Thomas C. T.; Knowles, Tuomas P. J.; Mahadevan, L.

On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide

BIOMACROMOLECULES

IF5.4

2020-11-10

PREAI

Braun, Gabriel A.; Ary, Beatrice E.; Dear, Alexander J.; Rohn, Matthew C. H.; Payson, Abigail M.; Lee, David S. M.; Parry, Robert C.; Friedman, Connie; Knowles, Tuomas P. J.; Linse, Sara; Akerfeldt, Karin S.

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2020-08-10

PREAI

Flagmeier, Patrick; De, Suman; Michaels, Thomas C. T.; Yang, Xiaoting; Dear, Alexander J.; Emanuelsson, Cecilia; Vendruscolo, Michele; Linse, Sara; Klenerman, David; Knowles, Tuomas P. J.; Dobson, Christopher M.

Kinetic diversity of amyloid oligomers 淀粉样蛋白寡聚体的动力学多样性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-05-15

120

OAAI

Dear, Alexander J.; Michaels, Thomas C. T.; Meisl, Georg; Klenerman, David; Wu, Si; Perrett, Sarah; Linse, Sara; Dobson, Christopher M.; Knowles, Tuomas P. J.

Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

NATURE CHEMISTRY

IF20.2

2020-04-13

233

OAAI

Michaels, Thomas C. T.; Saric, Andela; Curk, Samo; Bernfur, Katja; Arosio, Paolo; Meisl, Georg; Dear, Alexander J.; Cohen, Samuel I. A.; Dobson, Christopher M.; Vendruscolo, Michele; Linse, Sara; Knowles, Tuomas P. J.

The catalytic nature of protein aggregation

JOURNAL OF CHEMICAL PHYSICS

IF3.1

2020-01-28

OAAI

Dear, Alexander J.; Meisl, Georg; Michaels, Thomas C. T.; Zimmermann, Manuela R.; Linse, Sara; Knowles, Tuomas P. J.

研究方向