未登录 Synthetic lethality of mRNA quality control complexes in cancer mRNA质量控制复合物在癌症中的合成致死率 Prindle, Vivian; Richardson, Adam E.; Sher, Kimberly R.; Kongpachith, Sarah; Kentala, Kaitlin; Petiwala, Sakina; Cheng, Dong; Widomski, Deborah; Le, Phuong; Torrent, Maricel; Chen, Anlu; Walker, Stephen; Palczewski, Marianne B.; Mitra, Diya; Manaves, Vlasios; Shi, Xu; Lu, Charles; Sandoval, Stephanie; Dezso, Zoltan; Buchanan, F. Gregory; Verduzco, Daniel; Bierie, Brian; Meulbroek, Jonathan A.; Pappano, William N.; Plotnik, Joshua P. 分享 收藏
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Inhibition of MALT1 and BCL2 Induces Synergistic Antitumor Activity in Models of B-Cell Lymphoma Plotnik, Joshua P.; Richardson, Adam E.; Yang, Haopeng; Rojas, Estela; Bontcheva, Velitchka; Dowell, Colleen; Parsons, Sydney; Wilson, Ashley; Ravanmehr, Vida; Will, Christine; Jung, Paul; Zhu, Haizhong; Partha, Sarathy Karunan; Panchal, Sanjay C.; Mali, Raghuveer Singh; Kohlhapp, Frederick J.; Mcclure, Ryan A.; Ramathal, Cyril Y.; George, Mariam D.; Jhala, Manisha; Elsen, Nathaniel L.; Qiu, Wei; Judge, Russell A.; Pan, Chin; Mastracchio, Anthony; Henderson, Jared; Meulbroek, Jonathan A.; Green, Michael R.; Pappano, William N. 分享 收藏
MALT1 protease inhibition overcomes BTK inhibitor resistance and shows synergistic activity with venetoclax in models of B cell lymphoma and leukemia Plotnik, Joshua P.; Mali, Raghuveer S.; Bontcheva, Velitchka; Dowell, Colleen; Chen, Jun; Richardson, Adam E.; McClure, Ryan A.; Jung, Paul; Pham, Lan; Souers, Andrew J.; Meulbroek, Jonathan A.; Pappano, William N. 分享 收藏
Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues Steiglitz, BM; Kreider, JM; Frankenburg, EP; Pappano, WN; Hoffman, GG; Meganck, JA; Liang, XW; Höök, M; Birk, DE; Goldstein, SA; Greenspan, DS 分享 收藏
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The HPK1 Inhibitor A-745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy Malchow, Sven; Korepanova, Alla; Panchal, Sanjay C.; McClure, Ryan A.; Longenecker, Kenton L.; Qiu, Wei; Zhao, Hongyu; Cheng, Min; Guo, Jun; Klinge, Kelly L.; Trusk, Patricia; Pratt, Steven D.; Li, Tao; Kurnick, Matthew D.; Duan, Lishu; Shoemaker, Alex R.; Gopalakrishnan, Sujatha M.; Warder, Scott E.; Shotwell, J. Brad; Lai, Albert; Sun, Chaohong; Osuma, Augustine T.; Pappano, William N. 分享 收藏
Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade Kohlhapp, Frederick J.; Haribhai, Dipica; Mathew, Rebecca; Duggan, Ryan; Ellis, Paul A.; Wang, Rui; Lasater, Elisabeth A.; Shi, Yan; Dave, Nimita; Riehm, Jacob J.; Robinson, Valerie A.; Do, An D.; Li, Yijin; Orr, Christine J.; Sampath, Deepak; Raval, Aparna; Merchant, Mark; Bhathena, Anahita; Salem, Ahmed Hamed; Hamel, Keith M.; Leverson, Joel D.; Donawho, Cherrie; Pappano, William N.; Uziel, Tamar 分享 收藏
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex (vol 13, pg 389, 2017) He, Yupeng; Selvaraju, Sujatha; Curtin, Michael L.; Jakob, Clarissa G.; Zhu, Haizhong; Comess, Kenneth M.; Shaw, Bailin; The, Juliana; Lima-Fernandes, Evelyne; Szewczyk, Magdalena M.; Cheng, Dong; Klinge, Kelly L.; Li, Huan-Qiu; Pliushchev, Marina; Algire, Mikkel A.; Maag, David; Guo, Jun; Dietrich, Justin; Panchal, Sanjay C.; Petros, Andrew M.; Sweis, Ramzi F.; Torrent, Maricel; Bigelow, Lance J.; Senisterra, Guillermo; Li, Fengling; Kennedy, Steven; Wu, Qin; Osterling, Donald J.; Lindley, David J.; Gao, Wenqing; Galasinski, Scott; Barsyte-Lovejoy, Dalia; Vedadi, Masoud; Buchanan, Fritz G.; Arrowsmith, Cheryl H.; Chiang, Gary G.; Sun, Chaohong; Pappano, William N. 分享 收藏
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex He, Yupeng; Selvaraju, Sujatha; Curtin, Michael L.; Jakob, Clarissa G.; Zhu, Haizhong; Comess, Kenneth M.; Shaw, Bailin; The, Juliana; Lima-Fernandes, Evelyne; Szewczyk, Magdalena M.; Cheng, Dong; Klinge, Kelly L.; Li, Huan-Qiu; Pliushchev, Marina; Algire, Mikkel A.; Maag, David; Guo, Jun; Dietrich, Justin; Panchal, Sanjay C.; Petros, Andrew M.; Sweis, Ramzi F.; Torrent, Maricel; Bigelow, Lance J.; Senisterra, Guillermo; Li, Fengling; Kennedy, Steven; Wu, Qin; Osterling, Donald J.; Lindley, David J.; Gao, Wenqing; Galasinski, Scott; Barsyte-Lovejoy, Dalia; Vedadi, Masoud; Buchanan, Fritz G.; Arrowsmith, Cheryl H.; Chiang, Gary G.; Sun, Chaohong; Pappano, William N. 分享 收藏
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity Bromberg, Kenneth D.; Mitchell, Taylor R. H.; Upadhyay, Anup K.; Jakob, Clarissa G.; Jhala, Manisha A.; Comess, Kenneth M.; Lasko, Loren M.; Li, Conglei; Tuzon, Creighton T.; Dai, Yujia; Li, Fengling; Eram, Mohammad S.; Nuber, Alexander; Soni, Niru B.; Manaves, Vlasios; Algire, Mikkel A.; Sweis, Ramzi F.; Torrent, Maricel; Schotta, Gunnar; Sun, Chaohong; Michaelides, Michael R.; Shoemaker, Alex R.; Arrowsmith, Cheryl H.; Brown, Peter J.; Santhakumar, Vijayaratnam; Martin, Alberto; Rice, Judd C.; Chiang, Gary G.; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Pappano, William N. 分享 收藏
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8 Judge, Russell A.; Zhu, Haizhong; Upadhyay, Anup K.; Bodelle, Pierre M.; Hutchins, Charles W.; Torrent, Maricel; Marin, Violeta L.; Yu, Wenyu; Vedadi, Masoud; Li, Fengling; Brown, Peter J.; Pappano, William N.; Sun, Chaohong; Petros, Andrew M. 分享 收藏
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Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification Wang, Jieyi; Goetsch, Liliane; Tucker, Lora; Zhang, Qian; Gonzalez, Alexandra; Vaidya, Kedar S.; Oleksijew, Anatol; Boghaert, Erwin; Song, Minghao; Sokolova, Irina; Pestova, Ekaterina; Anderson, Mark; Pappano, William N.; Ansell, Peter; Bhathena, Anahita; Naumovski, Louie; Corvaia, Nathalie; Reilly, Edward B. 分享 收藏
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor Xiao, Yu; Nimmer, Paul; Sheppard, George S.; Bruncko, Milan; Hessler, Paul; Lu, Xin; Roberts-Rapp, Lisa; Pappano, William N.; Elmore, Steven W.; Souers, Andrew J.; Leverson, Joel D.; Phillips, Darren C. 分享 收藏
Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2 A-893的发现，一种新的细胞活性的赖氨酸甲基转移酶SMYD2的苯并恶嗪酮抑制剂 Sweis, Ramzi F.; Wang, Zhi; Algire, Mikkel; Arrowsmith, Cheryl H.; Brown, Peter J.; Chiang, Gary G.; Guo, Jun; Jakob, Clarissa G.; Kennedy, Steven; Li, Fengling; Maag, David; Shaw, Bailin; Soni, Nirupama B.; Vedadi, Masoud; Pappano, William N. 分享 收藏
Discovery of A-366, a novel small molecule inhibitor that uncovers an unappreciated role for G9a/GLP in the epigenetics of leukemia Guo, Jun; Pliushchev, Marina; He, Yupeng; Ferguson, Debra; Jagadeeswaran, Sujatha; Petros, Andrew; Sun, Chaohong; Soni, Niru B.; Shaw, Bailin; Korepanova, Alla; Maag, David; Sweis, Ramzi; Buchanan, Fritz G.; Michaelides, Michael; Shoemaker, Alex; Tse, Chris; Chiang, Gary G.; Pappano, William N. 分享 收藏
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Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a 组蛋白甲基转移酶G9a的有效和选择性抑制剂的发现和开发 Sweis, Ramzi F.; Pliushchev, Marina; Brown, Peter J.; Guo, Jun; Li, Fengling; Maag, David; Petros, Andrew M.; Soni, Nirupama B.; Tse, Chris; Vedadi, Masoud; Michaelides, Michael R.; Chiang, Gary G.; Pappano, William N. 分享 收藏
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