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J

James L. Kirkland

Mayo Clinic
H指数:111
被引数:5.9万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial

代谢功能障碍相关脂肪性肝炎中的 senolytics 达沙替尼和槲皮素：一项概念验证随机对照试验

Nature Metabolism
IF20.8
2026-10-010
OAAI
Mijra Koning; Artemiy Kovynev; Marcos F. Fondevila; Eliza J. M. Ruhe; Michiel C. Mommersteeg; Christian Ramakers; Barbara A. Hutten; Bart Verwer; Marije Vlug; Teaco Kuiper; Maarten van den Berg; Anne Vrieze; Maurice Bizino; Annewieke van den Beld; Luuk Berk; Thomas Boerlage; Quinten J. J. Augustijn; Willem Pieter Brouwer; Weena J. Chen; Djuna Cahen; Robert Verdonk; Wouter J. de Jonge; Sandjai Ramsoekh; Michail Doukas; Sanne M. M. Vermorgen; Joanne Verheij; Ulrich Beuers; R. B. Takkenberg; Jacques J. G. Bergman; Geert R. A. M. D’Haens; Joost P. H. Drenth; Tamar Tchkonia; Bernd Schnabl; James L. Kirkland; Abraham S. Meijnikman
Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures

对临床和新双膦酸盐反应的多组学分析揭示了其对与年龄相关标志物的骨骼外影响

Signal Transduction and Targeted Therapy
IF52.7
2026-07-150
OAAI
Jinsen Lu; Srinivasa Rao Rao; Helen Knowles; Haoqun Zhan; Beatriz Gamez; Mingyu Qin; Eleanor Platt; Lucy R. Frost; Tiffany-Jayne Allen; Gayle Marshall; Kilian V. M. Huber; Ludwig G. Bauer; Iolanda Vendrell; Darragh P. O’Brien; Benedikt Kessler; Anne Horne; Ian R. Reid; Chas Bountra; James L. Kirkland; Sundeep Khosla; Frank H. Ebetino; Emilio Roldan; R. Graham G. Russell; James R. Edwards
Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

作者更正：化疗的疗效受限于表达PD-L2的肿瘤内衰老细胞

Nature Cancer
IF28.5
2026-05-290
OAAI
Selim Chaib; José Alberto López-Domínguez; Marta Lalinde-Gutiérrez; Neus Prats; Ines Marin; Olga Boix; Andrea García-Garijo; Kathleen Meyer; María Isabel Muñoz; Mònica Aguilera; Lidia Mateo; Camille Stephan-Otto Attolini; Susana Llanos; Sandra Pérez-Ramos; Marta Escorihuela; Fatima Al-Shahrour; Timothy P. Cash; Tamara Tchkonia; James L. Kirkland; María Abad; Alena Gros; Joaquín Arribas; Manuel Serrano
Senloytics, dasatinib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease

Senloyatics，达沙替尼加槲皮素，减少肾脏炎症，衰老细胞丰度和损伤，同时恢复小鼠糖尿病肾病的老年保护因子

eBioMedicine
IF10.8
2026-01-200
OAAI
Xiaohui Bian; Zachary K. Snow; Caroline J. Zinn; Anastasia L. Bratulin; Khaled M. Elhusseiny; Tamar Tchkonia; James L. Kirkland; Yi Zhu; Sundeep Khosla; Seo Rin Kim; Lilach O. Lerman; LaTonya J. Hickson
Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF

清除衰老细胞的药物疗法可减轻炎症、内皮损伤和HFpEF患者的心脏纤维化。

CARDIOVASCULAR RESEARCH
IF13.3
2025-12-011
OAAI
Silva, Elsa D.; Tome, Ines; Vasques-Novoa, Francisco; Conceicao, Gloria; Silva, Andreia; Barros, Antonio S.; Mendes-Ferreira, Pedro; Santos-Ribeiro, Diana; Goncalves, Alexandre; Angelico-Goncalves, Antonio; Adao, Rui; Caetano, Carolina; Sousa, Daniel; Miranda-Silva, Daniela; Juni, Rio P.; Tchkonia, Tamara; Kirkland, James L.; Caramelo, Francisco; Goncalves, Nadia; Sampaio-Pinto, Vasco; Ribeiro, Joao S.; Boon, Reinier A.; Leite-Moreira, Adelino; Pitrez, Patricia; Pinto-do-O, Perpetua; Santos, Susana G.; Falcao-Pires, Ines; Ferreira, Lino; Nascimento, Diana S.
Advancing biological understanding of cellular senescence with computational multiomics

通过计算多组学推进对细胞衰老的生物学理解

Nature Genetics
IF0
2025-09-150
PRE
Sheng Li; Paula A. Agudelo Garcia; Constantin Aliferis; Michael J. Becich; Jazmin Calyeca; Benjamin D. Cosgrove; Jennifer Elisseeff; Negin Farzad; Elana J. Fertig; Carolyn Glass; Liangcai Gu; Qianjiang Hu; Zhicheng Ji; Melanie Königshoff; Nathan K. LeBrasseur; Dongmei Li; Anjun Ma; Qin Ma; Vilas Menon; Jacob T. Mitchell; Ana L. Mora; Sushma Nagaraj; Andrew C. Nelson; Laura J. Niedernhofer; Mauricio Rojas; Hash Brown Taha; Jinhua Wang; Siyuan Wang; Pei-Hsun Wu; Jichun Xie; Ming Xu; Miao Yu; Xu Zhang; Yue Zhao; Peter D. Adams; Cristina Aguayo-Mazzucato; Darren J. Baker; Christopher Benz; David A. Bernlohr; Marta Bueno; Jin Chen; Bennett G. Childs; Jeffrey H. Chuang; Dongjun Chung; Mythili Dileepan; Li Ding; Mingze Dong; Francesca Duncan; Archibald Enninful; William F. Flynn; Ana Catarina Franco; David Furman; Vesna Garovic; Stephanie Halene; Allison B. Herman; Ann V. Hertzel; Kanako Iwasaki; Hyeongseon Jeon; Jeon Woong Kang; Shilpita Karmakar; James L. Kirkland; Ron Korstanje; Erich Kummerfeld; Jun Hee Lee; Yang Liu; Yao Lu; Jose Lugo-Martinez; Helene Martini; Simon Melov; Nicolas Musi; João F. Passos; Samuel T. Peters; Irfan Rahman; Ramalakshmi Ramasamy; Alexandra N. Rindone; Paul D. Robbins; Paul Robson; Jhonny Rodriguez-Lopez; Lorena Rosas; Nadia Rosenthal; Marissa J. Schafer; Birgit Schilling; Elizabeth L. Schmidt; Kevin Schneider; Kaustav Sengupta; Jian Shu; Peter T. C. So; Li Sun; Tamar Tchkonia; Marcos G. Teneche; Natalia Vanegas; Julia Wang; Juan Xie; Shanshan Yin; Ke Zhang; Quan Zhu; Rong Fan
A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer's disease

一项关于清除衰老细胞药物以改善阿尔茨海默病风险老年人群认知和活动能力的初步研究

EBIOMEDICINE
IF10.8
2025-03-011
OAAI
Millar, Courtney L.; Iloputaife, Ike; Baldyga, Kathryn; Norling, Amani M.; Boulougoura, Afroditi; Vichos, Theodoros; Tchkonia, Tamara; Deisinger, Aaron; Pirtskhalava, Tamar; Kirkland, James L.; Travison, Thomas G.; Lipsitz, Lewis A.

研究方向

暂未获取到该数据
T
Tamar Tchkonia
H 指数:94论文数:344被引数:4.8万
N
Nathan K. LeBrasseur
H 指数:78论文数:324被引数:3.3万
T
Tamar Pirtskhalava
H 指数:36论文数:98被引数:1.8万
朱
朱益
H 指数:39论文数:74被引数:1.7万
S
Sundeep Khosla
H 指数:136论文数:754被引数:8.1万
L
Laura J. Niedernhofer
H 指数:80论文数:309被引数:3.0万
P
Paul D. Robbins
H 指数:123论文数:737被引数:7.2万
A
Allyson K. Palmer
H 指数:24论文数:66被引数:1.0万
N
Nino Giorgadze
H 指数:26论文数:72被引数:1.2万
徐
徐明
H 指数:39论文数:218被引数:1.3万