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D

David E. Sleat

Rutgers University

H指数:44

被引数:6,595

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Elevated tripeptidyl-peptidase 1 corrects multiple phenotypes of disease in a mouse model of juvenile neuronal ceroid lipofuscinosis

升高的三肽基肽酶1纠正幼年神经元蜡样脂褐质沉积症小鼠模型中的多种疾病表型

Molecular Therapy Methods & Clinical Development

IF4.7

2025-09-030

OAAI

Cerebrospinal Fluid Protein Biomarker Discovery in CLN3

JOURNAL OF PROTEOME RESEARCH

IF3.6

2023-06-202

OA

Thermal Stability of Animal Orthologs of the Lysosomal Protease Tripeptidyl-peptidase 1 Does Not Correlate with Cellular Half-life: Implications for Evolutionary Redesign of the Human Enzyme

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-010

OAAI

Elevated levels of tripeptidyl peptidase 1 do not ameliorate pathogenesis in a mouse model of Alzheimer disease

三肽基肽酶1水平升高不能改善阿尔茨海默病小鼠模型的发病机制

NEUROBIOLOGY OF AGING

IF3.5

2022-10-013

OAAI

Novel Polyanionic Tracts Improve Expression of a TPP1:K16ApoE Chimera

IF4.2

2022-05-130

PRE

A Method to Estimate the Distribution of Proteins across Multiple Compartments Using Data from Quantitative Proteomics Subcellular Fractionation Experiments

JOURNAL OF PROTEOME RESEARCH

IF3.6

2022-05-060

PRE

Comparative Analysis of Quantitative Mass Spectrometric Methods for Subcellular Proteomics

JOURNAL OF PROTEOME RESEARCH

IF3.6

2020-03-0516

OA

Lysosomal protein thermal stability does not correlate with cellular half-life: global observations and a case study of tripeptidyl-peptidase 1

BIOCHEMICAL JOURNAL

IF4.3

2020-02-144

OA

Analysis of Brain and Cerebrospinal Fluid from Mouse Models of the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Changes in the Lysosomal Proteome

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2019-11-0130

OAAI

Proteomic Analysis of Brain and Cerebrospinal Fluid from the Three Major Forms of Neuronal Ceroid Lipofuscinosis Reveals Potential Biomarkers

来自三种主要形式的神经元类固醇脂褐质病的脑和脑脊液的蛋白质组学分析揭示了潜在的生物标志物

JOURNAL OF PROTEOME RESEARCH

IF3.6

2017-08-2838

OAAI

Using whole-exome sequencing to investigate the genetic bases of lysosomal storage diseases of unknown etiology

使用全外显子组测序研究病因不明的溶酶体贮积病的遗传基础

IF3.7

2017-07-256

OAAI

A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism

MOLECULAR THERAPY

IF12

2017-07-0121

OAAI

Accounting for Protein Subcellular Localization: A Compartmental Map of the Rat Liver Proteome

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2017-02-0170

OAAI

Effective Intravenous Therapy for Neurodegenerative Disease With a Therapeutic Enzyme and a Peptide That Mediates Delivery to the Brain

MOLECULAR THERAPY

IF12

2014-03-0149

OAAI

Extending the Mannose 6-Phosphate Glycoproteome by High Resolution/Accuracy Mass Spectrometry Analysis of Control and Acid Phosphatase 5-Deficient Mice

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2013-07-0145

OAAI

Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain

IF3.9

2012-11-2223

OA

Large-volume Intrathecal Enzyme Delivery Increases Survival of a Mouse Model of Late Infantile Neuronal Ceroid Lipofuscinosis

MOLECULAR THERAPY

IF12

2011-10-0158

OA

Classification of Subcellular Location by Comparative Proteomic Analysis of Native and Density-shifted Lysosomes

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2011-04-0138

OAAI

Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material

BIOCHEMICAL JOURNAL

IF4.3

2010-05-2713

OAAI

Acid phosphatase 5 removes the mannose 6-phosphate recognition marker from lysosomal proteins

MOLECULAR GENETICS AND METABOLISM

IF3.5

2010-02-010

PREAI