Discovery and Preclinical Pharmacology of NX-2127, an Orally Bioavailable Degrader of Bruton's Tyrosine Kinase with Immunomodulatory Activity for the Treatment of Patients with B Cell MalignanciesJOURNAL OF MEDICINAL CHEMISTRYIF6.82024-02-0121OA
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127ScienceIF45.82024-01-010OA
CHIMERIC AURORA A KINASE (AURKA) DEGRADERS EFFICIENTLY TARGET N-MYCNEURO-ONCOLOGYIF13.42023-06-120OAAI
NX-5948 promotes selective, sub-nanomolar degradation of inhibitor-resistant BTK mutantsCANCER RESEARCHIF16.62023-04-042PRE
Requirement for Class II Phosphoinositide 3-Kinase C2α in Maintenance of Glomerular Structure and FunctionMOLECULAR AND CELLULAR BIOLOGYIF2.72023-03-2060OAAI
NX-1607, A SMALL MOLECULE INHIBITOR OF THE CBL-B E3 UBIQUITIN LIGASE, PROMOTES T AND NK CELL ACTIVATION AND ENHANCES NK-MEDIATED ADCC IN A MOUSE LYMPHOMA TUMOR MODELJOURNAL FOR IMMUNOTHERAPY OF CANCERIF10.62022-11-071OA
NOTUM inhibition increases endocortical bone formation and bone strengthBONE RESEARCHIF152019-01-0861OAAI
Allosteric beta-blocker isolated from a DNA-encoded small molecule libraryPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12017-01-27128OAAI
Diacylglycerol lipase a knockout mice demonstrate metabolic and behavioral phenotypes similar to those of cannabinoid receptor 1 knockout miceFRONTIERS IN ENDOCRINOLOGYIF4.62015-06-0246OAAI
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypesBONE RESEARCHIF152014-10-28117OAAI
High-throughput screening of mouse knockout lines identifies true lean and obese phenotypesOBESITYIF4.72012-09-0656PREAI
Histopathological and Neurological Features of Atg4b Knockout MiceVETERINARY PATHOLOGYIF1.72010-07-1537PREAI
A mouse knockout library for secreted and transmembrane proteinsNATURE BIOTECHNOLOGYIF41.72010-06-20324PREAI
PTH stimulates bone formation in mice deficient in Lrp5JOURNAL OF BONE AND MINERAL RESEARCHIF5.92009-12-0492PREAI
Large-scale gene trapping in C57BL/6N mouse embryonic stem cellsGENOME RESEARCHIF5.52008-09-17134OAAI
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout micePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12007-07-10185OAAI
Severe retinal degeneration associated with disruption of semaphorin 4AINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEIF4.72004-08-0151PREAI
Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic interventionPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAIF9.12003-11-10323OAAI
Genetic profile of insertion mutations in mouse leukemias and lymphomasGENOME RESEARCHIF5.52000-02-0165OAAI
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