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T

Thierry Brun

University of Geneva

H指数:35

被引数:4,055

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In situ metabolomics reveals intra-islet metabolite changes upon in vivo stimulation of insulin secretion.

原位代谢组学揭示了在体内刺激胰岛素分泌时胰岛内代谢物的变化。

Journal of Biological Chemistry

IF3.9

2025-09-010

OAAI

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

IF10.2

2022-01-1217

OA

PAX4 Defines an Expandable β-Cell Subpopulation in the Adult Pancreatic Islet

PAX4定义了成人胰岛中可扩展的 β 细胞亚群

SCIENTIFIC REPORTS

IF3.9

2015-10-2736

OAAI

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets

致糖尿病的环境诱导线粒体转录组的特定变化和人胰岛的分化

HUMAN MOLECULAR GENETICS

IF3.2

2015-06-2935

OAAI

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

IF7.5

2012-10-1698

OAAI

Mitochondrial dysfunction in pancreatic β cells

胰腺 β 细胞的线粒体功能障碍

TRENDS IN ENDOCRINOLOGY AND METABOLISM

IF12.6

2012-09-01225

PRE

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

IF7.5

2011-05-2150

OAAI

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-02-01145

OAAI

Peroxisome proliferator-activated receptor α (PPARα) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

IF10.2

2009-11-1240

OA

Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-08-0184

OAAI

A focus on the role of Pax4 in mature pancreatic islet β-cell expansion and survival in health and disease

JOURNAL OF MOLECULAR ENDOCRINOLOGY

IF3.8

2007-11-2360

OAAI

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1

HUMAN MOLECULAR GENETICS

IF3.2

2007-11-0749

OAAI

The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells

IF7.3

2007-01-2940

PREAI

MAFA controls genes implicated in insulin biosynthesis and secretion

MAFA控制与胰岛素生物合成和分泌有关的基因

IF10.2

2006-12-06195

OAAI

Reply to comment on:: !Biason-Lauber A, !Boehm B, !Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4:: possible link to beta cell regenerative capacity.: Diabetologia 48:900-905

IF10.2

2005-08-262

OAAI

Association of childhood type 1 diabetes mellitus with a variant of PAX4:: possible link to beta cell regenerative capacity

IF10.2

2005-04-1562

OAAI

The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets

JOURNAL OF CELL BIOLOGY

IF6.4

2004-12-13156

OAAI

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2004-07-0176

OAAI

Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2003-09-01155

OAAI

Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription

IF10.2

2003-06-0145

OAAI