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M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors Smith, Kyle S.; Fischer, Tom T.; Han, Katie; Kostecka, Anna; Lin, Hong; Senfter, Daniel; Soliman, Taha; Stepien, Natalia; Volz, Stefanie; Schwarz, Nathalie; Wedig, Tatjana; Madlener, Sibylle; Haberler, Christine; Dhanda, Sandeep K.; Upadhyaya, Santhosh A.; Blackburn, Patrick R.; Schmook, Maria T.; De Bont, Judith; Haapasalo, Hannu; Dargvainiene, Justina; Leypoldt, Frank; Pfister, Stefan M.; Hulleman, Esther; Orr, Brent A.; Gajjar, Amar; Robinson, Giles W.; Haapasalo, Joonas; Nordfors, Kristiina; Gojo, Johannes; Pajtler, Kristian W.; Maass, Kendra K.; Northcott, Paul A. 分享 收藏
Toward reducing the risk of cerebellar mutism syndrome: consensus statement from the Posterior Fossa Society 为降低小脑缄默综合征风险：后颅窝学会共识声明 Toescu, Sebastian M.; Pizer, Barry; Gump, William; Aquilina, Kristian; Avula, Shivaram; Mallucci, Conor; Parks, Christopher; Carai, Andrea; Robinson, Giles; Aldave, Guillermo; Baird, Lissa; Niazi, Toba; Keating, Robert; Klimo Jr, Paul 分享 收藏
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Efficacy and tolerability of mirdametinib (PD-0325901) in children, adolescents, and young adults with recurrent/progressive low-grade glioma: update from the SJ901 (NCT04923126) phase 1/2 clinical trial 米拉达米替布（PD-0325901）在儿童、青少年和年轻成人复发/进展性低级别胶质瘤中的有效性和耐受性：来自SJ901（NCT04923126）I/II期临床试验的更新 Vinitsky, Anna; Bag, Asim K.; Chiang, Jason; Li, Quian; Lin, Tong; Hoehn, Mary Ellen; Edwards, Angela; Storment, Diana; Singh, Anjali; Larkin, Jennifer; Bakare, Deborah; Simpson, Raven; Bertrand, Kelsey C.; Bagchi, Aditi; Weber, Michael D.; Qaddoumi, Ibrahim; Moreira, Daniel; Robinson, Giles W. 分享 收藏
DIVERGENT MEDULLOBLASTOMA CHROMATIN STATES DISCLOSE KDM2B AS A SELECTIVE DEPENDENCY 分化型髓母细胞瘤染色质状态揭示KDM2B为选择性依赖 Tao, Ran; Erkek-Ozhan, Serap; Xu, Beisi; Matsui, Yurika; Mittal, Priya; Smith, Kyle; Li, Yiran; Gao, Qingsong; Darrow, Emily; Xu, Ruijie; Djekidel, Nadhir; Bajpai, Richa; Kumar, Rahul; Reilly, Colleen; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Bhanu, Natarajan; Gudenas, Brian; Paul, Leena; Lin, Hong; Lowe, Kim; Kutscher, Lena; Garcia, Benjamin; Pruett-Miller, Shondra; Zhou, Xin; Orr, Brent; Robinson, Giles; Wu, Gang; Korbel, Jan; Peng, Jamy; Pfister, Stefan; Northcott, Paul 分享 收藏
PHASE 2 STUDY OF ALISERTIB IN COMBINATION THERAPY FOR NEWLY DIAGNOSED ATYPICAL TERATOID/RHABDOID TUMOR (AT/RT)- RESULTS FROM SJATRT STRATA B AND C II期研究：阿利sertib联合疗法治疗新诊断的畸胎样/横纹肌样瘤(AT/RT)-SJATRT研究B组和C组结果 Bagchi, Aditi; Upadhyaya, Santhosh A.; Dhanda, Sandeep; Billups, Catherine; Baxter, Patricia; Bendel, Anne; Aguillera, Dolly; Kilburn, Lindsey; Crawford, John; Partap, Sonia; Hanzlik, Emily; Tran, Quynh; Breuer, Alex; Qi, Wenjie; Lu, Congyu; Singh, Anjali; Richardson, Miya; Soans, Eroica; Klimo, Paul; Zhou, Xin; Thomas, Arzu O.; Orr, Brent; Merchant, Thomas; Robinson, Giles W.; Gajjar, Amar 分享 收藏
An integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival 对三项髓母细胞瘤临床试验的综合分析，优化了降低毒性和改善生存的风险分层方法 Smith, Kyle S.; Dhanda, Sandeep K.; Billups, Catherine A.; Sioson, Edgar; Lu, Congyu; Peraza, Airen Zaldivar; Gangwani, Karishma; Li, Yimei; Li, Qian; Lin, Tong; Michalski, Jeff M.; Packer, Roger J.; Olson, James M.; Leary, Sarah E. S.; Fouladi, Maryam; Gajjar, Amar; Zhou, Xin; Onar-Thomas, Arzu; Northcott, Paul A.; Robinson, Giles W. 分享 收藏
Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial 增强髓母细胞瘤分类：整合SJMB12临床试验的IHC和DNA甲基化数据 Dhanda, Sandeep Kumar; Breuer, Alexander; Tran, Quynh T.; Smith, Kyle; Strother, Douglas; Fisher, Michael; Bendel, Anne; Hwang, Eugene; Zhao, Sibo; Gottardo, Nick; Hassall, Timothy; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; McCowage, Geoff; Sullivan, Michale; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery; Onar-Thomas, Arzu; Ellison, David; Northcott, Paul A.; Gajjar, Amar; Robinson, Giles W.; Orr, Brent A. 分享 收藏
AN ONCOGENIC PHOTORECEPTOR PROGRAM UNIFIES DISTINCT CENTRAL NERVOUS SYSTEM TUMORS 一个致癌的光感受器程序统一了不同类型的中央神经系统肿瘤 Gudenas, Brian; Ahmad, Shiekh; Englinger, Bernhard; Liu, Anthony; Zhao, Miao; Paul, Leena; Hadley, Jennifer; Lin, Hong; Li, Yiran; Batts, Melissa; Mittal, Priya; Wu, Stephanie; Lewis, Sara; Han, Katie; Soliman, Taha; Janke, Laure; Meredith, David; Pfaff, Elke; Gojo, Johannes; Cotter, Jennifer; Klimo, Paul; Boop, Frederick; Gajjar, Amar; Robinson, Giles; Rosen, Gabriela; Alexandrescu, Sanda; Jones, David; Orr, Brent; Swartling, Fredrik; Filbin, Mariella; Northcott, Paul 分享 收藏
Molecular insights into response and resistance in children with relapsed/refractory brain tumors on ribociclib combination therapy: results from SJDAWN 关于接受ribociclib联合疗法治疗的复发/难治性脑瘤患儿的应答与耐药性的分子机制研究：SJDAWN研究的结果 Han, Katie; Robinson, Giles W.; Smith, Kyle S.; Kostecka, Anna; Dhanda, Sandeep K.; Lin, Tong; Filipovic, David; Lin, Hong; Mikkelsen, Margit; Sabin, Noah D.; Onar-Thomas, Arzu; Roussel, Martine F.; Stewart, Clinton; Orr, Brent A.; Gajjar, Amar; Northcott, Paul A. 分享 收藏
Robust classification of pediatric brain tumors from cell-free DNA methylomes 基于游离细胞DNA甲基组的儿童脑肿瘤鲁棒性分类 Smith, Kyle; Fischer, Tom; Han, Katie; Kostecka, Anna; Lin, Hong; Senfter, Daniel; Stepien, Natalia; Volz, Stefanie; Schwarz, Nathalie; Wedig, Tatjana; Madlener, Sibylle; Haberler, Christine; Dhanda, Sandeep; Upadhyaya, Santhosh; Schmook, Maria; De Bont, Judith; Haapasalo, Hannu; Dargvainiene, Justina; Leypoldt, Frank; Pfister, Stefan; Hulleman, Esther; Gajjar, Amar; Robinson, Giles; Haapasalo, Joonas; Nordfors, Kristiina; Gojo, Johannes; Maass, Kendra; Pajtler, Kristian; Northcott, Paul 分享 收藏
Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial 局部区域B7-H3 CAR-T细胞治疗复发/难治性中枢神经系统肿瘤：Loc3CAR试验的初步临床经验 Bertrand, Kelsey; Hanzlik, Emily; Chiang, Jason; Pinto, Soniya; Selukar, Subodh; Kosteka, Anna; Smith, Kyle; Han, Katie; Ibanez, Jorge; Tlais, Dana; Orr, Brent; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugmam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Crawford, Jeremy; Robinson, Giles; Park, Julie; Northcott, Paul; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher 分享 收藏
Tumor inflammation-associated neurotoxicities for patients treated with intracranial B7-H3-CAR T cells on a phase I clinical trial I期临床试验中接受颅内B7-H3-CAR T细胞治疗的患者的肿瘤炎症相关神经毒性 Hanzlik, Emily M.; Bertrand, Kelsey C.; Chiang, Jason; Pinto, Soniya; Khan, Raja B.; Solanki, Arun; Selukar, Subodh; Wang, Yu; Bakare, Deborah; Swartz, Kate; Gajjar, Amar; Robinson, Giles W.; Park, Julie R.; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher 分享 收藏
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target ELP1相关Sonic hedgehog型髓母细胞瘤的遗传建模识别MDM2为选择性治疗靶点 Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul 分享 收藏
Nuclear Transport as a Therapeutic Vulnerability in ZFTA-RELA Ependymoma ZFTA-RELA室管膜瘤中核转运作为治疗性易损靶点 Ippagunta, Siri; Arabzade, Amir; Varadharajan, Srinidhi; Emanus, Erik; Bland, Amanda; Kardian, Alisha; Laboe, Nicolas; Sun, Hua; Zheng, Tuyu; Orisme, Wilda; Johnson, Melissa; Rodgers, Britanny; Turner, Gregory; Steinberg, Jeffrey; Freeman, Burgess; Roussel, Martine; Shelat, Anang; Kriwacki, Richard; Merchant, Thomas; Deneen, Benjamin; Miller, Shondra; Kavirayani, Anoop Murthy; Ellison, David; Onar-thomas, Arzu; Robinson, Giles; Mack, Stephen; Bertrand, Kelsey 分享 收藏
Molecular characterization of the SJMB12 clinical trial for children and young adults with newly diagnosed medulloblastoma SJMB12临床试验的分子特征分析：针对新诊断髓母细胞瘤的儿童及青少年患者 Filipovic, David; Smith, Kyle; Dhanda, Sandeep; Strother, Doug; Fisher, Micheal J.; Bendel, Anne; Hwang, Eugene, I; Zhao, Sibo; Gottardo, Nicholas G.; Hassall, Timothy E. G.; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; Mccowage, Geoffrey; Sullivan, Michael; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery C.; Onar-Thomas, Arzu; Gajjar, Amar; Robinson, Giles W.; Northcott, Paul A. 分享 收藏
INTEGRATED MULTI-OMIC PROFILING REVEALS PROTEOMIC HETEROGENEITY AND PATHWAY DYNAMICS IN MEDULLOBLASTOMA 整合多组学分析揭示了髓母细胞瘤中的蛋白质组异质性和通路动态。 Li, Yiran; North, Kelsey; Lin, Hong; Wu, Stephine; Gudenas, Brian; Smith, Kyle; Yuan, Zuo-Fei; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Dhanda, Sandeep; Atkinson, Natasha; Mercer, Kimberly; High, Andy; Wang, Xusheng; Peng, Junmin; Roussel, Martine; Robinson, Giles; Orr, Brent; Northcott, Paul 分享 收藏
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