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DIVERGENT MEDULLOBLASTOMA CHROMATIN STATES DISCLOSE KDM2B AS A SELECTIVE DEPENDENCY 分化型髓母细胞瘤染色质状态揭示KDM2B为选择性依赖 Tao, Ran; Erkek-Ozhan, Serap; Xu, Beisi; Matsui, Yurika; Mittal, Priya; Smith, Kyle; Li, Yiran; Gao, Qingsong; Darrow, Emily; Xu, Ruijie; Djekidel, Nadhir; Bajpai, Richa; Kumar, Rahul; Reilly, Colleen; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Bhanu, Natarajan; Gudenas, Brian; Paul, Leena; Lin, Hong; Lowe, Kim; Kutscher, Lena; Garcia, Benjamin; Pruett-Miller, Shondra; Zhou, Xin; Orr, Brent; Robinson, Giles; Wu, Gang; Korbel, Jan; Peng, Jamy; Pfister, Stefan; Northcott, Paul 分享 收藏
An integrated analysis of three medulloblastoma clinical trials refines risk-stratification approaches for reducing toxicity and improving survival 对三项髓母细胞瘤临床试验的综合分析，优化了降低毒性和改善生存的风险分层方法 Smith, Kyle S.; Dhanda, Sandeep K.; Billups, Catherine A.; Sioson, Edgar; Lu, Congyu; Peraza, Airen Zaldivar; Gangwani, Karishma; Li, Yimei; Li, Qian; Lin, Tong; Michalski, Jeff M.; Packer, Roger J.; Olson, James M.; Leary, Sarah E. S.; Fouladi, Maryam; Gajjar, Amar; Zhou, Xin; Onar-Thomas, Arzu; Northcott, Paul A.; Robinson, Giles W. 分享 收藏
Enhancing Medulloblastoma Classification: Integrating IHC and DNA Methylation Data from the SJMB12 Clinical Trial 增强髓母细胞瘤分类：整合SJMB12临床试验的IHC和DNA甲基化数据 Dhanda, Sandeep Kumar; Breuer, Alexander; Tran, Quynh T.; Smith, Kyle; Strother, Douglas; Fisher, Michael; Bendel, Anne; Hwang, Eugene; Zhao, Sibo; Gottardo, Nick; Hassall, Timothy; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; McCowage, Geoff; Sullivan, Michale; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery; Onar-Thomas, Arzu; Ellison, David; Northcott, Paul A.; Gajjar, Amar; Robinson, Giles W.; Orr, Brent A. 分享 收藏
AN ONCOGENIC PHOTORECEPTOR PROGRAM UNIFIES DISTINCT CENTRAL NERVOUS SYSTEM TUMORS 一个致癌的光感受器程序统一了不同类型的中央神经系统肿瘤 Gudenas, Brian; Ahmad, Shiekh; Englinger, Bernhard; Liu, Anthony; Zhao, Miao; Paul, Leena; Hadley, Jennifer; Lin, Hong; Li, Yiran; Batts, Melissa; Mittal, Priya; Wu, Stephanie; Lewis, Sara; Han, Katie; Soliman, Taha; Janke, Laure; Meredith, David; Pfaff, Elke; Gojo, Johannes; Cotter, Jennifer; Klimo, Paul; Boop, Frederick; Gajjar, Amar; Robinson, Giles; Rosen, Gabriela; Alexandrescu, Sanda; Jones, David; Orr, Brent; Swartling, Fredrik; Filbin, Mariella; Northcott, Paul 分享 收藏
IDENTIFYING NOVEL TUMORIGENIC MECHANISMS UNDERLYING GROUP 3/4 MEDULLOBLASTOMA USING HARMONIZED AND RHOMBIC LIP-ENRICHED CEREBELLAR ATLASES 识别利用协调性和菱形唇富集的小脑图谱揭示的3/4组髓母细胞瘤的新型肿瘤发生机制 Xu, Ruijie; Martin, Vincentius; Soliman, Taha; Bihannic, Laure; Wang, Lei; Haldipur, Parthiv; Smith, Kyle; Li, Yiran; Mittal, Priya; Lin, Hong; Alexandre, Paula; He, Guanyi; Millen, Kathleen; Northcott, Paul 分享 收藏
Molecular insights into response and resistance in children with relapsed/refractory brain tumors on ribociclib combination therapy: results from SJDAWN 关于接受ribociclib联合疗法治疗的复发/难治性脑瘤患儿的应答与耐药性的分子机制研究：SJDAWN研究的结果 Han, Katie; Robinson, Giles W.; Smith, Kyle S.; Kostecka, Anna; Dhanda, Sandeep K.; Lin, Tong; Filipovic, David; Lin, Hong; Mikkelsen, Margit; Sabin, Noah D.; Onar-Thomas, Arzu; Roussel, Martine F.; Stewart, Clinton; Orr, Brent A.; Gajjar, Amar; Northcott, Paul A. 分享 收藏
Robust classification of pediatric brain tumors from cell-free DNA methylomes 基于游离细胞DNA甲基组的儿童脑肿瘤鲁棒性分类 Smith, Kyle; Fischer, Tom; Han, Katie; Kostecka, Anna; Lin, Hong; Senfter, Daniel; Stepien, Natalia; Volz, Stefanie; Schwarz, Nathalie; Wedig, Tatjana; Madlener, Sibylle; Haberler, Christine; Dhanda, Sandeep; Upadhyaya, Santhosh; Schmook, Maria; De Bont, Judith; Haapasalo, Hannu; Dargvainiene, Justina; Leypoldt, Frank; Pfister, Stefan; Hulleman, Esther; Gajjar, Amar; Robinson, Giles; Haapasalo, Joonas; Nordfors, Kristiina; Gojo, Johannes; Maass, Kendra; Pajtler, Kristian; Northcott, Paul 分享 收藏
DISSECTING MYC-DRIVEN EPIGENETIC MECHANISMS THAT PROMOTE GROUP 3 MEDULLOBLASTOMA UTILIZING HUMANIZED IPSC MODELS 利用人源化iPSC模型解析促进3组髓母细胞瘤的MYC驱动的表观遗传机制 Qadeer, Zulekha; Hou, Elise; Siegel, Dara; Westelman, Samantha; Gudenas, Brian; Smith, Kyle; Ismail, Wazim Mohammed; Wang, Linyu; Beytagh, Mary Clare; Phua, Ronald; Hendrikse, Liam; Huang, Miller; Gaspar-Maia, Alexandre; Northcott, Paul; Taylor, Michael; Weiss, William 分享 收藏
CELL-FREE DNA ANALYSIS OF CSF SAMPLES ENABLES ASSESSMENT OF TREATMENT RESPONSE AND TRACKING OF CAR T-CELLS POST-LOCOREGIONAL DELIVERY IN PEDIATRIC BRAIN TUMOR PATIENTS 脑脊液样本的无细胞DNA分析能够评估治疗反应，并追踪在儿科脑肿瘤患者中局部区域给药后的CAR T细胞。 Kostecka, Anna; Smith, Kyle S.; Han, Katie; Martin, Vincentius; Lin, Hong; Langfitt, Deanna; Ward, Meghan B.; Walhart, Tara; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher; Bertrand, Kelsey C.; Northcott, Paul A. 分享 收藏
Locoregional B7-H3 CAR-T cells for relapsed/refractory CNS tumors: preliminary clinical experience of the Loc3CAR trial 局部区域B7-H3 CAR-T细胞治疗复发/难治性中枢神经系统肿瘤：Loc3CAR试验的初步临床经验 Bertrand, Kelsey; Hanzlik, Emily; Chiang, Jason; Pinto, Soniya; Selukar, Subodh; Kosteka, Anna; Smith, Kyle; Han, Katie; Ibanez, Jorge; Tlais, Dana; Orr, Brent; Langfitt, Deanna; Metais, Jean-Yves; Lockey, Timothy; Willis, Catherine; Fazio, Frank; Shanmugmam, Raghu; Tian, Liqing; Walhart, Tara; Wang, Yu; Allmon, Patricia; Perry, Scott; Schell, Sarah; Adams, Polly; Ward, Meghan; Meehl, Michaela; Akel, Salem; Poston, Leigh; Bag, Asim; Mack, Stephen; Klimo, Paul; Gajjar, Amar; Thomas, Paul; Crawford, Jeremy; Robinson, Giles; Park, Julie; Northcott, Paul; Gottschalk, Stephen; Krenciute, Giedre; Derenzo, Christopher 分享 收藏
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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target ELP1相关Sonic hedgehog型髓母细胞瘤的遗传建模识别MDM2为选择性治疗靶点 Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul 分享 收藏
Molecular characterization of the SJMB12 clinical trial for children and young adults with newly diagnosed medulloblastoma SJMB12临床试验的分子特征分析：针对新诊断髓母细胞瘤的儿童及青少年患者 Filipovic, David; Smith, Kyle; Dhanda, Sandeep; Strother, Doug; Fisher, Micheal J.; Bendel, Anne; Hwang, Eugene, I; Zhao, Sibo; Gottardo, Nicholas G.; Hassall, Timothy E. G.; Elster, Jennifer; Perreault, Sebastien; Ramaswamy, Vijay; Partap, Sonia; Laughton, Stephen; Cohn, Richard; Chintagumpala, Murali; Mccowage, Geoffrey; Sullivan, Michael; Sayour, Elias; Bowers, Daniel C.; Marks, Asher; Wright, Avery C.; Onar-Thomas, Arzu; Gajjar, Amar; Robinson, Giles W.; Northcott, Paul A. 分享 收藏
INTEGRATED MULTI-OMIC PROFILING REVEALS PROTEOMIC HETEROGENEITY AND PATHWAY DYNAMICS IN MEDULLOBLASTOMA 整合多组学分析揭示了髓母细胞瘤中的蛋白质组异质性和通路动态。 Li, Yiran; North, Kelsey; Lin, Hong; Wu, Stephine; Gudenas, Brian; Smith, Kyle; Yuan, Zuo-Fei; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Dhanda, Sandeep; Atkinson, Natasha; Mercer, Kimberly; High, Andy; Wang, Xusheng; Peng, Junmin; Roussel, Martine; Robinson, Giles; Orr, Brent; Northcott, Paul 分享 收藏
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