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W

William C. Mobley

university of california san diego

84H指数
323论文数
2.4W被引数
收录论文 111
发表时间
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Preformed fibrils of α-synuclein rapidly activate LRRK2 on early endosomes, driving Rab5 phosphorylation and disrupting endolysosomal and synaptic functionα-突触核蛋白预形成的原纤维能快速激活早期内体的LRRK2，驱动Rab5磷酸化并破坏内溶酶体和突触功能
errnpj Parkinson's Disease
IF8.2
err2026-05-12
err0
errOAAI
errXinxin Zuo; Zeyu Chen; Xu-Qiao Chen; Dongxu Guan; Peter X. Shaw; Aaron Johnstone; Ann Becker; Utpal Das; William C. Mobley
err分享
err收藏
Stereology with OPEN-Stereo: low-cost, accessible, and accurate cellular quantification立体学方法与OPEN-Stereo：低成本、易获取且精确的细胞定量分析
errScientific Reports
IF3.9
err2025-12-30
err0
errOAAI
errCassia Overk; William C. Mobley
err分享
err收藏
Harnessing the Neurobiology of Empathy and Compassion to Alleviate Burnout in Neurology利用共情与慈悲的神经生物学机制以减轻神经科的职业倦怠
errAnnals of Neurology
IF7.7
err2025-11-26
err0
errOAAI
errFadel Zeidan PhD; Joseph D. Stern MD; William C. Mobley MD, PhD
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err收藏
Tau pathology differs by sex in Alzheimer's disease in Down syndrome在唐氏综合征中，阿尔茨海默病患者的Tau病理存在性别差异。
errAlzheimer's & Dementia
IF11.1
err2025-10-23
err0
errOAAI
errXu-Qiao Chen; Xinxin Zuo; William C. Mobley
err分享
err收藏
An Anti-β-Amyloid vaccine for treating cognitive deficits in a mouse model of down syndrome (vol 11, e0152471, 2016)一种抗β-淀粉样蛋白疫苗用于治疗唐氏综合征小鼠模型中的认知缺陷（卷 11，e0152471，2016）
errPLOS ONE
IF2.6
err2025-05-12
err0
errOAAI
errBelichenko, Pavel V.; Madani, Rime; Rey-Bellet, Lorianne; Pihlgren, Maria; Becker, Ann; Plassard, Adeline; Vuillermot, Stephanie; Giriens, Valerie; Nosheny, Rachel L.; Kleschevnikov, Alexander M.; Valletta, Janice S.; Bengtsson, Sara K. S.; Linke, Gordon R.; Maloney, Michael T.; Hickman, David T.; Reis, Pedro; Granet, Anne; Mlaki, Dorin; Lopez-Deber, Maria Pilar; Do, Long; Singhal, Nishant; Masliah, Eliezer; Pearn, Matthew L.; Pfeifer, Andrea; Muhs, Andreas; Mobley, William C.
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err收藏
PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)唐氏综合症中Tau蛋白病理的PET成像及其与淀粉样蛋白，纵向MRI和认知变化的关系: 唐氏综合症生物标志物计划 (DSBI) 的结果
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2025-02-06
err76
PREAI
errRafii, Michael S.; Lukic, Ana S.; Andrews, Randolph D.; Brewer, James; Rissman, Robert A.; Strother, Stephen C.; Wernick, Miles N.; Pennington, Craig; Mobley, William C.; Ness, Seth; Matthews, Dawn C.
err分享
err收藏
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society想象，发现，启发: 21三体研究学会第四届国际会议论文集
errNEUROMOLECULAR MEDICINE
IF3.9
err2025-01-05
err0
errOAAI
errFlores-Aguilar, Lisi; Hamlett, Eric D.; Araya, Paula; Barone, Eugenio; Bhattacharyya, Anita; Carmona-Iragui, Maria; Chan, Li; Christian, Brad; Costa, Alberto C. S.; Costanzo, Floriana; Del Hoyo Soriano, Laura; Dierssen, Mara; Eichler, Evan E.; Fisher, Elizabeth; Galbraith, Matthew; Ghosh, Sujay; Gimenez, Sandra; Guedj, Faycal; Guidi, Sandra; Iulita, Maria Florencia; Mobley, William; Pelleri, Maria Chiara; Potier, Marie-Claude; Rabin, Karen R.; Rachubinski, Angela; Rebillat, Anne-Sophie; Rubenstein, Eric; Saternos, Hannah; Sordo, Lorena; Strydom, Andre; Valle-Tamayo, Natalia; Waugh, Katherine A.; Yu, Eugene; Zeldich, Ella; Busciglio, Jorge; Head, Elizabeth
err分享
err收藏
Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis (vol 87, pg 963, 2015)
errNEURON
IF15
err2024-12-01
err0
errOAAI
errZhao, Yingjun; Tseng, I. -Chu; Heyser, Charles J.; Rockenstein, Edward; Mante, Michael; Adame, Anthony; Zheng, Qiuyang; Huang, Timothy; Wang, Xin; Arslan, Pharhad E.; Chakrabarty, Paramita; Wu, Chengbiao; Bu, Guojun; Mobley, William C.; Zhang, Yun-wu; St George-Hyslop, Peter; Masliah, Eliezer; Fraser, Paul; Xu, Huaxi
err分享
err收藏
The Role of Biomedical and Pharmaceutical Sciences in Pharmacy Education and Practice
errAMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
IF3.5
err2024-12-01
err0
errOAAI
errMobley, W. Cary; Harrold, Marc W.; Hall, Julianne M.; Oliveira, Marcos A.; Bloom, Timothy J.
err分享
err收藏
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
errELIFE
IF0
err2024-07-19
err1
errOAAI
errZoltowska, Katarzyna Marta; Das, Utpal; Lismont, Sam; Enzlein, Thomas; Maesako, Masato; Houser, Mei C. Q.; Franco, Maria Luisa; Ozcan, Burcu; Moreira, Diana Gomes; Karachentsev, Dmitry; Becker, Ann; Hopf, Carsten; Vilar, Marcal; Berezovska, Oksana; Mobley, William; Chavez-Gutierrez, Lucia
err分享
err收藏
BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-06-01
err2
errOAAI
errGu, Yingli; Pope, Alexander; Smith, Charlene; Carmona, Christopher; Johnstone, Aaron; Shi, Linda; Chen, Xuqiao; Santos, Sarai; Bacon-Brenes, Claire Cecile; Shoff, Thomas; Kleczko, Korbin M.; Frydman, Judith; Thompson, Leslie M.; Mobley, William C.; Wu, Chengbiao
err分享
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γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome
errANNALS OF NEUROLOGY
IF7.7
err2024-05-15
err3
errOAAI
errChen, Xu-Qiao; Becker, Ann; Albay, Ricardo; Nguyen, Phuong D.; Karachentsev, Dmitry; Roberts, Amanda J.; Rynearson, Kevin D.; Tanzi, Rudolph E.; Mobley, William C.
err分享
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Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration
errNATURE AGING
IF19.4
err2024-03-01
err3
PREAI
errde Luzy, Isabelle R.; Lee, Michael K.; Mobley, William C.; Studer, Lorenz
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err收藏
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer's disease
errMOLECULAR BRAIN
IF2.9
err2023-11-03
err0
errOAAI
errValdes, Phoebe; Henry, Kenneth W.; Fitzgerald, Michael Q.; Muralidharan, Koushik; Caldwell, Andrew B.; Ramachandran, Srinivasan; Goldstein, Lawrence S. B.; Mobley, William C.; Galasko, Douglas R.; Subramaniam, Shankar
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Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain
errANNUAL REVIEW OF NEUROSCIENCE
IF13.2
err2023-07-10
err6
errOAAI
errFu, Xiang-Dong; Mobley, William C.
err分享
err收藏
Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2023-06-28
err2
errOAAI
errOverk, Cassia; Fiorini, Emma; Babolin, Chiara; Vukicevic, Marija; Morici, Catherine; Madani, Rime; Eligert, Valerie; Kosco-Vilbois, Marie; Roberts, Amanda; Becker, Ann; Pfeifer, Andrea; Mobley, William C.
err分享
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Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator
errANNALS OF NEUROLOGY
IF7.7
err2023-04-29
err4
PREAI
errChen, Xu-Qiao; Sawa, Mariko; Becker, Ann; Karachentsev, Dmitry; Zuo, Xinxin; Rynearson, Kevin D.; Tanzi, Rudolph E.; Mobley, William C.
err分享
err收藏
Editorial: Current advances in the study of Down Syndrome: From development to aging社论: 唐氏综合症研究的最新进展: 从发展到衰老
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2023-03-20
err1
errOAAI
errJohnstone, Aaron; Mobley, William
err分享
err收藏
CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons
errNATURE COMMUNICATIONS
IF15.7
err2023-02-08
err17
errOAAI
errWu, Gong-Her; Smith-Geater, Charlene; Galaz-Montoya, Jesus G.; Gu, Yingli; Gupte, Sanket R. R.; Aviner, Ranen; Mitchell, Patrick G. G.; Hsu, Joy; Miramontes, Ricardo; Wang, Keona Q. Q.; Geller, Nicolette R. R.; Hou, Cathy; Danita, Cristina; Joubert, Lydia-Marie; Schmid, Michael F. F.; Yeung, Serena; Frydman, Judith; Mobley, William; Wu, Chengbiao; Thompson, Leslie M. M.; Chiu, Wah
err分享
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Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose
errALZHEIMERS & DEMENTIA
IF11.1
err2022-11-12
err9
errOAAI
errChen, Xu-Qiao; Zuo, Xinxin; Becker, Ann; Head, Elizabeth; Mobley, William C.
err分享
err收藏

研究方向

暂无研究方向
合作学者
合作期刊
K
Karl Friston
H 指数: 260 · 论文数: 2.0K
F
Fred H. Gage
H 指数: 219 · 论文数: 1.1K
I
Irving L. Weissman
H 指数: 215 · 论文数: 1.3K
D
David M. Holtzman
H 指数: 204 · 论文数: 1.0K
E
Eliezer Masliah
H 指数: 195 · 论文数: 1.2K
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